4436559
doi
10.5281/zenodo.4436559
oai:zenodo.org:4436559
user-covid-19
user-covid19-structure-hub
user-eradicatecovid19
BNT162b2 Vaccine: possible codons misreading, errors in protein synthesis and alternative splicing's anomalies
Smith, Kira
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Covid
Covid-19
Vaccine
BNT162b2
Alternative splicing
Misreading
Codons
Codon
Codon bias
Wobble
Translation
Errors
Protein synthesis
Harmful
Long-Term
<p>The <em>BioNTech/Pfizer</em> <strong>BNT162b2</strong> vaccine against <strong>Covid-19</strong> is composed of an <strong>RNA</strong> having <strong>4284 nucleotides</strong>, divided into <strong>6 sections</strong>, which bring the information to create a <strong>factory of S Spike proteins</strong>, the ones <strong>used by Sars-CoV-2 (Covid-19)</strong> to infect the subject. After that, these proteins are directed <strong>outside the cell</strong>, triggering the immune reaction and <strong>antibody</strong> production.<br>
<br>
The problem is the <strong>heavy alteration of the mRNA</strong>: the <strong>U</strong> of <strong>Uracil</strong> is <strong>replaced</strong> with <strong>Ψ</strong> (Psi) to <strong>fool the immune system</strong> and <strong>avoid degradation</strong>, the <strong>letters of all</strong> codon <strong>triplets</strong> are replaced by a <strong>C</strong> or a <strong>G</strong>, to <strong>extremely increase</strong> the <strong>speed of protein production</strong>, replacement of <strong>some amino acids</strong> with <strong>Proline</strong>, the addition of a <strong>not clear sequence (3'-UTR)</strong>, combined with <strong>anomalies of alternative splicing</strong>, which is the possibility of <strong>errors in translation</strong> of the sequence and <strong>protein synthesis</strong>; they are <strong>not produced equal</strong>, but slightly different.<br>
<br>
All this can be the cause of many <strong>inherited diseases</strong> and various types of <strong>tumors</strong>, from appearance to their growth, up to the metastasis formation.<br>
In essence, what will be created is <strong>anything but well defined as protein S Spike</strong>: just a <strong>transcription error</strong>, <strong>wrong production</strong> of amino acids, then proteins, to cause <strong>serious long-term damage</strong> to human health, despite the <strong>DNA is not modified</strong>, being instead in the cell nucleus and <strong>not in the</strong> <strong>cytoplasm</strong>, where the modified mRNA arrives.<br>
<br>
However, in this case, the <strong>correlation between speed of synthesis and protein expression with synthesis errors</strong>, as well as the <strong>mechanism</strong> that could <strong>affect the translation</strong> of the sequence remain <strong>obscure</strong>, as many <strong>trials</strong> are owned by <em><strong>BioNTech/Pfizer</strong></em>.</p>
Zenodo
2021-01-13
info:eu-repo/semantics/preprint
4436558
user-covid-19
user-covid19-structure-hub
user-eradicatecovid19
3.0
1622402109.701408
224572
md5:d76f65807ec7da775d555c42196bcffd
https://zenodo.org/records/4436559/files/BNT162b2_Vaccine.pdf
public
10.5281/zenodo.4436558
isVersionOf
doi