10.5281/zenodo.4630775
https://zenodo.org/records/4630775
oai:zenodo.org:4630775
José Lifante
José Lifante
Yingli Shen
Yingli Shen
Irene Zabala Gutierrez
Irene Zabala Gutierrez
Irene Rubia Rodriguez
Irene Rubia Rodriguez
Daniel Ortega
Daniel Ortega
Nuria Fernandez
Nuria Fernandez
Sonia Melle
Sonia Melle
Miriam Granado
Miriam Granado
Jorge Rubio Retama
Jorge Rubio Retama
Daniel Jaque
Daniel Jaque
Erving Ximendes
Erving Ximendes
Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations
Zenodo
2021
2021-03-23
eng
10.5281/zenodo.4630774
https://zenodo.org/communities/eu
Creative Commons Attribution 4.0 International
Dataset of the original data presented in the "Reaching Deeper: Absolute In Vivo Thermal Reading of Liver by Combining Superbright Ag2S Nanothermometers and In Silico Simulations" paper published on Advanced Science.
Abstract: Luminescent nano‐thermometry is a fast‐developing technique with great potential for in vivo sensing, diagnosis, and therapy. Unfortunately, it presents serious limitations. The luminescence generated by nanothermometers, from which thermal readout is obtained, is strongly distorted by the attenuation induced by tissues. Such distortions lead to low signal levels and entangle absolute and reliable thermal monitoring of internal organs. Overcoming both limitations requires the use of high‐brightness luminescent nanothermometers and adopting more complex approaches for temperature estimation. In this work, it is demonstrated how superbright Ag2S nanothermometers can provide in vivo, reliable, and absolute thermal reading of the liver during laser‐induced hyperthermia. For that, a new procedure is designed in which thermal readout is obtained from the combination of in vivo transient thermometry measurements and in silico simulations. The synergy between in vivo and in silico measurements has made it possible to assess relevant numbers such as the efficiency of hyperthermia processes, the total heat energy deposited in the liver, and the relative contribution of Ag2S nanoparticles to liver heating. This work provides a new way for absolute thermal sensing of internal organs with potential application not only to hyperthermia processes but also to advanced diagnosis and therapy.
European Commission
10.13039/501100000780
801305
Nanoparticles-based 2D thermal bioimaging technologies