4450400
doi
10.5281/zenodo.4450400
oai:zenodo.org:4450400
A STATISTICAL APPROACH TO THE DEVELOPMENT OF TELMISARTAN TRANSDERMAL DELIVERY SYSTEM
S.C. Atram, Dr. S.D. Pande
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
<p>Transdermal patches of telmisartan with matrix type were prepared by solvent evaporation technique. In this investigation the matrix of HPMC E15: Eudragit RL100 were cast to achieved sustained release of the drug. A 3<sup>2</sup> factorial design was introduced to prepare the patches. The quantities of Hyroxypropyl methyl cellulose E15 (X<sub>1</sub>), IPM (X<sub>2</sub>) were selected as independent variable. The % drug permeated was selected as response variable. The prepared patches possessed satisfactory physicochemical characteristics. invitro permeation study were performed using modified KC diffusion cell. Kinetic data revealed that the drug release followed Korsemeyer-Peppas model and the mechanism of release was found to be non fickian diffusion. The results of the study shows that telmisartan could be administered transdermally through the matrix type TDDS which seemingly free of potentially hazardous skin irritation.</p>
<p><strong>Keywords: </strong><em>Telmisartan</em><em>, statistical approach, Transdermal patches, HPMC, In-vitro and in vivo evaluation. </em></p>
Zenodo
2021-01-19
info:eu-repo/semantics/article
4450399
1611102436.387015
969416
md5:5ca43e3b04af14ce2ecff2156e7ce977
https://zenodo.org/records/4450400/files/410.Sandeep Atram-Paper telmisartan.pdf
public
10.5281/zenodo.4450399
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doi