Preprint Open Access

Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders

Arumugham, Vinu


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  <identifier identifierType="DOI">10.5281/zenodo.4641693</identifier>
  <creators>
    <creator>
      <creatorName>Arumugham, Vinu</creatorName>
      <givenName>Vinu</givenName>
      <familyName>Arumugham</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-1047-1626</nameIdentifier>
      <affiliation>Independent</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2021</publicationYear>
  <subjects>
    <subject>Thrombocytopenia</subject>
    <subject>SARS-CoV-2</subject>
    <subject>mRNA</subject>
    <subject>AstraZeneca</subject>
    <subject>VIPIT</subject>
    <subject>viral vector</subject>
    <subject>vaccine</subject>
    <subject>platelet</subject>
    <subject>platelet factor 4</subject>
    <subject>narcolepsy</subject>
    <subject>Pandemrix</subject>
    <subject>Immune Epitope DataBase</subject>
    <subject>adjuvant</subject>
    <subject>autoimmunity</subject>
    <subject>xenogeneic antigen</subject>
    <subject>adenovirus</subject>
    <subject>lipid</subject>
    <subject>FMEA</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2021-03-27</date>
  </dates>
  <resourceType resourceTypeGeneral="Preprint"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/4641693</alternateIdentifier>
  </alternateIdentifiers>
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    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.4641692</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;SARS-CoV-2 mRNA vaccines and a viral vector based vaccine have been authorized for use in the US.&lt;br&gt;
AstraZeneca&amp;rsquo;s viral vector based vaccines have been authorized for use in many European countries.&lt;br&gt;
Numerous cases of bleeding disorders have been reported following SARS-CoV-2 vaccine&lt;br&gt;
administration. Vaccine Adverse Event Reporting System (VAERS) in the US shows 200 cases of&lt;br&gt;
platelet disorders following the vaccines. Such cases have also been investigated in Europe following&lt;br&gt;
AstraZeneca vaccine administration. Prof. P&amp;aring;l Andre Holme of the Oslo University Hospital and Prof.&lt;br&gt;
Andreas Greinacher at the University of Greifswald have independently found evidence for this being a&lt;br&gt;
vaccine induced autoimmune disorder. Greinacher and others identified platelet factor 4 (PF4) as the&lt;br&gt;
target of autoantibodies induced by the vaccine. Greinacher&amp;rsquo;s team have named it vaccine-induced&lt;br&gt;
prothrombotic immune thrombocytopenia (VIPIT).&lt;br&gt;
Animal/plant/fungal/viral protein contamination of vaccines and the risk of them inducing autoimmune&lt;br&gt;
diseases was predicted and world vaccine regulatory bodies were all repeatedly warned of the dangers.&lt;br&gt;
Safety engineering processes such as design Failure Modes and Effects Analysis (FMEA) are still being&lt;br&gt;
ignored in the vaccine industry ten years after the Pandemrix induced narcolepsy disaster.&lt;br&gt;
We show plant proteins that contaminate the vaccines have high protein sequence homology to epitopes&lt;br&gt;
known to be involved in thrombocytopenia, using Immune Epitope Database (IEDB) data and&lt;br&gt;
BLASTP bioinformatics analysis. BLASTP match score range is 27.8-19.6. The score for the epitope&lt;br&gt;
involved in Pandemrix induced narcolepsy was 19.7, in comparison. The conditions required for&lt;br&gt;
inducing autoimmunity are immunization using homologous xeneogeneic antigens that are similar to&lt;br&gt;
self antigens (plant proteins in this case) and costimulation of the innate immune system either by the&lt;br&gt;
adenovirus, lipid-in-water emulsion or the mRNA in the vaccines acting as adjuvants.&lt;br&gt;
Bleeding disorders are just the latest of numerous vaccine-induced diseases. For every individual&lt;br&gt;
diagnosed with VIPIT, thousands will develop subclinical disease. Of course, VIPIT is not the only&lt;br&gt;
autoimmune disorder induced by these contaminants.&lt;br&gt;
&amp;nbsp;&lt;/p&gt;</description>
  </descriptions>
</resource>
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