Journal article Open Access

Germinoma talámico: reporte de caso

Navarro-Venebra, José Antonio; Rodríguez-Florido, Marco Antonio


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        <foaf:name>Navarro-Venebra, José Antonio</foaf:name>
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            <foaf:name>Anatomía Patológica, UMAE Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. Ciudad de México, México.</foaf:name>
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        <foaf:name>Rodríguez-Florido, Marco Antonio</foaf:name>
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            <foaf:name>Anatomía Patológica, UMAE Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. Ciudad de México, México.</foaf:name>
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    <dct:title>Germinoma talámico: reporte de caso</dct:title>
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    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2021</dct:issued>
    <dcat:keyword>Tumores de células germinales</dcat:keyword>
    <dcat:keyword>ganglios basales</dcat:keyword>
    <dcat:keyword>tálamo</dcat:keyword>
    <dcat:keyword>germinoma</dcat:keyword>
    <dcat:keyword>patología</dcat:keyword>
    <dcat:keyword>Germ cell tumors</dcat:keyword>
    <dcat:keyword>basal ganglia</dcat:keyword>
    <dcat:keyword>thalamus</dcat:keyword>
    <dcat:keyword>pathology</dcat:keyword>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2021-02-02</dct:issued>
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    <dct:description>&lt;p&gt;&lt;strong&gt;RESUMEN&lt;/strong&gt;&lt;/p&gt; &lt;p&gt;Los tumores de c&amp;eacute;lulas germinales del Sistema Nervioso Central son neoplasias intracraneales poco frecuentes. Generalmente afectan a pacientes menores de 20 a&amp;ntilde;os de edad. Los germinomas se desarrollan a lo largo de la l&amp;iacute;nea media, principalmente en la regi&amp;oacute;n de la gl&amp;aacute;ndula pineal y supraselar. Cuando se localizan en el t&amp;aacute;lamo y los ganglios basales, suelen asociarse a hemiatrofia cerebral. Estas neoplasias son sensibles a radiaci&amp;oacute;n y quimioterapia, lo que les confiere un buen pron&amp;oacute;stico, sin embargo cuando se presentan en el t&amp;aacute;lamo o los ganglios basales se han reportado mayores tasas de recurrencia adem&amp;aacute;s de representar un reto diagn&amp;oacute;stico con los estudios de imagen, a diferencia de cuando se presentan en su localizaci&amp;oacute;n habitual.&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt; &lt;p&gt;&lt;strong&gt;ABSTRACT&lt;/strong&gt;&lt;/p&gt; &lt;p&gt;Germ cell tumors of the Central Nervous System are unusual intracranial neoplasms. They generally affect patients under 20 years of age. Germinomas develop along the midline, mainly on the pineal and suprasellar gland region. When located in the thalamus and basal ganglia, they are usually associated with cerebral hemiatrophy. These neoplasms are sensitive to radiation and chemotherapy, which provides a good prognosis, however when they occur in the thalamus or the basal ganglia, higher recurrence rates have been reported, representing a diagnostic challenge with imaging studies, contrasting with cases in the usual location.&lt;/p&gt;</dct:description>
    <dct:description>{"references": ["Khairy S, Khubrani R, Al-Dandan S, Alobaid A. Thalamic germinoma: a challenging diagnosis, case report and literature review. J Surg Case Rep. 2018; 2018(7): rjy154. DOI: 10.1093/jscr/rjy154", "Wang M, Zhou P, Zhang S, Liu X, Lv L, Wang Z, et al. Clinical features, radiologic findings, and treatment of pediatric germ cell tumors involving the basal ganglia and thalamus: a retrospective series of 15 cases at a single center. Childs Nerv Syst. 2018; 34(3): 423-30. DOI: 10.1007/s00381-017-3632-6", "Wei X-H, Shen H-C, Tang S-X, Gao C-H, Ren J-L, Ai L, et al. Radiologic features of primary intracranial ectopic germinomas: case reports and literature review. Medicine (Baltimore). 2016; 95(52): e5543. DOI: 10.1097/MD.0000000000005543", "Akiyama Y, Suzuki H, Mikuni N. Germinoma mimicking tumefactive demyelinating disease in pediatric patients. Pediatr Neurosurg. 2016; 51(3): 149-53. DOI: 10.1159/000439028", "Rana C, Krishnani N, Kumar R. Intracranial germ cell tumors at unusual locations. J Postgrad Med. 2012; 58(4): 286-9. DOI: 10.4103/0022-3859.105449", "Tang J, Ma Z, Luo S, Zhang Y, Jia G, Zhang J. The germinomas arising from the basal ganglia and thalamus. Childs Nerv Syst. 2008; 24(3): 303-6. DOI: 10.1007/s00381-007-0460-0", "Sartori S, Laverda AM, Calderone M, Carollo C, Viscardi E, Faggin R, et al. Germinoma with synchronous involvement of midline and off-midline structures associated with progressive hemiparesis and hemiatrophy in a young adult. Childs Nerv Syst. 2007; 23(11): 1341-5. DOI: 10.1007/s00381-007-0390-x"]}</dct:description>
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