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Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders

Arumugham, Vinu


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{
  "description": "<p>SARS-CoV-2 mRNA vaccines and a viral vector based vaccine have been authorized for use in the US.<br>\nAstraZeneca&rsquo;s viral vector based vaccines have been authorized for use in many European countries.<br>\nNumerous cases of bleeding disorders have been reported following SARS-CoV-2 vaccine<br>\nadministration. Vaccine Adverse Event Reporting System (VAERS) in the US shows 200 cases of<br>\nplatelet disorders following the vaccines. Such cases have also been investigated in Europe following<br>\nAstraZeneca vaccine administration. Prof. P&aring;l Andre Holme of the Oslo University Hospital and Prof.<br>\nAndreas Greinacher at the University of Greifswald have independently found evidence for this being a<br>\nvaccine induced autoimmune disorder. Greinacher and others identified platelet factor 4 (PF4) as the<br>\ntarget of autoantibodies induced by the vaccine. Greinacher&rsquo;s team have named it vaccine-induced<br>\nprothrombotic immune thrombocytopenia (VIPIT).<br>\nAnimal/plant/fungal/viral protein contamination of vaccines and the risk of them inducing autoimmune<br>\ndiseases was predicted and world vaccine regulatory bodies were all repeatedly warned of the dangers.<br>\nSafety engineering processes such as design Failure Modes and Effects Analysis (FMEA) are still being<br>\nignored in the vaccine industry ten years after the Pandemrix induced narcolepsy disaster.<br>\nWe show plant proteins that contaminate the vaccines have high protein sequence homology to epitopes<br>\nknown to be involved in thrombocytopenia, using Immune Epitope Database (IEDB) data and<br>\nBLASTP bioinformatics analysis. BLASTP match score range is 27.8-19.6. The score for the epitope<br>\ninvolved in Pandemrix induced narcolepsy was 19.7, in comparison. The conditions required for<br>\ninducing autoimmunity are immunization using homologous xeneogeneic antigens that are similar to<br>\nself antigens (plant proteins in this case) and costimulation of the innate immune system either by the<br>\nadenovirus, lipid-in-water emulsion or the mRNA in the vaccines acting as adjuvants.<br>\nBleeding disorders are just the latest of numerous vaccine-induced diseases. For every individual<br>\ndiagnosed with VIPIT, thousands will develop subclinical disease. Of course, VIPIT is not the only<br>\nautoimmune disorder induced by these contaminants.<br>\n&nbsp;</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Independent", 
      "@id": "https://orcid.org/0000-0003-1047-1626", 
      "@type": "Person", 
      "name": "Arumugham, Vinu"
    }
  ], 
  "headline": "Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2021-03-27", 
  "url": "https://zenodo.org/record/4641693", 
  "keywords": [
    "Thrombocytopenia", 
    "SARS-CoV-2", 
    "mRNA", 
    "AstraZeneca", 
    "VIPIT", 
    "viral vector", 
    "vaccine", 
    "platelet", 
    "platelet factor 4", 
    "narcolepsy", 
    "Pandemrix", 
    "Immune Epitope DataBase", 
    "adjuvant", 
    "autoimmunity", 
    "xenogeneic antigen", 
    "adenovirus", 
    "lipid", 
    "FMEA"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.4641693", 
  "@id": "https://doi.org/10.5281/zenodo.4641693", 
  "@type": "ScholarlyArticle", 
  "name": "Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders"
}
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