4608373
doi
10.5281/zenodo.4608373
oai:zenodo.org:4608373
user-fhtw
Sinelnikova, Anna
Östlin, Christofer
Grånäs, Oscar
Brodmerke, Maxim N.
Markl, Erik G.
Caleman, Carl
Reproducibility in the unfolding process of protein induced by an external electric field
Mandl, Thomas
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
<p>The dynamics of proteins are crucial for their function. However, commonly used techniques for studying<br>
protein structures are limited in monitoring time-resolved dynamics at high resolution. Combining electric<br>
fields with existing techniques to study gas-phase proteins, such as single particle imaging using freeelectron<br>
lasers and gas-phase small angle X-ray scattering, has the potential to open up a new era in<br>
time-resolved studies of gas-phase protein dynamics. Using molecular dynamics simulations, we identify<br>
well-defined unfolding pathways of a protein, induced by experimentally achievable external electric<br>
fields. Our simulations show that strong electric fields in conjunction with short-pulsed X-ray sources<br>
such as free-electron lasers can be a new path for imaging dynamics of gas-phase proteins at high<br>
spatial and temporal resolution.</p>
Zenodo
2020-12-26
info:eu-repo/semantics/article
4608372
user-fhtw
1615967139.192212
1226145
md5:1adb06511184c03cb36b4b33819f4375
https://zenodo.org/records/4608373/files/Reproducibility in the unfolding process of protein induced by an external electric field.pdf
public
10.5281/zenodo.4608372
isVersionOf
doi