Journal article Open Access

DEVELOPMENT AND VALIDATION OF BIOANALYTICAL UV SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CARVEDILOL AND DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF CARVEDILOL IN BULK DRUG AND FORMULATION

A. L. Ware1,2*, S.S. Pekamwar3

This Bioanalytical UV-spectrophotometric technique is quite simple, accurate, precise, reproducible, and sensitive. This bioanalytical method for determination of carvedilol. This UV-spectrophotometric method has been used for quantification of Carvedilol in tablet formulation also. The validation procedure confirms that this is an appropriate method for their quantification in the plasma and formulation. It is also used in routine quality control of the formulations containing this entire compound. In spectrum Carvedilol showed absorbance maximum at 289 nm. Validation parameters like linearity was found fron 5-30 μg/ml accuracy was found to be 99.68%, precision was found to be within limit of 98% to 102%.For Ruggedness % RSD was also found less than 2 %.

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