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Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders

Arumugham, Vinu


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        <foaf:name>Arumugham, Vinu</foaf:name>
        <foaf:givenName>Vinu</foaf:givenName>
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    <dct:title>Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders</dct:title>
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    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2021</dct:issued>
    <dcat:keyword>Thrombocytopenia</dcat:keyword>
    <dcat:keyword>SARS-CoV-2</dcat:keyword>
    <dcat:keyword>mRNA</dcat:keyword>
    <dcat:keyword>AstraZeneca</dcat:keyword>
    <dcat:keyword>VIPIT</dcat:keyword>
    <dcat:keyword>viral vector</dcat:keyword>
    <dcat:keyword>vaccine</dcat:keyword>
    <dcat:keyword>platelet</dcat:keyword>
    <dcat:keyword>platelet factor 4</dcat:keyword>
    <dcat:keyword>narcolepsy</dcat:keyword>
    <dcat:keyword>Pandemrix</dcat:keyword>
    <dcat:keyword>Immune Epitope DataBase</dcat:keyword>
    <dcat:keyword>adjuvant</dcat:keyword>
    <dcat:keyword>autoimmunity</dcat:keyword>
    <dcat:keyword>xenogeneic antigen</dcat:keyword>
    <dcat:keyword>adenovirus</dcat:keyword>
    <dcat:keyword>lipid</dcat:keyword>
    <dcat:keyword>FMEA</dcat:keyword>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2021-03-27</dct:issued>
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    <dct:description>&lt;p&gt;SARS-CoV-2 mRNA vaccines and a viral vector based vaccine have been authorized for use in the US.&lt;br&gt; AstraZeneca&amp;rsquo;s viral vector based vaccines have been authorized for use in many European countries.&lt;br&gt; Numerous cases of bleeding disorders have been reported following SARS-CoV-2 vaccine&lt;br&gt; administration. Vaccine Adverse Event Reporting System (VAERS) in the US shows 200 cases of&lt;br&gt; platelet disorders following the vaccines. Such cases have also been investigated in Europe following&lt;br&gt; AstraZeneca vaccine administration. Prof. P&amp;aring;l Andre Holme of the Oslo University Hospital and Prof.&lt;br&gt; Andreas Greinacher at the University of Greifswald have independently found evidence for this being a&lt;br&gt; vaccine induced autoimmune disorder. Greinacher and others identified platelet factor 4 (PF4) as the&lt;br&gt; target of autoantibodies induced by the vaccine. Greinacher&amp;rsquo;s team have named it vaccine-induced&lt;br&gt; prothrombotic immune thrombocytopenia (VIPIT).&lt;br&gt; Animal/plant/fungal/viral protein contamination of vaccines and the risk of them inducing autoimmune&lt;br&gt; diseases was predicted and world vaccine regulatory bodies were all repeatedly warned of the dangers.&lt;br&gt; Safety engineering processes such as design Failure Modes and Effects Analysis (FMEA) are still being&lt;br&gt; ignored in the vaccine industry ten years after the Pandemrix induced narcolepsy disaster.&lt;br&gt; We show plant proteins that contaminate the vaccines have high protein sequence homology to epitopes&lt;br&gt; known to be involved in thrombocytopenia, using Immune Epitope Database (IEDB) data and&lt;br&gt; BLASTP bioinformatics analysis. BLASTP match score range is 27.8-19.6. The score for the epitope&lt;br&gt; involved in Pandemrix induced narcolepsy was 19.7, in comparison. The conditions required for&lt;br&gt; inducing autoimmunity are immunization using homologous xeneogeneic antigens that are similar to&lt;br&gt; self antigens (plant proteins in this case) and costimulation of the innate immune system either by the&lt;br&gt; adenovirus, lipid-in-water emulsion or the mRNA in the vaccines acting as adjuvants.&lt;br&gt; Bleeding disorders are just the latest of numerous vaccine-induced diseases. For every individual&lt;br&gt; diagnosed with VIPIT, thousands will develop subclinical disease. Of course, VIPIT is not the only&lt;br&gt; autoimmune disorder induced by these contaminants.&lt;br&gt; &amp;nbsp;&lt;/p&gt;</dct:description>
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