SOLID DISPERSION: STRATEGY TO ENHANCE SOLUBILITY

Solid dispersion is defined as dispersion of one or more active pharmaceutical ingredient in a carrier at solid state and an efficient technique to improve dissolution of poorly water-soluble drugs to enhance their bioavailability. Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. Solid dispersions of poorly water-soluble drugs with water-soluble carriers have been reduced the incidence of these problems and enhanced dissolution. The focus of this review article on advantages, disadvantages, types and the method of preparation and characterization of the solid dispersion and various types of marketed preparations.