Preprint Open Access

Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders

Arumugham, Vinu


JSON Export

{
  "files": [
    {
      "links": {
        "self": "https://zenodo.org/api/files/4024e139-db10-4cd6-bc7b-e8b8ef95c1ed/platelet.pdf"
      }, 
      "checksum": "md5:7b973fbb38403cc0e35a6de98f54a92b", 
      "bucket": "4024e139-db10-4cd6-bc7b-e8b8ef95c1ed", 
      "key": "platelet.pdf", 
      "type": "pdf", 
      "size": 110629
    }
  ], 
  "owners": [
    37451
  ], 
  "doi": "10.5281/zenodo.4641693", 
  "stats": {
    "version_unique_downloads": 3236.0, 
    "unique_views": 6117.0, 
    "views": 7402.0, 
    "version_views": 7404.0, 
    "unique_downloads": 3236.0, 
    "version_unique_views": 6118.0, 
    "volume": 376138600.0, 
    "version_downloads": 3400.0, 
    "downloads": 3400.0, 
    "version_volume": 376138600.0
  }, 
  "links": {
    "doi": "https://doi.org/10.5281/zenodo.4641693", 
    "conceptdoi": "https://doi.org/10.5281/zenodo.4641692", 
    "bucket": "https://zenodo.org/api/files/4024e139-db10-4cd6-bc7b-e8b8ef95c1ed", 
    "conceptbadge": "https://zenodo.org/badge/doi/10.5281/zenodo.4641692.svg", 
    "html": "https://zenodo.org/record/4641693", 
    "latest_html": "https://zenodo.org/record/4641693", 
    "badge": "https://zenodo.org/badge/doi/10.5281/zenodo.4641693.svg", 
    "latest": "https://zenodo.org/api/records/4641693"
  }, 
  "conceptdoi": "10.5281/zenodo.4641692", 
  "created": "2021-03-27T07:18:40.505020+00:00", 
  "updated": "2021-03-28T00:27:22.325536+00:00", 
  "conceptrecid": "4641692", 
  "revision": 2, 
  "id": 4641693, 
  "metadata": {
    "access_right_category": "success", 
    "doi": "10.5281/zenodo.4641693", 
    "description": "<p>SARS-CoV-2 mRNA vaccines and a viral vector based vaccine have been authorized for use in the US.<br>\nAstraZeneca&rsquo;s viral vector based vaccines have been authorized for use in many European countries.<br>\nNumerous cases of bleeding disorders have been reported following SARS-CoV-2 vaccine<br>\nadministration. Vaccine Adverse Event Reporting System (VAERS) in the US shows 200 cases of<br>\nplatelet disorders following the vaccines. Such cases have also been investigated in Europe following<br>\nAstraZeneca vaccine administration. Prof. P&aring;l Andre Holme of the Oslo University Hospital and Prof.<br>\nAndreas Greinacher at the University of Greifswald have independently found evidence for this being a<br>\nvaccine induced autoimmune disorder. Greinacher and others identified platelet factor 4 (PF4) as the<br>\ntarget of autoantibodies induced by the vaccine. Greinacher&rsquo;s team have named it vaccine-induced<br>\nprothrombotic immune thrombocytopenia (VIPIT).<br>\nAnimal/plant/fungal/viral protein contamination of vaccines and the risk of them inducing autoimmune<br>\ndiseases was predicted and world vaccine regulatory bodies were all repeatedly warned of the dangers.<br>\nSafety engineering processes such as design Failure Modes and Effects Analysis (FMEA) are still being<br>\nignored in the vaccine industry ten years after the Pandemrix induced narcolepsy disaster.<br>\nWe show plant proteins that contaminate the vaccines have high protein sequence homology to epitopes<br>\nknown to be involved in thrombocytopenia, using Immune Epitope Database (IEDB) data and<br>\nBLASTP bioinformatics analysis. BLASTP match score range is 27.8-19.6. The score for the epitope<br>\ninvolved in Pandemrix induced narcolepsy was 19.7, in comparison. The conditions required for<br>\ninducing autoimmunity are immunization using homologous xeneogeneic antigens that are similar to<br>\nself antigens (plant proteins in this case) and costimulation of the innate immune system either by the<br>\nadenovirus, lipid-in-water emulsion or the mRNA in the vaccines acting as adjuvants.<br>\nBleeding disorders are just the latest of numerous vaccine-induced diseases. For every individual<br>\ndiagnosed with VIPIT, thousands will develop subclinical disease. Of course, VIPIT is not the only<br>\nautoimmune disorder induced by these contaminants.<br>\n&nbsp;</p>", 
    "license": {
      "id": "CC-BY-4.0"
    }, 
    "title": "Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "4641692"
          }, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "4641693"
          }
        }
      ]
    }, 
    "keywords": [
      "Thrombocytopenia", 
      "SARS-CoV-2", 
      "mRNA", 
      "AstraZeneca", 
      "VIPIT", 
      "viral vector", 
      "vaccine", 
      "platelet", 
      "platelet factor 4", 
      "narcolepsy", 
      "Pandemrix", 
      "Immune Epitope DataBase", 
      "adjuvant", 
      "autoimmunity", 
      "xenogeneic antigen", 
      "adenovirus", 
      "lipid", 
      "FMEA"
    ], 
    "publication_date": "2021-03-27", 
    "creators": [
      {
        "orcid": "0000-0003-1047-1626", 
        "affiliation": "Independent", 
        "name": "Arumugham, Vinu"
      }
    ], 
    "access_right": "open", 
    "resource_type": {
      "subtype": "preprint", 
      "type": "publication", 
      "title": "Preprint"
    }, 
    "related_identifiers": [
      {
        "scheme": "doi", 
        "identifier": "10.5281/zenodo.4641692", 
        "relation": "isVersionOf"
      }
    ]
  }
}
7,404
3,400
views
downloads
All versions This version
Views 7,4047,402
Downloads 3,4003,400
Data volume 376.1 MB376.1 MB
Unique views 6,1186,117
Unique downloads 3,2363,236

Share

Cite as