"Experiment-Id","Experiment-Type","Source-Journal","Source-Title","Source-Author","Source-Snippet","Target-Journal-1","Target-Title-1","Author-Target-1","Target-Snippet + 1","Written-From-Same-Author-As-The-Source-Target: + 1","Written-In-Same-Journal-As-The-Source-Target: + 1","Cosine-English-Source-Target: + 1","Rank-From-User-1-Target: + 1","Rank-From-User-2-Target: + 1","Rank-From-User-3-Target: + 1","Target-Journal-2","Target-Title-2","Author-Target-2","Target-Snippet + 2","Written-From-Same-Author-As-The-Source-Target: + 2","Written-In-Same-Journal-As-The-Source-Target: + 2","Cosine-English-Source-Target: + 2","Rank-From-User-1-Target: + 2","Rank-From-User-2-Target: + 2","Rank-From-User-3-Target: + 2","Target-Journal-3","Target-Title-3","Author-Target-3","Target-Snippet + 3","Written-From-Same-Author-As-The-Source-Target: + 3","Written-In-Same-Journal-As-The-Source-Target: + 3","Cosine-English-Source-Target: + 3","Rank-From-User-1-Target: + 3","Rank-From-User-2-Target: + 3","Rank-From-User-3-Target: + 3","Target-Journal-4","Target-Title-4","Author-Target-4","Target-Snippet + 4","Written-From-Same-Author-As-The-Source-Target: + 4","Written-In-Same-Journal-As-The-Source-Target: + 4","Cosine-English-Source-Target: + 4","Rank-From-User-1-Target: + 4","Rank-From-User-2-Target: + 4","Rank-From-User-3-Target: + 4"
"1","SAME_AUTHOR","PLoS ONE","HER Specific TKIs Exert Their Antineoplastic Effects on Breast Cancer Cell Lines through the Involvement of STAT5 and JNK","Tan, Ming","Members of the HER(ErbB) receptor tyrosine kinase family are known to be key modulators of breast cancer cell growth. They act mainly by promoting tumor cell proliferation and by inhibiting apoptosis, and because of their oncogenic role and their physical accessibility on the surface of the tumor cells, they represent important molecular targets for therapeutic intervention [,]. Indeed, several HER-targeting antibodies and small molecule-type inhibitors (TKIs) have been developed, and the HER2-specific antibody trastuzumab has profoundly improved treatment outcome in HER2 overexpressing human breast cancer [].","Gastric Cancer","HER2-positive gastric cancer","Boku, Narikazu","Up to 30 % of breast cancers overexpress human epidermal growth factor receptor 2 (HER2, c-erbB2), and HER2 positivity is associated with significantly worse outcomes than HER2-negative breast cancer []. Trastuzumab, a monoclonal antibody directed against HER2, was one of the first molecular-targeted drugs to be developed and was originally introduced for the treatment of HER2-positive metastatic breast cancer.","false","false","0.43223053","2","2","2","PLoS Comput. Biol","Induction of Wnt-Inducible Signaling Protein-1 Correlates with Invasive Breast Cancer Oncogenesis and Reduced Type 1 Cell-Mediated Cytotoxic Immunity: A Retrospective Study","Shvartsman, Stanislav","The discovery of molecular targeted therapies revolutionized the treatment of breast cancer. Tamoxifen, a small molecule inhibitor of the estrogen receptor, was the first drug to inhibit the growth of breast cancer cells that depend on female sex hormones. More recently, trastuzumab was developed to inhibit the growth of breast cancer cells that overexpress HER2, an oncogenic member of the epidermal growth factor family of receptors .","false","false","0.5363935","2","4","3","PLoS ONE","mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer","Tan, Ming","The ‘HER2-positive’ subtype of breast cancer overexpresses the human epidermal growth factor receptor 2 (HER2). This receptor tyrosine kinase is part of the epidermal growth factor receptor (EGFR) family, further including HER1 (EGFR), HER3 and HER4 []. It is overexpressed in 10–20% of breast tumors, and the related subtype is associated with increased recurrence and mortality rates [, ].The humanized monoclonal antibody trastuzumab targets specifically the extracellular domain of HER2 and is part of the adjuvant treatment of patients with HER2-positive (HER2+) early breast cancer [].","true","true","0.42524165","1","3","1","PLoS ONE","The Significance of Serum HER2 Levels at Diagnosis on Intrinsic Subtype-Specific Outcome of Operable Breast Cancer Patients","Ahmad, Aamir","The Her-2/neu proto-oncogene is located on chromosome 17q21 and encodes a transmembrane glycoprotein. Approximately 15% to 30% of breast cancer tumors show over-expressed human epidermal growth factor receptor 2 (HER2) protein as a result of gene amplification. Overexpression or amplification of HER2 is associated with poor prognosis []. Since trastuzumab, a humanized monoclonal antibody specific for HER2, became available as a treatment for HER2-positive breast cancer, HER2 status has become important in deciding whether to treat with trastuzumab [].","false","true","0.41197374","3","1","4"
"2","DIFFERENT_JOURNAL","PLoS ONE","Do Your School Mates Influence How Long You Game? Evidence from the U.S.","Jiménez-Murcia, Susana","Global sales and popularity of video games have been rising steadily in the recent decade and are expected to continue their growth in the foreseeable future []. Players under the age of 18 account for about one-quarter of the audience of this growing industry and as the games become increasingly realistic, there has been growing concern among parents, the media and the research community about important social and behavioral effects of video gaming on adolescents [,].","PLoS ONE","The Conceptualisation and Measurement of DSM-5 Internet Gaming Disorder: The Development of the IGD-20 Test","Liu, Yijun","Over the last decade, there has been growing worldwide concern from researchers about ‘gaming addiction’. Official bodies such as the American Psychiatric Association  and numerous scholars – have suggested the need for unification and consensus for the assessment of gaming addiction if this phenomenon is to be considered as an independent clinical entity in the future. Despite the proliferation of research on gaming behaviour over the last few years , , the field has been hindered by the use of inconsistent and non-standardised criteria to assess and identify problematic and/or addictive video game use .","false","true","0.39939693","1","1","3","PLoS ONE","I Am Right, You Are Wrong: How Biased Assimilation Increases the Perceived Gap between Believers and Skeptics of Violent Video Game Effects","McCormick, Cheryl","The question of whether playing violent video games causes aggression has received considerable attention in scientific and public debate. This is not surprising insofar as video game play has become an integral part of the lives of many people. In the United States, 91% of children between the age of two and seventeen play video games . Another survey found that about 97% of American teens play video games .","false","true","0.35606417","4","2","4","PLoS ONE","The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration: CCR7 Homo- and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7","Wu, Yuntao","The human immunodeficiency virus type 1 (HIV-1) infects cells by utilizing its major envelope protein gp120 that binds to CD4 and also to chemokine receptors on human cells. In the case of CD4+ T cells, the HIV gp120 first binds to CD4 and then to CXCR4, which triggers fusion of viral and cellular membranes and confers virus entry to cells. The gp120/CD4/CXCR4 interaction also initiates various intracellular signaling pathways [–], which affect the migration patterns and activation status of target cells.","false","true","0.0","1","3","1","PLoS ONE","The Effect of Online Violent Video Games on Levels of Aggression","McCormick, Cheryl","The video game industry is now the largest entertainment industry in the UK. 2011 industry figures have identified that game sales, including platform and digital, have exceeded both music and video sales . Violent video games have previously been identified to be the most popular video games played by consumers . Research into the effect of violent video games on levels of aggression has led to concerns that they may pose a public health risk .","false","true","0.48435947","2","3","2"
"3","SAME_AUTHOR","PLoS ONE","Differential Adverse Event Profiles Associated with BCG as a Preventive Tuberculosis Vaccine or Therapeutic Bladder Cancer Vaccine Identified by Comparative Ontology-Based VAERS and Literature Meta-Analysis","Tyagi, Anil Kumar","Bacillus Calmette–Guérin (BCG), a live attenuated strain of Mycobacterium bovis, has been the only officially registered human vaccine against tuberculosis (TB) for almost a century [, ]. TB is a serious infectious disease induced by Gram-positive bacterium M. tuberculosis that is estimated to cause more than 2 million human deaths each year. In 2014, there were 9.6 million new cases of TB reported globally, with 5.","J Health Popul Nutr","Rates and Predictors of Consistent Condom-use by People Living with HIV/AIDS on Antiretroviral Treatment in Uganda","Ayiga, Natal","HIV/AIDS continues to be a major global health problem. In 2009, 33.3 million people were living with HIV globally. There were 2.6 million new infections and 1.8 million deaths. Sub-Saharan Africa, with 22.5 million cases, including 1.8 million new infections and 1.3 million deaths, is the most affected region in the world (). Sub-Saharan Africa also witnessed the highest increase in the number of PHAs on ART from a few thousands in 2003 to more than 3 million by the end of 2008.","false","false","0.29535922","4","2","4","PLoS ONE","Abrupt Decline in Tuberculosis among Foreign-Born Persons in the United States","Chaturvedi, Vishnu","Tuberculosis (TB) remains an enormous public health challenge globally, with 9.6 million new cases and 1.5 million deaths each year []. Meanwhile, the United States has experienced a steady decline in TB cases over the past 2 decades, with a record low number of TB cases in 2014 []. This decline has predominately been among U.S.-born persons; the number of cases among foreign-born persons has remained relatively constant, and the TB case rate among the foreign-born population was 13.","false","true","0.39599246","2","3","1","PLoS ONE","A Dual TLR Agonist Adjuvant Enhances the Immunogenicity and Protective Efficacy of the Tuberculosis Vaccine Antigen ID93","Tyagi, Anil Kumar","Approximately two billion people are infected with Mycobacterium tuberculosis (M.tb.) the causative agent of tuberculosis (TB). In 2011 there were over 8 million cases of active TB leading to 1.5 million deaths worldwide. The only vaccine against TB, BCG limits childhood disease, but is variably effective against pulmonary TB in adults, with efficacy estimates ranging from 0 to 80% . Thus there is a pressing need for new vaccine candidates against this devastating disease.","true","true","0.50709254","3","2","3","PLoS ONE","Monosodium Urate Crystals Promote Innate Anti-Mycobacterial Immunity and Improve BCG Efficacy as a Vaccine against Tuberculosis","Scriba, Thomas Jens","The most recent report from WHO estimates 8.8 million new incident Tuberculosis (TB) cases worldwide and 1.3 million deaths [], making TB one of the most deadly human infectious disease. The only currently licensed vaccine for TB is the Bacille Calmette-Guerin (BCG), an attenuated strain of M. bovis, which confers acceptable efficacy against disseminated forms of childhood TB, but highly variable and largely inadequate protection against the much more prevalent adult pulmonary TB [].","false","true","0.5602787","2","4","2"
"4","DIFFERENT_JOURNAL","PLoS ONE","Immune Checkpoint Blockade to Improve Tumor Infiltrating Lymphocytes for Adoptive Cell Therapy","Chan, Daniel","Infiltration of T cells into tumors has been correlated with improved survival in cancer patients. Although T cells are able to adequately infiltrate tumors, they are ineffective at eradicating patients’ tumors. Studies have shown that T cell infiltration in to tumor tissues are associated with reduction in the tumor burden and improved clinical prognosis [,]. Over the last decade, adoptive transfer of tumor infiltrating lymphocytes (TIL) has emerged as a promising approach to induce effective anti-tumor immunity and tumor regression in various cancers [,].","PLoS ONE","A Multifunctional Drug Combination Shows Highly Potent Therapeutic Efficacy against Human Cancer Xenografts in Athymic Mice","Anto, Ruby John","Cancer is a complex disease involving the changes of tumor cells and the tumor microenvironment . As reported, the tumor microenvironment changes in association with tumor development and promotes tumor growth and metastasis , . Uses of drugs that target the tumor microenvironment provide a promising strategy for cancer therapy –. The combination of drugs that target the tumor microenvironment has been proved to be effective in cancer treatment –.","false","true","0.5661191","1","2","3","PLoS ONE","Development of a T Cell Receptor Targeting an HLA-A*0201 Restricted Epitope from the Cancer-Testis Antigen SSX2 for Adoptive Immunotherapy of Cancer","Gangopadhyay, Nupur","Recent advances in the fields of tumor immunology, cancer genomics and gene transfer technologies have permitted the development of therapies based on adoptive transfer of autologous tumor-reactive T cells for the treatment of human malignancies , . Tumor-reactive T cells can be natural, as in the case of tumor infiltrating lymphocytes (TIL) purified from resected lesions and stimulated ex vivo, or generated from peripheral blood by introduction of genes encoding for immune receptors .","false","true","0.5392739","3","1","2","PLoS ONE","Supra-Epiglottic Upper Airway Volume in Elderly Patients with Obstructive Sleep Apnea Hypopnea Syndrome","Wang, Yue","Obstructive sleep apnea syndrome (OSAS) is a type of sleep-disordered breathing characterized by repetitive complete or partial upper airway obstruction during sleep []. This common disorder is especially prevalent, occurring in approximately 24% of middle-aged and elderly adults [, ]. OSAS has been associated with nighttime hypertension [], reduced renal function [], cognitive impairment [], and nocturia in the elderly [, ].","false","true","0.044086672","3","3","2","PLoS ONE","A Novel and Effective Cancer Immunotherapy Mouse Model Using Antigen-Specific B Cells Selected In Vitro","Akatsuka, Yoshiki","Immunotherapy has recently become more widely accepted as an effective means to treat cancer patients. The main player in cell-mediated cancer immunotherapy has been cytotoxic T lymphocytes (CTLs) directed against tumor cells, which recognize via their T-cell receptor (TCR) a particular peptide derived from a tumor antigen (Ag) presented by MHC I on the tumor cells. Such T cells from excised tumor tissues or patients’ blood are selectively expanded in vitro on syngeneic Ag presenting cells (APCs) expressing the tumor Ag with cytokines like IL-2 and then transferred back into the patients , .","false","true","0.5772332","3","4","3"
"5","DIFFERENT_JOURNAL","PLoS Comput. Biol","Strain Mediated Adaptation Is Key for Myosin Mechanochemistry: Discovering General Rules for Motor Activity","Wei, Guanghong","Motors belonging to myosin superfamily are associated with a host of important cellular functions, including muscle contraction, cytokinesis, chemotaxis, targeted vesicle and organelle transport [,,,]. These motors perform mechanical work by producing movement on the actin filament powered by ATP hydrolysis [,,]. While in some cases the myosin motors perform a single cycle of ATP dependent force generation and releases from the actin filament, there are examples where myosin motors perform multiple cycles of stepping on actin prior to its detachment [,].","PLoS ONE","Tension Recovery following Ramp-Shaped Release in High-Ca and Low-Ca Rigor Muscle Fibers: Evidence for the Dynamic State of AMADP Myosin Heads in the Absence of ATP","Csernoch, Laszlo","Muscle contraction results from relative sliding between actin and myosin filaments, coupled with ATP hydrolysis [,], which in turn is produced by attachment-detachment cycle between the myosin head extending from myosin filaments and the sites on actin filaments. On the basis of actomyosin ATPase reaction steps in solution [], myosin head (M), in the form of M • ADP • Pi first attaches to actin (A), and performs a power stroke, associated with reaction, AMADPPi withtin (A), and so that at the end of power stroke, M takes the form AM, i.","false","false","0.45110658","4","3","4","PLoS Comput. Biol","Including Thermal Fluctuations in Actomyosin Stable States Increases the Predicted Force per Motor and Macroscopic Efficiency in Muscle Modelling","McCulloch, Andrew D.","Intracellular forces and motions are generated by cyclic interactions between myosin and actin filaments. Myosin–actin interactions govern many important phenomena, such as molecular transport and muscle contraction. In the currently accepted theory, the globular portion of myosin firmly attaches to the actin filament until an ATP molecule, which fuels the molecular motors, binds to the myosin catalytic domain, releasing the myosin from the actin.","false","true","0.50913316","2","2","3","PLoS ONE","MiR-199a Regulates Cell Proliferation and Survival by Targeting FZD7","Guan, Xin-Yuan","Hepatocellular carcinoma (HCC), the most common primary liver cancer , is one of the most prevalent malignant diseases and the second-most frequent cause of cancer deaths worldwide . Half of the new liver cancer cases and liver cancer deaths worldwide were estimated to occur in China . The dismal prognosis of advanced HCC is largely caused by late detection of the tumors and its high rate of recurrence and metastasis , , .","false","false","0.023333237","3","1","3","PLoS ONE","Definite Differences between  In Vitro Actin-Myosin Sliding and Muscle Contraction as Revealed Using Antibodies to Myosin Head","Kellermayer, Miklos S.","Although more than 50 years have passed since the monumental discovery that muscle contraction results from relative sliding between actin and myosin filaments coupled with ATP hydrolysis , , molecular mechanisms of the myofilament sliding are not yet fully understood. It is generally believed that a myosin head extending from myosin filaments first attaches to actin filaments, undergoes conformational changes to produce unitary myofilament sliding, and then detaches from actin filaments , .","false","false","0.41306788","1","1","4"
"6","SAME_AUTHOR","PLoS ONE","Recombination-Mediated Telomere Maintenance in  Saccharomyces cerevisiae Is Not Dependent on the Shu Complex","Lustig, Arthur J.","Telomeres are nucleoprotein structures at the ends of linear chromosomes that help a cell distinguish a natural chromosome end from a DNA double-strand break (DSB) []. In Saccharomyces cerevisiae, the telomeric DNA consists of 300 ± 75 bp of C1–3A/TG1–3 repetitive sequences, with the G-rich strand extending to form a 3′ single-stranded overhang []. The subtelomeric regions also contain middle repetitive X and Y′ elements.","Elife","Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces","Collins, Kathleen","Telomeres, the physical ends of linear chromosomes, are essential for stable maintenance of chromosomes by facilitating chromosome end replication and preventing them from being degraded or fusing with each other (; ). In most eukaryotes, telomeres are comprised of short tandem DNA repeats. Rather than a blunt end, the telomere consists of a 3’ single-stranded overhang called the G-tail that provides the substrate for telomerase to counteract iterative telomere shortening after each round of DNA replication.","false","false","0.46309912","2","4","4","PLoS Genet","Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication","Zhou, Jin-Qiu","Telomeres are specialized nucleoprotein complexes at the ends of linear eukaryotic chromosomes. The DNA component of telomeres typically comprises a double-stranded DNA (dsDNA) region of a tandem repeat and a 3’ protruding single-stranded DNA (ssDNA) region of the G-rich strand [,]. Both the dsDNA and ssDNA regions are covered with sequence-specific binding proteins. Telomeres protect chromosome ends from degradation or fusion [,].","false","false","0.5766968","2","1","3","PLoS ONE","Depleting Components of the THO Complex Causes Increased Telomere Length by Reducing the Expression of the Telomere-Associated Protein Rif1p","Lustig, Arthur J.","Telomeres are the structure at the ends of eukaryotic linear chromosomes , . They are essential for the maintenance of chromosome integrity, and protect natural DNA ends from being recognized as double-strand breaks. In most organisms, the telomeric DNA is composed of short, tandemly repeated sequences with a strand rich in guanine residues (G-strand) running 5′ to 3′ toward the end of the telomere.","true","true","0.6111323","2","2","2","PLoS ONE","Telomere Recombination Preferentially Occurs at Short Telomeres in Telomerase-Null Type II Survivors","Muzi-Falconi, Marco","Telomeres are the physical ends of eukaryotic chromosomes, and consist of telomeric DNA of repetitive sequence and protein complexes. They prevent chromosomal ends from degradation or fusion, and are essential for chromosomal integrity and genome stability in eukaryotes . In budding yeast Saccharomyces cerevisiae, telomeric DNA consists of ∼300±75 bps of TG1–3/C1–3A repeats with a protruding G-rich single-stranded 3′ overhang (G-overhang) , .","false","true","0.66256356","1","3","1"
"7","DIFFERENT_JOURNAL","PLoS ONE","Quantification of Hepatic Vascular and Parenchymal Regeneration in Mice","Ribatti, Domenico","Livers have the remarkable capability to fully regenerate after major loss of parenchyma. Regeneration requires reconstitution of liver parenchyma and vascular structures. Two major cell types involved in the regeneration at a microscopic scale are hepatocytes and liver sinusoidal endothelial cells (LSECs). Proliferation of these cells leads to the increase of liver mass and growth of blood vessels, respectively [].","PLoS ONE","Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells","Schmidt, Edward E","Liver transplantation is presently the only proven treatment for many liver diseases but is not exempt from complications, thus increasing the need for a new approach using exogenous cell transplantation to restore liver functions[]. Experiments on animals have been performed to establish models and methodologies for liver repopulation using cells other than adult hepatocytes, including hepatic cell lines and hematopoietic, cord blood, mesenchymal stem cells, hepatic stem cells [].","false","true","0.4369201","1","4","4","PLoS ONE","Methods for Isolation and Purification of Murine Liver Sinusoidal Endothelial Cells: A Systematic Review","Asakura, Atsushi","Liver sinusoidal endothelial cells (LSEC) are specific to the liver microcirculation. LSEC line the liver capillaries and transport blood from branches of the portal vein and the hepatic artery into the central vein of liver lobules. They provide a porous barrier between blood components and liver parenchymal cells, i.e., hepatocytes. Moreover their endocytic capacities make them effective scavengers for molecules such as albumin, acetylated low-density lipoproteins (Ac-LDL) and antigens in the bloodstream [, ].","false","true","0.44416508","2","1","3","PLoS ONE","MMP-13  In-Vivo Molecular Imaging Reveals Early Expression in Lung Adenocarcinoma","Singh, Shree Ram","Lung cancer is the leading cause of cancer-related death in the US, with a 5-year survival rate less than 20%. Because the poor prognosis of this disease is due in part to its late diagnosis, finding accurate tools for the early detection of lung cancer is of tremendous importance. Although CT screening studies have been effective in reducing lung-cancer mortality in high-risk patients [], clinicians are now faced with the characterization of numerous peripheral lung nodules; more than 90% of which are benign [].","false","true","0.025963081","1","3","2","PLoS ONE","Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy","Schmidt, Edward E","The liver has long been known to have high regenerative activity, and since the 70% partial hepatectomy (PHx) experiment was reported by Higgins and Anderson in 1931 [], many studies have been performed regarding the mechanisms of liver regeneration [–]. However, the role of liver Kupffer cells in liver regeneration after PHx remains to be elucidated.It is known that hepatocyte proliferation in mice starts around 32 h, and peaks around two to three days after PHx, and liver regeneration ends up to 10 days after PHx.","false","true","0.44710183","3","2","1"
"8","DIFFERENT_JOURNAL","PLoS ONE","The Relationship between Metabolically Obese Non-Obese Weight and Stroke: The Korea National Health and Nutrition Examination Survey","Chen, Chi-Ling","Both obesity and metabolic syndrome (MetS) are well known to increase the risks of coronary artery disease (CAD), stroke, and mortality.Regarding the associations of obesity with CAD, stroke, and mortality, a prospective cohort study found that overweight and obese individuals without MetS had an increased risk of cardiovascular events and death compared to normal weight individuals without MetS (hazard ratio [HR]: 1.","PLoS ONE","Interaction between Maternal and Offspring Diet to Impair Vascular Function and Oxidative Balance in High Fat Fed Male Mice","Aguila, Marcia B.","Over weight and obesity are associated with an increased risk of cardiovascular and metabolic disease, affecting all ages and socioeconomic groups . The prevalence of childhood obesity has increased dramatically in recent decades. Overweight children prematurely develop vascular endothelial dysfunction, hypertension and type 2 diabetes normally found in older obese adults . An increased prevalence of childhood obesity correlates with the increase in the number of overweight and obese women becoming pregnant  and there are now well recognised consequences for the long term health of the children born to pregravid over weight and obese mothers .","false","true","0.43221423","4","2","2","PLoS ONE","Improving Metabolic Health in Obese Male Mice via Diet and Exercise Restores Embryo Development and Fetal Growth","Aguila, Marcia B.","Worldwide obesity is epidemic, with 200 million men and 300 million women over the age of 20 currently classified as obese . While, maternal obesity is well established to adversely affect the oocyte and negatively impact the establishment of pregnancy –, there is now mounting evidence that paternal obesity is also implicated in gamete health and pregnancy outcomes –. An overweight or obese male with a female partner of normal body mass index (BMI), has an increased odds ratio for a longer time to conceive, compared with couples where both are of normal weight , .","false","true","0.31902188","1","1","4","PLoS ONE","Combining α-Radioimmunotherapy and Adoptive T Cell Therapy to Potentiate Tumor Destruction","Shiku, Hiroshi","Radiation therapy is one of the most efficient form of cancer therapy, and is used in the treatment of more than half of all cancer patients [,]. Ionizing radiation is known for its direct cytotoxic action on tumor cells [] as well as the radiation-induced bystander effects which can destroy surrounding malignant cells [–]. Furthermore, impact of local radiotherapy on tumor immunity and immune cell activation has also been documented.","false","true","0.028985508","2","4","1","PLoS ONE","Y1 and Y5 Receptors Are Both Required for the Regulation of Food Intake and Energy Homeostasis in Mice","Luque, Raul M.","A major obstacle in the treatment of overweight and obesity is hunger. Loss of as little as 6–14% of body weight by energy restriction, with or without exercise, in obese men and women significantly increases appetite . This increase in appetite is a significant predictor of subsequent weight regain in humans  and in diet-induced obese rats . Moreover, people carrying obesity-risk genetic polymorphisms consistently show increases in appetite or measured food intake .","false","true","0.34986427","3","3","3"
"9","SAME_AUTHOR","PLoS ONE","Identification of Differentially Expressed microRNAs between the Fenpropathrin Resistant and Susceptible Strains in  Tetranychus cinnabarinus","Zheng, Yun","Not very long ago, the non-coding regions in the genomes of living organisms were considered to be junk DNA. In the last two decades, advances in molecular biology indicated that these regions of genomes can express non-coding RNAs (NcRNAs) which play significant roles in various aspects of cell and organismal biology []. Small RNAs (sRNAs) are less than 200 nucleotides (nt) long non-coding RNA molecules and classified into microRNAs (miRNAs), small nuclear RNAs (snRNAs), small interfering RNAs (siRNAs), piwi-associated RNAs (piRNAs), small nucleolar RNA (snoRNA), and so on [].","PLoS ONE","Identification and Characterization of Long Non-Coding RNAs Related to Mouse Embryonic Brain Development from Available Transcriptomic Data","Calogero, Raffaele A.","Recent transcriptomic researches have revealed that a significant fraction of genome can transcribe non-coding RNAs (ncRNAs), the proportion of which is much larger than previously anticipated , . Over 90% of nucleotides in the human genome can be transcribed, as predicted by the ENCODE project . In the ncRNA world, long non-coding RNAs (lncRNAs) which are manually defined by their size (at least 200 nt) are a distinct group from small RNAs (<200 nt, such as miRNAs and siRNAs).","false","true","0.54726726","3","2","3","PLoS ONE","Genome-Wide Discovery of Long Non-Coding RNAs in Rainbow Trout","Boudinot, Pierre","Global gene expression data in different mammalian species have demonstrated that protein-coding sequences occupy less than 2% of the genome, and the vast majority of the genome is transcribed into non-coding RNAs [–]. These non-coding RNA molecules include small nuclear RNA (snRNA), small nucleolar RNA (snoRNA), microRNA (miRNA), small interfering RNA (siRNA), piwi RNA (piRNA), signal recognition particle (SRP) RNA and lncRNA.","false","true","0.74687904","3","3","4","PLoS ONE","Genome-Wide Identification, Characterization and Evolutionary Analysis of Long Intergenic Noncoding RNAs in Cucumber","Zheng, Yun","The majority of the genome can be transcribed into RNA, but only a small fraction of these transcripts can be translated into proteins [–]. In addition to protein-coding RNA, tRNA, rRNA, and many small noncoding RNAs have been discovered, including miRNA, siRNA and piRNA [, ]. Long intergenic noncoding RNAs (lincRNAs) are a newly described type of noncoding RNA derived from the intergenic regions of the genome [–].","true","true","0.5497","4","1","1","PLoS ONE","Novel Expression Vectors Enabling Induction of Gene Expression by Small-Interfering RNAs and MicroRNAs","Ui-Tei, Kumiko","The discovery of RNA interference  led to the uncovering of a basic cellular regulatory mechanism common to a wide spectrum of organisms. Several families of small RNA were discovered including small interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs) .RNA interference by long double-stranded (ds) RNAs turned out to be driven by small ∼21 nucleotides long RNA molecules derived from the long dsRNA , .","false","true","0.6232418","3","4","2"
"10","SAME_AUTHOR","PLoS ONE","The Functional Response of B Cells to Antigenic Stimulation: A Preliminary Report of Latent Tuberculosis","Wilkinson, Katalin Andrea","Mycobacterium tuberculosis (M.tb) is the causative agent of tuberculosis (TB) disease and is responsible for great annual morbidity and mortality. Furthermore, the World Health Organization (WHO) reported that there were 9.6 million newly reported cases of TB coupled with 1.5 million reported deaths in 2014 []. Although great progress has been made in delineating the disease coupled with the use of an effective chemotherapeutic regimen, TB remains endemic with the growing threat of MDR-TB (multidrug-resistant TB) and XDR-TB (extensively drug-resistant TB) [].","PLoS ONE","Home-Based and Facility-Based Directly Observed Therapy of Tuberculosis Treatment under Programmatic Conditions in Urban Tanzania","Chatterji, Dipankar","In 2014 globally, almost 1.5 million people died from tuberculosis (TB) from an estimated 9.6 million who developed TB []. TB is now the leading cause of death from an infectious disease worldwide, surpassing those caused by Human Immunodefiency Virus []. Globally, TB mortality trends are on the decline [], but remain high despite effective short-course treatment regimens []. In Africa, however, the decline did not meet the 2015 Stop TB Partnership goal of a 50% decline from 1990 to 2015 [].","false","true","0.47681305","2","3","2","PLoS ONE","Rights and Responsibilities of Tuberculosis Patients, and the Global Fund: A Qualitative Study","Caylà, Joan A","Tuberculosis (TB) is still a major setback for public health sector globally, infecting millions of people every year. Alongside human immunodeficiency virus (HIV), TB is the leading reason of death among populations suffering from infectious diseases []. As per World Health Organization (WHO) survey, 9.6 million people developed TB in 2014, out of which 1.5 million died []. Although, TB is a deadly issue for all the regions of the world but it majorly hits communities with low socioeconomic background.","false","true","0.4889499","3","3","1","PLoS ONE","TLR Agonist Augments Prophylactic Potential of Acid Inducible Antigen  Rv3203 against  Mycobacterium tuberculosis H37Rv in Experimental Animals","Izzo, Angelo A.","The pathogen Mycobacterium tuberculosis (M. tuberculosis), the etiologic agent of human tuberculosis (TB), has been estimated to inflict around 9.6 million people (5.4 million men, 3.2 million women and 1.0 million children) world-wide up to the year 2014 [–]. Underlying these statistics is an emerging epidemic of multidrug-resistant tuberculosis (MDR-TB) and extremely drug resistance TB (XDR-TB) [–].","false","true","0.58176804","2","3","3","PLoS ONE","Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study","Wilkinson, Katalin Andrea","The global burden of tuberculosis (TB) is vast, with an estimated 8.6 million new TB cases and 1.3 million deaths due to the disease in 2012 , . Challenges in global TB control include human immunodeficiency virus (HIV)/TB co-infection and lack of effective vaccines and point of care diagnostics . Also, there are no well-validated or specific biomarkers that can predict transition from latent TB to active TB disease or are useful to monitor efficacy of anti-TB drugs , .","true","true","0.5732825","4","3","4"
"11","SAME_JOURNAL","PLoS Negl Trop Dis","Rabies in the Baltic States: Decoding a Process of Control and Elimination","Zinsstag, Jakob","Rabies disease is a fatal mammalian encephalomyelitis caused by the rabies virus of the genus Lyssavirus (family Rhabdoviridae) []. The virus is distributed worldwide, with the exception of the Antarctic, Australia and several islands and although all species of mammals are susceptible to this virus, it infects principally carnivores and bats []. In Europe, the genus lyssavirus evolves through five virus species (four of them circulate in bats only): the classic rabies virus (RABV) affecting non-flying terrestrial mammals only, the european bat lyssaviruses type 1 and type 2 (EBLV-1 and EBLV-2) and the more recently detected Bokelo bat lyssavirus (BBLV) and Lleida bat lyssavirus not yet taxonomically assessed [].","PLoS Negl Trop Dis","Diversity and Epidemiology of Mokola Virus","Rupprecht, Charles E.","The lyssavirus genus consists of twelve species recognized by ICTV  of which five [(Rabies virus (RABV), Lagos bat virus (LBV), Mokola virus (MOKV), Duvenhage virus (DUVV), and Shimoni bat virus (SHIBV)] have been isolated in Africa . LBV, MOKV, DUVV and SHIBV occur exclusively in Africa. SHIBV was recently isolated from Hipposideros vittatus (formerly known as H. commersoni) . Another proposed lyssavirus species is Ikoma lyssavirus (IKOV) isolated from an African civet in Tanzania .","false","true","0.45572415","2","2","3","PLoS ONE","Serological Evidence of Lyssaviruses among Bats on Southwestern Indian Ocean Islands","Roques, Pierre","Lyssaviruses (order: Mononegavirales, family: Rhabdoviridae) are RNA viruses with single-stranded, negative-sense genomes approximately 12 kb in length []. Fifteen distinct viral species, classified into three phylogroups, have been identified to date within the Lyssavirus genus [, ]. These are the prototypic Rabies lyssavirus (RABV) and the 14 genetically related species referred to as rabies-related viruses that cluster into different phylogroups; Duvenhage lyssavirus (DUVV), European bat lyssavirus type 1 (EBLV-1) and type 2 (EBLV-2), Australian bat lyssavirus (ABLV), Irkut lyssavirus (IRKV), Aravan lyssavirus (ARAV), Khujand lyssavirus (KHUV) and Bokeloh bat lyssavirus (BBLV) constitute phylogroup I; Lagos bat lyssavirus (LBV), Mokola lyssavirus (MOKV) and Shimoni bat lyssavirus (SHIV) form phylogroup II; Ikoma lyssavirus (IKOV) and West Caucasian bat lyssavirus (WCBV) make up phylogroup III, whilst the newly described Lleida bat lyssavirus (LLEBV) potentially constituting phylogroup IV [, ].","false","false","0.5186904","2","1","1","PLoS ONE","A Step Forward in Molecular Diagnostics of Lyssaviruses – Results of a Ring Trial among European Laboratories","Markotter, Wanda","Rabies as a notifiable zoonotic disease is an acute, progressive and incurable viral encephalitis which is clinically characterized by central nervous disorders that ultimately lead to death. The disease is caused by different Lyssavirus species of the Rhabdoviridae family , with classical rabies virus (RABV) being responsible for tens of thousands of deaths per year . In Europe, alongside sylvatic rabies in foxes, bat rabies is prevalent in a number of different bat species, mainly caused by the European bat lyssaviruses type 1 and 2 (EBLV-1 and 2) .","false","false","0.53744173","2","2","2","PLoS Negl Trop Dis","Surveillance of Canine Rabies in the Central African Republic: Impact on Human Health and Molecular Epidemiology","Zinsstag, Jakob","Although this fatal disease is preventable since 1884 when Louis Pasteur developed the first vaccine strategy, rabies is still a neglected zoonosis in developing countries where it poses a significant threat to human public health []. More than 55,000 people die of rabies every year mostly in Asia and Africa []. Rabies virus (RABV) belongs to the genus Lyssavirus and family Rhabdoviridae. Although all species of mammals are susceptible to rabies virus infection, only a few species are important as reservoirs of infection [].","true","true","0.43402052","3","2","4"
"12","DIFFERENT_JOURNAL","PLoS ONE","The Functional Human C-Terminome","Helmer-Citterich, Manuela","Minimotifs, also called short linear motifs (SLiMs), are contiguous 2–15 amino acid sequences with a known molecular or cellular function in at least one protein []. The functions of minimotifs include post-translational modifications (PTMs), binding to other proteins and molecules, and protein trafficking. Our laboratory has built one of the initial minimotif search systems, Minimotif Miner [–]. Through working with minimotifs for a decade we have recognized a pattern wherein the carboxylic acid terminus (C-terminus) of many different proteins contains one or more minimotifs.","PLoS ONE","Invertebrate and Vertebrate Class III Myosins Interact with MORN Repeat-Containing Adaptor Proteins","Nam, Sang-Chul","Myosins are a diverse family of actin binding proteins that function as molecular motors. Myosins have an amino-terminal motor domain, a short neck with one or more IQ repeats that serve as calmodulin or light chain binding regions, and a C-terminal tail containing protein-protein interacting motifs [,]. While much is known about the mechanism by which motors transduce chemical energy into movement, the mechanisms controlling cellular localization and regulation of cargo attachment are not well understood [].","false","true","0.30696854","2","3","2","PLoS ONE","Achieving High Accuracy Prediction of Minimotifs","Srinivasan, Narayanaswamy","Minimotifs (also called Short Linear Motifs) are short contiguous peptide pieces of proteins that have a known biological function, which can be categorized into binding, posttranslational modification of the minimotif, and protein trafficking. Minimotifs are involved in nearly all cell processes including intracellular signaling, extra-cellular activities, and disease –.Minimotifs contain both a known biological function and a short protein sequence representation generally of less than 15 amino acids which distinguishes them from protein domains like those in ProSite and other tools such as MEME and SCOP that identify sequence patterns, but do not have known functions , .","false","true","0.6033882","1","1","1","PLoS Genet","Cooperation between Paxillin-like Protein Pxl1 and Glucan Synthase Bgs1 Is Essential for Actomyosin Ring Stability and Septum Formation in Fission Yeast","Gould, Kathleen L","Cytokinesis is the final stage of the eukaryotic cell cycle, when a mother cell separates into two daughter cells. Cytokinesis is mediated by a contractile actomyosin ring (CAR) that is conserved between fungal and animal cells []. In addition to CAR contraction, fungal cells assemble a division septum wall which is essential for cell integrity []. Recent work proposed that the pulling force from CAR contraction is not sufficient to accomplish cytokinesis and that a pushing force is also necessary [], and we showed that support of the lateral cell wall is crucial for proper cytokinesis [].","false","false","0.024213241","3","2","3","PLoS ONE","A Unified Multitask Architecture for Predicting Local Protein Properties","Ouzounis, Christos A.","Proteins participate in every major biological process within every living cell. Therefore, elucidating protein function is a central endeavor of molecular biology. In this work, we focus on predicting local functional properties, which can be summarized as a labeling of amino acids. Many important functional properties can be described in this fashion, including secondary structure, solvent accessibility, transmembrane topology and the locations of signal peptides, DNA-binding residues, protein-binding residues and coiled-coil regions.","false","true","0.28519508","4","4","4"
"13","SAME_JOURNAL","PLoS ONE","Antioxidant Carbocysteine Treatment in Obstructive Sleep Apnea Syndrome: A Randomized Clinical Trial","Taheri, Shahrad","Obstructive sleep apnea syndrome (OSAS) is characterized by repeated episodes of upper airway occlusion during sleep and excessive daytime sleepiness (EDS). It affects at least 4% of adult men and 2% of adult women []. OSAS has been identified as having a causal association with cardiovascular disease []. Continuous positive airway pressure (CPAP) is currently recognized as the first-line treatment for OSAS.","Medicine (Baltimore)","Reversibility of albuminuria and continuous positive airway pressure compliance in patients of obstructive sleep apnea syndrome","Insalaco., Giuseppe","Obstructive sleep apnea syndrome (OSAS) affects approximately 2% to 4% of the population in developed countries[,] and is an independent risk factor for hypertension, stroke, and myocardial infarction.[–] Continuous positive airway pressure (CPAP) treatment has been shown to reduce sleepiness and cardiovascular risk and remains the major therapy for OSAS.[] The goal of CPAP therapy is to reduce the apnea-hypopnea index (AHI) to <5 events per hour during sleep.","false","false","0.49669963","2","4","3","PLoS ONE","Effects of Varying Degrees of Intermittent Hypoxia on Proinflammatory Cytokines and Adipokines in Rats and 3T3-L1 Adipocytes","Zirlik, Andreas","Obstructive sleep apnea (OSA) is a common condition characterized by repeated episodes of upper airway obstruction which result in interruptions of breathing during sleep, recurring episodes of hypoxemia, sleep fragmentation, and daytime sleepiness. OSA affects 3%∼7% of adult men, 2%∼5% of adult women –, and up to 4% of children . OSA is associated with complications in different organ systems, such as cardiovascular morbidities, hypertension, obesity, dyslipidemia, insulin resistance (IR) , , diabetes  and metabolic syndrome , .","false","true","0.6200991","1","2","2","PLoS ONE","Tongue Volume Influences Lowest Oxygen Saturation but Not Apnea-Hypopnea Index in Obstructive Sleep Apnea","Taheri, Shahrad","Obstructive sleep apnea (OSA) is a common condition that is characterized by the collapse of the upper airway during sleep. Its prevalence is reported to be around 5%, and the prevalence of OSA without symptoms is reported to be up to 24%[]. OSA is related to various diseases, such as cardiovascular[], cerebrovascular[], and endocrine diseases[], or cognitive dysfunctions[]. Therefore early diagnosis and treatment of OSA is very important.","true","true","0.45789027","1","4","4","Medicine (Baltimore)","Increased Risk of Parkinson's Disease in Patients With Obstructive Sleep Apnea","Wall., Patrick","Obstructive sleep apnea (OSA) is a sleep disorder characterized by repeated upper airway collapse resulting in apnea/hypopnea and hypoxemia during sleep. Patients with OSA suffered from loud snoring, restless sleep, and excess daytime sleepiness. Approximately 20% of general population are affected by this disorder., OSA is thought to contribute to systemic disease and has been associated with many metabolic, endocrine, and especially cardiovascular diseases.","false","false","0.56195146","1","2","1"
"14","DIFFERENT_JOURNAL","PLoS ONE","Ecosystem Carbon Storage in Alpine Grassland on the Qinghai Plateau","Piao, Shilong","China’s terrestrial ecosystems (both vegetation and soils) have been estimated to have sequestered 20.8–26.8% of the carbon released in industrial CO2 emissions during 1981–2000 []. It is reported that the grasslands of China (331×106 ha) cover only 6–8% of the total world grassland area but contain 9–16% of the world’s total carbon []. To date, a large number of estimates of the forest ecosystem carbon stocks in China have been reported [,], but a comprehensive assessment of carbon storage in China’s grasslands is still lacking [].","PLoS ONE","Seasonal and Inter-Annual Variations in Carbon Dioxide Exchange over an Alpine Grassland in the Eastern Qinghai-Tibetan Plateau","Ding, Aijun","Terrestrial ecosystems play a crucial role in global carbon balance. Grasslands, as an important part of terrestrial ecosystems, comprise 32% of Earth’s natural vegetation []. Estimated relative amounts of carbon storage in different vegetation types indicate that grassland ecosystems store possibly more than 10% of the total carbon in the biosphere []. It can be found that 98% of the carbon store for grassland ecosystems is sequestered below ground [].","false","true","0.4520809","3","3","3","PLoS ONE","Management Impacts on Carbon Dynamics in a Sierra Nevada Mixed Conifer Forest","Hui, Dafeng","Forest ecosystems constitute a major reservoir of global terrestrial carbon [–] and have the potential to sequester anthropogenic carbon emissions. Understanding carbon cycling in forest ecosystems is therefore critical for estimating the global carbon budget. Today most forests have been altered by centuries of human impact. Management practices of timber harvesting, livestock grazing, and fire suppression/exclusion have altered tree density and species composition [].","false","true","0.42027912","3","1","2","Ups. J. Med. Sci","Multidisciplinary treatment of patients with rectal cancer: Development during the past decades and plans for the future","Glimelius, Bengt","Colorectal cancer is the third most common cancer worldwide and the second or third most common cause of cancer death. One-third of the cancers arise in the rectum, the rest in the colon, and virtually all cases are adenocarcinomas. Survival has traditionally been less favourable in rectal than in colon cancer, but this has recently changed. The most likely reasons for the presently slightly better 5-year survival rate in rectal cancer () are the efforts to decrease rectal cancer local recurrence rates by better staging, improved surgery, and incorporation of radiotherapy.","false","false","0.032974623","1","4","1","PLoS ONE","Estimates of Forest Biomass Carbon Storage in Liaoning Province of Northeast China: A Review and Assessment","Liang, Eryuan","From a global perspective forest ecosystems account for 80% of biomass carbon of terrestrial vegetation and play an important role in carbon cycling in terrestrial ecosystems . Forest biomass carbon is significantly affected by timber harvesting, land use, climate change and other natural and human-induced disturbances . Given that forests are the major carbon sink in China, the accurate estimate of forest carbon storage and its change is critical for understanding the budget with respect to China's CO2 emissions, as well as for scientific assessment of the effects of forest management on the capacity of forests to act as carbon sinks.","false","true","0.41734636","2","3","4"
"15","SAME_JOURNAL","PLoS ONE","The Association of Growth Differentiation Factor-15 with Left Ventricular Hypertrophy in Hypertensive Patients","Quintas, Luis Eduardo M.","Hypertensive left ventricular hypertrophy (LVH) is the most common target organ damage, which is preclinical cardiovascular disease. Epidemiological studies show that the prevalence of LVH in hypertensive patients was about 25% to 35% in China , . It has been shown that LVH increases the risk of stroke, coronary heart disease, congestive heart failure, arrhythmias and sudden cardiac death, which is associated with cardiovascular morbidity and mortality, as well as all-cause mortality , .","PLoS ONE","The Effects of 17-Methoxyl-7-Hydroxy-Benzene-Furanchalcone on the Pressure Overload-Induced Progression of Cardiac Hypertrophy to Cardiac Failure","Quintas, Luis Eduardo M.","Hypertension is a continuum that starts with a rise in blood pressure, evolves to left ventricular hypertrophy (LVH), proteinuria or endothelial dysfunction, and, insofar as it is not adequately treated or controlled, finally leads to the development of complications, the most relevant of which are stroke and heart failure . Hypertensive disease is the most frequent background of LVH, and it is generally felt that anti-hypertensive treatment should not only lower blood pressure but also cause the regression of LVH .","true","true","0.42973575","2","2","1","Medicine (Baltimore)","Role of Osteoprotegerin and Its Gene Polymorphisms in the Occurrence of Left Ventricular Hypertrophy in Essential Hypertensive Patients","Mayhan., William","High blood pressure is associated with adverse morphological and functional changes in the cardiovascular system, including left ventricular hypertrophy (LVH), Epidemiological studies show that the prevalence of LVH in Chinese patients with essential hypertension (EH) was about 25% to 35%. LVH is regarded as an independent risk factor for cardiovascular morbidity and mortality.– Many factors, that is, blood pressure level, duration of hypertension, age, obesity, diet, and pharmacologic treatment may influence the occurrence and degree of LVH.","false","false","0.5004346","2","1","4","PLoS ONE","Protective Effect of  Boerhaavia diffusa L. against Mitochondrial Dysfunction in Angiotensin II Induced Hypertrophy in H9c2 Cardiomyoblast Cells","Zazueta, Cecilia","Heart diseases are one of the leading causes of death worldwide . Hypertension accounts a major risk for the development of cardiac diseases through induction of left ventricular hypertrophy and this ultimately leads to congestive heart failure and death . Cardiac hypertrophy is the enlargement of heart with increase in the volume of cardiac cells and prolonged hypertrophic status has been associated with decompensation of heart function, development of heart failure and sudden death in humans .","false","true","0.4568322","2","2","2","Medicine (Baltimore)","Increased mean aliphatic lipid chain length in left ventricular hypertrophy secondary to arterial hypertension","Leischik., Roman","Hypertension is the principal etiology of pathologic left ventricular hypertrophy (LVH).[] Pressure-dependent hemodynamic overload induces left ventricular remodeling as an adaptive response to minimize wall stress. Over time, LVH becomes maladaptive and emerges as a strong and independent risk factor for cardiovascular morbidity (e.g., heart failure, coronary artery disease, cerebrovascular accidents, ventricular arrhythmia) and mortality.","false","false","0.44232586","2","3","3"
"16","SAME_AUTHOR","PLoS Genet","A New Membrane Protein Sbg1 Links the Contractile Ring Apparatus and Septum Synthesis Machinery in Fission Yeast","Gould, Kathleen L","Cytokinesis is the terminal step in the cell cycle during which two cells are formed starting from one. Fungi and metazoans use a plasma membrane anchored actomyosin-based contractile ring to mark the cell division site and contraction of the actomyosin ring generates a part of the tension required to divide the cell [–]. Furthermore, in fungi, actomyosin ring contraction is coordinated with assembly of a carbohydrate rich cell wall / division septum outside of the plasma membrane that provides mechanical strength to the cells [–].","Mol. Biol. Cell","Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis","Li, Rong","Cytokinesis, the last stage of the cell cycle, partitions a mother cell into two daughter cells. Cytokinesis requires coordination of four key events: division-plane selection, contractile-ring assembly, constriction and disassembly of the contractile ring, and plasma membrane fusion and daughter-cell separation (; ; ). The last step involves septum formation in fungi and midbody formation in animal cells.","false","false","0.6111111","1","2","1","PLoS ONE","Mitochondria Localize to the Cleavage Furrow in Mammalian Cytokinesis","Reddy, Hemachandra","Cytokinesis is the final stage of cell division in which one parent cell is physically divided into two daughter cells. In anaphase, astral and spindle microtubules specify the assembly of an actomyosin contractile ring at the equator of the cell between separating chromosomes –. This ensures that daughter cells inherit a proper complement of genetic and cytoplasmic material. As the actomyosin ring contracts, the plasma membrane at the equator of the cell pinches inwards, resulting in a cleavage furrow.","false","false","0.6499337","3","3","2","PLoS Genet","Cooperation between Paxillin-like Protein Pxl1 and Glucan Synthase Bgs1 Is Essential for Actomyosin Ring Stability and Septum Formation in Fission Yeast","Gould, Kathleen L","Cytokinesis is the final stage of the eukaryotic cell cycle, when a mother cell separates into two daughter cells. Cytokinesis is mediated by a contractile actomyosin ring (CAR) that is conserved between fungal and animal cells []. In addition to CAR contraction, fungal cells assemble a division septum wall which is essential for cell integrity []. Recent work proposed that the pulling force from CAR contraction is not sufficient to accomplish cytokinesis and that a pushing force is also necessary [], and we showed that support of the lateral cell wall is crucial for proper cytokinesis [].","true","true","0.56763357","4","1","3","Mol. Biol. Cell","Rap1-dependent pathways coordinate cytokinesis in  Dictyostelium","Parent, Carole","Cell division is a fundamental process that is required for cell pro­liferation and differentiation of cell types. In anaphase, formation of the spindle apparatus pulls the chromosomes toward the poles of the dividing cell and triggers the beginning of cytokinesis, the final step in the separation of a mother cell into two daughter cells. Following the assembly of microtubule filaments in the expanding mitotic spindle, bundles of actin and non–muscle myosin filaments create a contractile ring that constricts the plasma membrane at the furrow region, while actin filaments are formed at the poles of the cells.","false","false","0.5364523","3","4","4"
"17","SAME_JOURNAL","PLoS ONE","Selective Neuromuscular Denervation in Taiwanese Severe SMA Mouse Can Be Reversed by Morpholino Antisense Oligonucleotides","Gillingwater, Thomas H","Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease characterized by α- motor neuron loss in the anterior horn of the spinal cord [] accompanied by muscle atrophy and weakness []. SMA, a leading genetic cause of hereditary infant mortality [], is caused by deletion or mutation of the survival of motor neuron 1 (SMN1) gene []. The copy gene of SMN1, called SMN2, differs at a single nucleotide in exon 7 (C to T), resulting in exon 7 skipping during SMN mRNA transcription [].","PLoS ONE","A Comparative Study of SMN Protein and mRNA in Blood and Fibroblasts in Patients with Spinal Muscular Atrophy and Healthy Controls","Gillingwater, Thomas H","Hereditary proximal spinal muscular atrophy (SMA) is caused by survival motor neuron (SMN) protein deficiency due to homozygous deletion of the SMN1 gene []. A second semi-homologous SMN gene (SMN2) contains a crucial single nucleotide substitution that alters mRNA splicing, resulting in the absence of exon 7 in the large majority of SMN2 mRNA transcripts [, ]. Copy number variation of SMN2 is the most important modifier of disease severity [].","true","true","0.5614858","2","1","4","Mol. Biol. Cell","The E3 ubiquitin ligase mind bomb 1 ubiquitinates and promotes the degradation of survival of motor neuron protein","Tansey, William P.","Spinal muscular atrophy (SMA) is an autosomal recessive neurological disorder characterized by loss of lower motor neurons, leading to weakness and skeletal muscle atrophy, and it is one of the leading genetic causes of infant death. More than 90% of SMA results from deletion of the survival motor neuron (SMN1) gene, with all patients retaining at least one copy of the homologue SMN2 (). While SMN1 produces predominantly full-length SMN protein, SMN2 contains a translationally silent C-to-T transition within exon 7, causing this exon to be mostly skipped during mRNA splicing and producing a truncated protein (SMNΔ7) that is unstable and rapidly degraded (; ; ; ; ).","false","false","0.65777993","3","4","3","PLoS ONE","Plastin 3 Expression Does Not Modify Spinal Muscular Atrophy Severity in the ∆7 SMA Mouse","Pandey, Udai","Proximal Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder and the leading genetic cause of infant mortality [, ]. The disorder is characterized by loss of alpha motor neurons in anterior spinal cord and atrophy of muscle []. SMA is caused by loss of the Survival Motor Neuron 1 gene (SMN1) and retention of SMN2 [, ]. The SMN1 and SMN2 genes essentially differ at a single nucleotide within exon 7 that results in disruption of a splice modulator and the majority of the SMN2 transcript lacking exon 7 [–].","false","true","0.78363913","1","3","1","PLoS Genet","A Motor Function for the DEAD-Box RNA Helicase, Gemin3, in  Drosophila","Cox, Gregory A.","Spinal muscular atrophy (SMA) is an autosomal recessive disorder characterised by degeneration of spinal cord motor neurons, as well as progressive muscular weakness, dysphagia, dyspnoea, and in severe cases, death ,. The majority of SMA patients harbour deletions or mutations in the survival motor neuron (SMN1) gene, which encodes an RNA-binding protein, SMN. In mammalian cells, the SMN protein is stably complexed with a group of proteins including Gemin2 , Gemin3 ,, Gemin4 , Gemin5 , Gemin6 , Gemin7 , and Gemin8 .","false","false","0.46697223","2","2","2"
"18","SAME_JOURNAL","PLoS Genet","Kdm5/Lid Regulates Chromosome Architecture in Meiotic Prophase I Independently of Its Histone Demethylase Activity","Hawley, R. Scott","Meiosis I differs from the second meiotic and mitotic divisions in that homologous chromosomes are segregated, not sister chromatids. Accurate chromosome segregation in meiosis I is preceded by dramatic changes in prophase chromatin organisation. Eventually, homologous chromosomes are mechanically held on the metaphase spindle via chromosome arm cohesion and the crossover-induced physical linkage of chiasmata [].","PLoS Genet","ATM Promotes the Obligate XY Crossover and both Crossover Control and Chromosome Axis Integrity on Autosomes","Hawley, R. Scott","Crossing-over between homologous chromosomes in conjunction with sister chromatid cohesion provides physical connections necessary for accurate chromosome segregation during the first meiotic division . Due to their central role in meiosis, crossovers are tightly controlled in most organisms such that each chromosome pair gets at least one crossover, and multiple crossovers on the same chromosome tend to be evenly and widely spaced ,.","true","true","0.52466065","2","3","2","PLoS ONE","Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase","Wang, Yanchang","Accurate chromosome segregation during mitosis is critical for the maintenance of genome integrity through subsequent generations. The products of DNA replication are held together from S-phase until mitotic entry, when they become visible as individual chromosomes, each constituted of two sister chromatids. Binding of sister chromatids, via kinetochores, to microtubules of the mitotic spindle is required for chromosome segregation.","false","false","0.45769286","3","3","3","Mol. Biol. Cell","akirin is required for diakinesis bivalent structure and synaptonemal complex disassembly at meiotic prophase I","Bloom, Kerry S.","Meiosis is a specialized cell division that leads to the formation of haploid gametes, which in metazoans are the sperm and egg cells. It involves two cellular divisions after one cycle of replication; in the first (MI), homologous chromosomes segregate away from each other, and in the second (MII), sister chromatids separate (). During meiotic prophase I—the period preceding the first meiotic division—chromosomes are organized in the form of bivalents: pairs of homologous chromosomes connected by crossovers and sister chromatid cohesion.","false","false","0.534049","4","3","4","PLoS Genet","Arabidopsis PCH2 Mediates Meiotic Chromosome Remodeling and Maturation of Crossovers","Puchta, Holger","During meiosis genetic crossovers (COs), the products of homologous recombination, in conjunction with sister chromatid cohesion establish physical links, referred to cytologically as chiasmata, between homologous chromosome pairs (homologs) to ensure accurate chromosome segregation at the first nuclear division that follows prophase I. In the absence of crossing over the homologs segregate randomly.","false","true","0.5744563","3","3","1"
"19","DIFFERENT_JOURNAL","PLoS ONE","Neural Activity during Voluntary Movements in Each Body Representation of the Intracortical Microstimulation-Derived Map in the Macaque Motor Cortex","Aumann, Tim D","It is generally accepted that the motor cortex has a topographically organized map of body parts, which is often identified by repetitive intracortical microstimulation (ICMS). During ICMS of the motor cortex, application of a small electrical current evokes involuntary twitches of specific body parts. The topographic body map derived by ICMS has long been thought to reflect the somatotopic organization of motor output from the motor cortex [–] and is used to determine the locations for placing anatomical tracers [–] as well as for inducing lesions [–].","PLoS ONE","Motor Imagery Cognitive Network after Left Ischemic Stroke: Study of the Patients during Mental Rotation Task","Avenanti, Alessio","Motor imagery has been employed in neurological rehabilitation to improve the overall behavior performance after stroke –. During motor imagery, the representation of a specific motor action is implicitly activated within working memory, but without an overt motor output . Posterior parietal cortex, premotor and supplementary motor areas, primary motor cortex, and subcortical basal ganglia were activated during motor imagery –.","false","true","0.41422594","4","1","4","PLoS ONE","Evaluation of EEG Oscillatory Patterns and Cognitive Process during Simple and Compound Limb Motor Imagery","Maurits, Natasha M.","Motor imagery (MI), defined as mental rehearsal of a motor act without any overt motor output, can modify the neuronal activity in the primary sensorimotor areas in a very similar way as motor execution –. In addition, motor imagery has also been demonstrated beneficial in motor rehabilitation in patients with movement disorders, and it plays a significantly important role in clinical and neuroscience studies .","false","true","0.3239864","2","3","4","PLoS ONE","Population-Based Drug Resistance Surveillance of Multidrug-Resistant Tuberculosis in Taiwan, 2007-2014","Sola, Christophe","Tuberculosis (TB) is a major infectious disease worldwide. The World Health Organization (WHO) estimated that there are 9.6 million new TB cases and 1.5 million deaths annually []. In 2014, there were 11,326 new TB cases and 591 deaths were notified in Taiwan. The incidence rate was 48.4 cases per 100,000 populations. The TB incidence increased with age and 52.1% of new TB cases were in the age group of 65 years old or over.","false","true","0.019817527","1","2","4","PLoS ONE","Interaction of Motor Training and Intermittent Theta Burst Stimulation in Modulating Motor Cortical Plasticity: Influence of BDNF Val66Met Polymorphism","Chen, Robert","The neural circuitry in the human motor cortex commands highly sophisticated motor behaviors during goal-directed movements. It has been demonstrated that the motor map representation in the motor cortex is susceptible to changes in motor activity or experience , . After injuries to the motor cortex, rehabilitative training reshapes the motor map reorganization, which is thought to play a role in motor functional recovery .","false","true","0.49827883","3","4","4"
"20","SAME_AUTHOR","PLoS ONE","Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary Fibrosis","Mora, Ana","Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic lung disease of unknown aetiology and increasing incidence []. It is characterised by the pathological deposition of fibrous matrix, particularly collagen, within the lung parenchyma, leading to rapidly decreasing lung function and ultimately respiratory failure. The survival of IPF patients is poor with 5-year survival rates worse than most cancers [] and there are currently limited treatment options available due, in part, to our limited understanding of the mechanisms underlying the disease.","PLoS ONE","Adverse Events of Pirfenidone for the Treatment of Pulmonary Fibrosis: A Meta-Analysis of Randomized Controlled Trials","Baradaran, Hamid Reza","Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease of unknown etiology that is clinically characterized by progressive worsening of dyspnea and lung function, and the 3- and 5-year mortality rates at approximately 50% and 80%, respectively, in the absence of lung transplantation , . To date, the results of pharmacologic trials for treating IPF have been disappointing.","false","true","0.42144194","2","4","1","PLoS ONE","Impact of Comorbidities on Mortality in Patients with Idiopathic Pulmonary Fibrosis","Wu, Min","Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and irreversible lung disease of unknown aetiology []. It is the most common form of idiopathic interstitial lung disease, with a prevalence of 14 to 63 per 100.000 (reviewed in []), mainly diagnosed in the elderly where the prevalence increases dramatically and a predominance in men and ex/current smokers [, ]. The disease is characterised by progressive worsening of lung function, significantly affects health-related quality of life and carries a prognosis that is worse than that of many cancers [].","false","true","0.4681911","2","2","2","PLoS ONE","MMP-13  In-Vivo Molecular Imaging Reveals Early Expression in Lung Adenocarcinoma","Singh, Shree Ram","Lung cancer is the leading cause of cancer-related death in the US, with a 5-year survival rate less than 20%. Because the poor prognosis of this disease is due in part to its late diagnosis, finding accurate tools for the early detection of lung cancer is of tremendous importance. Although CT screening studies have been effective in reducing lung-cancer mortality in high-risk patients [], clinicians are now faced with the characterization of numerous peripheral lung nodules; more than 90% of which are benign [].","false","true","0.3894462","1","3","4","PLoS ONE","Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation","Mora, Ana","Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease often leading to patient death [–]. IPF is the most common fibrotic lung disease with a mean survival of 2 ½ years. Increased collagen type I production and accumulation is the hallmark of IPF [,]. Collagens build the scaffold of the human body and are the major constituent of extracellular matrix (ECM) []. The balance between collagen degradation and production is tightly regulated in normal tissues.","true","true","0.4593727","3","1","3"
"21","SAME_AUTHOR","PLoS ONE","Structural Plasticity and Conformational Transitions of HIV Envelope Glycoprotein gp120","Wu, Yuntao","Human immunodeficiency virus HIV-1 is the etiological agent of acquired immunodeficiency syndrome (AIDS), which infects CD4+ lymphocytes in humans , . The entry of HIV into target cells initiates with the sequential interaction of gp120 subunits of viral envelope glycoprotein (Env) with CD4 glycoprotein receptor and the seven-transmembrane chemokine receptor on the host cell surface , , , . Interaction of gp120 with its cellular receptors causes large conformational changes on gp120 as shown by biophysical, biochemical and crystallographic studies , , .","PLoS Comput. Biol","Analysis of Physicochemical and Structural Properties Determining HIV-1 Coreceptor Usage","Kosakovsky Pond, Sergei L.","The entry of the human immunodeficiency virus (HIV) into human cells is initiated by binding of the viral envelope glycoprotein gp120 to the cellular CD4 receptor , . This primary interaction induces conformational changes in gp120  that enable viral binding to one of the cell-surface coreceptors CCR5 or CXCR4 . The interaction of gp120 with the coreceptor induces a series of further rearrangements in the envelope glycoproteins that trigger fusion of the virus and cell membranes .","false","false","0.61967736","2","3","2","PLoS Pathog","Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation","Rey, Félix A.","HIV/AIDS is a global health epidemic. Over 2 million people die annually from the disease, which is caused by human immunodeficiency virus (HIV) infection. HIV-1 entry into target cells is initiated by the interaction of the surface envelope glycoproteins (Env) with CD4 and a co-receptor (typically CCR5 or CXCR4) on target cells . Env is a heterodimer of a transmembrane glycoprotein (gp41) and a surface glycoprotein (gp120); these dimers are organized as trimers on the surface of the viral membrane.","false","false","0.6115766","1","3","4","PLoS ONE","The HIV-1 Gp120/CXCR4 Axis Promotes CCR7 Ligand-Dependent CD4 T Cell Migration: CCR7 Homo- and CCR7/CXCR4 Hetero-Oligomer Formation as a Possible Mechanism for Up-Regulation of Functional CCR7","Wu, Yuntao","The human immunodeficiency virus type 1 (HIV-1) infects cells by utilizing its major envelope protein gp120 that binds to CD4 and also to chemokine receptors on human cells. In the case of CD4+ T cells, the HIV gp120 first binds to CD4 and then to CXCR4, which triggers fusion of viral and cellular membranes and confers virus entry to cells. The gp120/CD4/CXCR4 interaction also initiates various intracellular signaling pathways [–], which affect the migration patterns and activation status of target cells.","true","true","0.59686685","2","3","3","PLoS ONE","Nef Neutralizes the Ability of Exosomes from CD4+ T Cells to Act as Decoys during HIV-1 Infection","Pöhlmann, Stefan","The Human Immunodeficiency Virus types 1 and 2 (HIV-1 and HIV-2) mainly infect T lymphocytes and macrophages/monocytes that express CD4, a cell surface type I transmembrane glycoprotein that is the primary receptor for HIV. Host cell infection begins with the interaction of the gp120 subunit of the viral envelope glycoprotein (Env) complex with CD4. This interaction leads to conformational changes in gp120 that increase its affinity for a co-receptor, usually CCR5 or CXCR4 chemokine receptors.","false","true","0.7033533","4","3","1"
"22","DIFFERENT_JOURNAL","PLoS ONE","Impact of Multi-Targeted Antiretroviral Treatment on Gut T Cell Depletion and HIV Reservoir Seeding during Acute HIV Infection","Emery, Sean","Three decades after the discovery of antiretroviral therapy (ART), complete eradication of HIV infection has not been achieved except under unique circumstances . A slightly less difficult target may be the long-term, drug-free remission of HIV or functional cure through modulation of immune responses; the basis for therapeutic vaccination approaches that, to date, have not provided evidence of control .","PLoS ONE","Lack of Protection following Passive Transfer of Polyclonal Highly Functional Low-Dose Non-Neutralizing Antibodies","Lu, Shan","While a large number of novel, broadly neutralizing antibodies have been described recently, the induction of such antibodies through vaccination in humans has proven difficult . Neutralizing antibodies develop in approximately one third of infected patients, only after two to three years of infection –. However, the mechanism by which these individuals are able to induce broad humoral immunity, though often after viral escape, is not understood.","false","true","0.2284161","1","2","2","PLoS ONE","Comparison of the Cancer Gene Targeting and Biochemical Selectivities of All Targeted Kinase Inhibitors Approved for Clinical Use","Shellman, Yiqun G.","Targeted therapies significantly increase the efficiency of cancer therapy. They bring great benefit to patients because they improve survival rates with much less side effects than traditional cytotoxic therapies. Small molecule inhibitors of protein kinases are a prime example of the success of targeted therapy. There are currently (Nov. 2013) twenty-five kinase inhibitor drugs approved for clinical use, all except two for cancer ( and ).","false","true","0.16091967","3","3","3","Rambam Maimonides Med J","Transoral Robotic Surgery in the HPV Era","Gil, Ziv","The rate of head and neck squamous cell carcinoma (HNSCC) has been increasing recently secondary to an epidemic of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC).– HPV-positive OPSCC has a unique demographic, risk factor profile, and tumor biology. The incidence of tonsil and base of tongue cancers is approximately 2 per 100,000 with an incidence increase of 3.9% and 2.","false","false","0.07372098","2","2","4","J Immunother Cancer","Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study","Klinke, David J","Following the early clinical observations of William B. Coley, harnessing the immune system to cure cancer has been difficult to achieve in the clinic. Recent FDA approval of immune checkpoint modulators for cancer has renewed enthusiasm in multiple communities. Patient groups are excited about the prospect for a cure. For patients with a historically poor prognosis, like metastatic melanoma, immune checkpoint modulators provide real hope for a favorable outcome following treatment.","false","false","0.22281712","2","2","1"
"23","SAME_AUTHOR","PLoS ONE","Gastrointestinal Symptoms in HIV-Infected Patients: Female Sex and Smoking as Risk Factors in an Outpatient Cohort in Brazil","Paraskevis, Dimitrios","Despite the decline in the number of new cases of HIV infection in recent years, the number of people living with HIV/AIDS (PLWHA) is increasing. In a global perspective, the number of individuals living with the disease now exceeds 35 million []. In Brazil, there are currently 718,000 PLWHA, and in the last ten years, 37,446 cases on average were reported per year [].The increasing number of PLWHA is mainly due to the use of antiretroviral drugs to treat HIV infection, contributing to a significant reduction in morbidity and mortality related to HIV.","PLoS ONE","Post-ART Symptoms Were Not the Problem: A Qualitative Study on Adherence to ART in HIV-Infected Patients in a Mozambican Rural Hospital","Paraskevis, Dimitrios","In 2007, an estimated 33 million people were infected with HIV, of which two-thirds were living in sub-Saharan Africa []. The number of new HIV infections has globally declined over the past decade but an estimated 35 million people world-wide were living with HIV by the end of 2013 [].In Mozambique, the national estimated HIV prevalence in adults was 12.5% in 2007 [] and 10.8% in 2013 []. In the country, antiretroviral treatment (ART) coverage has increased from 88,211 (24%) in 2007 [,] to 456,055 (33%) in 2013 [].","true","true","0.39832354","2","2","3","PLoS ONE","Molecular Features Related to HIV Integrase Inhibition Obtained from Structure- and Ligand-Based Approaches","van Veen, Hendrik W.","According to the latest UNAIDS (Joint United Nations Program on HIV/AIDS) global report, 34 million people were infected with HIV at the end of 2011. Although the number of newly infected people worldwide has been decreasing by 20% since 2001, in some parts of the world as Middle East and North Africa this number has increased by more than 35% . Mainly due to antiretroviral therapy, the number of people dying from AIDS-related causes is also decreasing worldwide, with an estimated 24% decline since 2005.","false","true","0.43031725","2","2","1","PLoS ONE","Virulence of  Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of  katG Mutants and the Possible Role of AhpC","Karakousis, Petros C.","Tuberculosis (TB) has killed more people than any other infectious disease in history. In the last century, the number of deaths due to TB has declined due to the discovery of anti-TB chemotherapy, but HIV coinfection as well as the increasing number of drug resistant cases has worsened the global burden of the disease []. Isoniazid (INH) is one of the most effective drugs within a multi-drug regimen to treat patients with active TB.","false","true","0.30616182","2","4","4","PLoS ONE","HIV-DNA Given with or without Intradermal Electroporation Is Safe and Highly Immunogenic in Healthy Swedish HIV-1 DNA/MVA Vaccinees: A Phase I Randomized Trial","Lama, Javier R.","Globally in 2012, UNAIDS estimated that 35.3 (32.2–38.8) million people were living with HIV. The number of new infections declined 33% since 2001 to 2.3 (1.9–2.7) million in 2012. The number of AIDS deaths had also declined to 1.6 (1.4–1.9) million in 2012 from 2.3 (2.1–2.6) million in 2005. These changes reflect an increased access of antiretroviral therapy globally. However, HIV antiretroviral treatment coverage in low-and middle-income countries amounted to only 34% (32–37%) of the 26.","false","true","0.36571318","2","2","2"
"24","SAME_AUTHOR","PLoS ONE","Genetic Diversity of  Mycobacterium tuberculosis Isolates from Tibetans in Tibet, China","Mokrousov, Igor","Tuberculosis (TB) remains a major health problem in China. A 2000 national TB epidemiology survey conducted in China reported the average prevalence of TB amounts to 367 per 100,000 (0.0036%), with an estimated 4.5 million active pulmonary TB patients and 1.5 million new infections a year . The prevalence rate of TB in western China was higher than central and eastern regions of the country. Furthermore, the increase of multi-drug resistant (MDR) TB in China inhibits the cure/treatment of the disease.","PLoS ONE","Genetic Diversity of  Mycobacterium tuberculosis from Guadalajara, Mexico and Identification of a Rare Multidrug Resistant Beijing Genotype","Manganelli, Riccardo","It is estimated that a third of the world’s population is infected with Mycobacterium tuberculosis and over 9 million new tuberculosis (TB) cases are diagnosed annually []. In Mexico, more than 2000 people die every year from TB, and the rate is 16.8 cases per 100,000 in 2010. In the western state of Jalisco, the TB rate was 13 per 100,000 []. Multidrug-resistant strains of M. tuberculosis (MDR-TB) resistant to isoniazid (INH) and rifampicin (RIF) are a challenge for clinicians.","false","true","0.4872916","1","2","2","PLoS ONE","“My Favourite Day Is Sunday”: Community Perceptions of (Drug-Resistant) Tuberculosis and Ambulatory Tuberculosis Care in Kara Suu District, Osh Province, Kyrgyzstan","Mokrousov, Igor","Each year, more than nine million people develop active TB, and nearly two million TB patients die. Multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) are major threats to TB control, and all countries can be considered at risk of developing resistant TB. The standard six-month treatment with first-line anti-TB drugs is not effective for people with MDR-TB and XDR-TB. Instead, they must be treated with drugs that are less efficacious, more toxic and much more costly (typically, US$ 2000–5000 per patient).","true","true","0.59405243","2","3","2","PLoS ONE","Population-Based Drug Resistance Surveillance of Multidrug-Resistant Tuberculosis in Taiwan, 2007-2014","Sola, Christophe","Tuberculosis (TB) is a major infectious disease worldwide. The World Health Organization (WHO) estimated that there are 9.6 million new TB cases and 1.5 million deaths annually []. In 2014, there were 11,326 new TB cases and 591 deaths were notified in Taiwan. The incidence rate was 48.4 cases per 100,000 populations. The TB incidence increased with age and 52.1% of new TB cases were in the age group of 65 years old or over.","false","true","0.4593354","3","1","2","PLoS ONE","Tuberculosis Trends in Saudis and Non-Saudis in the Kingdom of Saudi Arabia – A 10 Year Retrospective Study (2000–2009)","Caylà, Joan A.","Despite the declaration of tuberculosis (TB) as a global emergency by the World Health Organisation (WHO) in 1993 , TB caused 1.45 million deaths in 2010 and remains a major international health problem. Globally, the average incidence rate of TB peaked at 142 cases per 100,000 people in 2004. Since then, it has fallen by approximately 1 per cent a year, reaching 137 cases per 100,000 people in 2009 .","false","true","0.39566997","4","4","2"
"25","DIFFERENT_JOURNAL","PLoS ONE","Genome-Wide Analysis and Characterization of Aux/IAA Family Genes in  Brassica rapa","Li, Maoteng","Auxin is the most important hormone involved in many plant organ development processes like root, flower, leaf and fruit, and regulates plant responses including phototropism, gravitropism, apical dominance and cell elongation [, ]. Auxin/indole-3-acetic acid (Aux/IAA) hormones are primary responsive auxin genes that are short-lived and localize in nucleus, conversely some Aux/IAA proteins are long-lived and not degraded easily.","PLoS Genet","The  Arabidopsis IDD14, IDD15, and IDD16 Cooperatively Regulate Lateral Organ Morphogenesis and Gravitropism by Promoting Auxin Biosynthesis and Transport","Yu, Hao","Auxin is a key plant hormone that plays critical roles in the regulation of plant growth and development. A combination of physiological, genetic, biochemical, and molecular studies has greatly enriched our understanding of auxin biosynthesis, transport, and signal transduction –. Increasing evidence indicates that auxin is essential for nearly all developmental processes, including gametogenesis, embryogenesis, lateral organ formation and patterning, branching, and tropic responses , .","false","false","0.3630541","2","2","1","PLoS ONE","2,4-D and IAA Amino Acid Conjugates Show Distinct Metabolism in  Arabidopsis","Rahman, Abidur","The distribution of the phytohormone auxin (indole-3-acetic acid, IAA) mediates most aspects of plant development by triggering molecular processes, which control organogenesis in response to environmental and development cues. Auxin regulation of gene expression occurs by the action of the nuclear-localized F-box proteins TRANSPORT INHIBITOR RESPONSE 1/AUXIN SIGNALING F-BOX (TIR1/AFB), which promote the degradation of the AUXIN/INDOLE-3-ACETIC ACID (Aux/IAA) transcriptional repressors in an auxin-dependent manner via the ubiquitin-proteasome system (UPS) [].","false","true","0.52321666","3","3","3","PLoS ONE","mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer","Tan, Ming","The ‘HER2-positive’ subtype of breast cancer overexpresses the human epidermal growth factor receptor 2 (HER2). This receptor tyrosine kinase is part of the epidermal growth factor receptor (EGFR) family, further including HER1 (EGFR), HER3 and HER4 []. It is overexpressed in 10–20% of breast tumors, and the related subtype is associated with increased recurrence and mortality rates [, ].The humanized monoclonal antibody trastuzumab targets specifically the extracellular domain of HER2 and is part of the adjuvant treatment of patients with HER2-positive (HER2+) early breast cancer [].","false","true","0.011458731","1","1","2","PLoS ONE","OsARF16 Is Involved in Cytokinin-Mediated Inhibition of Phosphate Transport and Phosphate Signaling in Rice ( Oryza sativa L.)","Wu, Keqiang","The phytohormone, auxin, governs many aspects of growth, development and nutrient homeostasis in plants. Auxin perception and signal transduction regulate the expressions of many downstream genes via the AUXIN (AUX)/INDOLE-3ACETIC ACID (IAA) and AUXIN RESPONSE FACTOR (ARF)-mediated auxin signaling pathways . ARFs, which regulate the expression of auxin-responsive genes, are involved in all the developmental processes from embryogenesis to senescence .","false","true","0.4930787","2","4","3"
"26","SAME_AUTHOR","PLoS ONE","Long Non-Coding RNA ucoo2kmd.1 Regulates CD44-Dependent Cell Growth by Competing for miR-211-3p in Colorectal Cancer","Zhou, Yifeng","Colorectal cancer (CRC) is an important public health problem globally and remains a major cause of cancer mortality in the developed world, largely due to its propensity to metastasize[]. It is the second most common cancer diagnosis among women and the third most common among men[]. Although the achievements in colorectal cancer research are remarkable, new and effective therapeutic strategies are still needed.","PLoS ONE","Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring  ST13 Gene","Han, Zhaozhong","Cancer is a major global public health concern. A total of 1,529,560 new cancer cases and 569,490 deaths from cancer occurred in the United States alone in 2010 . Colorectal cancer is the second highest cause of death in the USA and is the fourth most common cancer in men and the third most common cancer in women worldwide . Thus, it is essential for scientists and medical doctors to develop new strategies for colon cancer treatment.","false","true","0.6407116","3","2","1","PLoS ONE","APRIL Induces Tumorigenesis and Metastasis of Colorectal Cancer Cells via Activation of the PI3K/Akt Pathway","Costa-Neto, Claudio M.","Colorectal cancer (CRC) is a major public health problem in the United States and globally. In the United States, it is the third most common cancer and the third leading cause of cancer mortality if men and women are considered separately . Occurrence of metastases due to tumor progression is the cause of the majority of cancer-related deaths. Despite much progress in diagnostic and therapeutic methodology, the prognosis for CRC patients remains poor.","false","true","0.60398704","3","1","3","PLoS ONE","Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells","Ouellette, Michel M","Colorectal cancer (CRC) is the third most common malignancy and fourth most common cause of cancer deaths worldwide, with an estimated 1.23 million new cases of CRC diagnosed and a mortality of 608000 in 2008. It is the third most common cancer in men and the second in women worldwide [–]. In Malaysia, CRC is the second most common cancer related mortality after breast cancer based on the Malaysia Cancer Statistics 2006 [].","false","true","0.63289505","3","2","2","PLoS ONE","cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/β-Catenin Pathway","Zhou, Yifeng","Colorectal cancer (CRC) is a malignant neoplasm that is situated in the colon or rectum [, ]. CRC remains a major cause of cancer mortality in the developed world, largely due to its propensity to metastasize []. CRC poses a major public health problem, as it is the third most commonly diagnosed cancer in males and the second most common in females. There have been many comparative studies demonstrating epigenetic changes closely associated with the occurrence and development of CRC.","true","true","0.6103001","3","3","4"
"27","DIFFERENT_JOURNAL","PLoS ONE","Risk Environments, Race/Ethnicity, and HIV Status in a Large Sample of People Who Inject Drugs in the United States","Yuhua, Ruan","HIV epidemics are heterogeneous across populations and places [,]. In the United States (US) in 2011, estimated rates of newly diagnosed HIV cases among people who inject drugs (PWID) were eleven times as high among black PWID (230/100,000), and six times as high among Latino PWID (121/100,000), as among white PWID (21/100,000) []. The Centers for Disease Control and Prevention (CDC) and the National HIV/AIDS Strategy prioritized eliminating racial/ethnic disparities in HIV incidence among PWID and other key populations, and highlighted the role of place characteristics (a term used interchangeably here with “environmental features”) in creating disparities [,].","PLoS ONE","Risk Behaviors and Risk Factors for HIV Infection among Participants in the Bangkok Tenofovir Study, an HIV Pre-Exposure Prophylaxis Trial among People Who Inject Drugs","Sued, Omar","HIV spread rapidly among people who inject drugs (PWID) in Bangkok in the late 1980s  and HIV prevalence has remained high, ranging from 30% to 50% through 2009, the highest among risk populations surveyed . During 2005–2012, we conducted the Bangkok Tenofovir Study (BTS), a randomized, double-blind, placebo-controlled trial, that showed that daily prophylaxis with tenofovir disoproxil fumarate (tenofovir) could reduce the risk of HIV infection among PWID , .","false","true","0.42155734","1","2","3","PLoS ONE","What Drives the US and Peruvian HIV Epidemics in Men Who Have Sex with Men (MSM)?","Sullivan, Patrick S.","Three decades on, the HIV epidemic in the United States and other highly developed nations remains concentrated among men who have sex with men (MSM), with over half of new infections occurring in this community . The same is true throughout Latin America . In the US, HIV incidence is rising among young MSM, especially Blacks . Incidence trends for Latin American MSM are less well characterized, although prevalence remains high in this community throughout the region .","false","true","0.2932893","2","2","3","PLoS ONE","Dietary Mushroom Intake May Reduce the Risk of Breast Cancer: Evidence from a Meta-Analysis of Observational Studies","Katoh, Masaru","Breast cancer is the most common cancer and the leading cause of cancer death for female in both developed and developing countries, accounting for 23% of the total new cancer cases and 14% of the total cancer deaths in 2008 . The high prevalence and incidence have led to a large public health burden all over the world, thus more attention should be paid to the primary prevention of breast cancer.Lifestyle factors are considered to play an important role in the prevention of breast cancer since they could be modified .","false","true","0.0574485","3","2","3","PLoS ONE","Examining Levels of Risk Behaviors among Black Men Who Have Sex with Men (MSM) and the Association with HIV Acquisition","Rosenberg, Eli Samuel","Black men who have sex with men (MSM) are disproportionately affected by the HIV epidemic in the United States (US). Approximately one quarter of all new HIV infections in the US occur among Black MSM []. Moreover, the Centers for Disease Control and Prevention (CDC) reports a 48% increase in HIV incidence among young black MSM between 2006 and 2009 []. Due to the disproportionate impact of HIV on Black MSM, HIV prevention has become a key focus area in addressing HIV-related health disparities among this group.","false","true","0.43790933","1","2","2"
"28","DIFFERENT_JOURNAL","PLoS ONE","Identifying the Dominant Personality Profiles in Medical Students: Implications for Their Well-Being and Resilience","Cipresso, Pietro","The high prevalence of stress, anxiety, burnout and depression among medical students is increasingly documented [–]. Hojat and colleagues have shown how humanistic components of clinical competence, such as empathy and other, interpersonal skills, can be eroded in medical students who are vulnerable to the rigors of medical training [, ]. There is growing awareness of threats to student health with many schools introducing or testing interventions and development programs to nurture and maintain overall well-being [–].","PLoS ONE","Family and College Environmental Exposures Mediate the Relationship between Parental Education and Depression among College Students","Vrana, Kent E.","Lower socioeconomic status is associated with poorer health, including depression []. Depression is common among higher-education students []. The prevalence of depression in college students is high, at approximately 15% []. A large number of depressive college students experience adverse consequences, including suicide, which is the leading cause of death among college students []. According to the American College Health Association, 10% of college students have experienced suicidal ideation, mostly as a result of depression.","false","true","0.30918282","3","3","2","PLoS ONE","Prevalence of Anxiety and Depressive Symptoms and Related Risk Factors among Physicians in China: A Cross-Sectional Study","Harper, Diane M.","Physicians are vulnerable to some mental disorders such as anxiety, depression, and occupational burnout, likely owing to their exposure to high levels of occupational stress , . Adverse mental health among physicians can hinder their professional performance and affect the quality of healthcare provided –. These issues will inevitably have negative effects on patients’ health and the development of healthcare system based on manpower sources , .","false","true","0.21134098","3","3","3","Medicine (Baltimore)","Bisphosphonates in the Treatment of Patients With Metastatic Breast, Lung, and Prostate Cancer","Wang., Hsueh","Lung cancer, breast cancer, and prostate cancer remain the leading cause for cancer mortality worldwide. Lung cancer has an incidence in Europe of 417,000 new cases per year, and a mortality/incidence ratio of 0.88. Breast cancer is the most common cancer type in women worldwide and is the main cause of cancer mortality in women in the world. Prostate cancer is the most common cancer in men in many western countries, and the second leading cause of cancer death in men.","false","false","0.009048385","2","3","3","PLoS ONE","Predictors of Participation of Sophomore Medical Students in a Health-Promoting Intervention: An Observational Study","Duan, Wenjie","The medical degree is often described as a particularly demanding programme. In addition to non-specific academic and all-day life stress, specific medical school stressors can serve as negative input to the so-called medical students’ coping reserve []. In combination with certain personality and temperament factors specific to medical students and / or physicians, such as obsessionality and compulsiveness [], these stressors can lead to an increased risk of developing depression, anxiety, burnout and other stress-related illnesses [–].","false","true","0.40008166","2","3","2"
"29","SAME_AUTHOR","PLoS Pathog","The SH3BGR/STAT3 Pathway Regulates Cell Migration and Angiogenesis Induced by a Gammaherpesvirus MicroRNA","Lieberman, Paul M","Kaposi’s sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus associated with AIDS-associated Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD) []. KS is an angiogenic vascular tumor of endothelial spindle cells []. KS is characterized by vast aberrant proliferation of small vessels, lack of basement membrane, and excessive leakiness with microhemorrhages and hemosiderin deposition [].","PLoS Pathog","A Gammaherpesvirus Uses Alternative Splicing to Regulate Its Tropism and Its Sensitivity to Neutralization","Hutt-Fletcher, Lindsey","Gammaherpesviruses are ubiquitous pathogens in human and animal populations all over the world. The best studied gammaherpesviruses, the Epstein-Barr virus (EBV) and the Kaposi's sarcoma-associated herpesvirus (KSHV), infect respectively some 90%  and 30%  of human populations. Primary infections by these viruses are usually subclinical, however, long-term carriage of these viruses can be associated with the development of various malignancies ,  such as Burkitt lymphoma, nasopharyngal carcinoma, primary effusion lymphoma or Kaposi's sarcoma.","false","true","0.32496685","1","2","2","PLoS Pathog","Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic Replication","Lieberman, Paul M","Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human tumor virus in the family of gamma2-herpesviruses. KSHV is the etiologic agent of Kaposi’s sarcoma (KS) and other KSHV-associated lymphoproliferative diseases such as primary effusion lymphoma (PEL) [,]. KSHV genome consists of linear double-stranded DNA (dsDNA), and like other herpesviruses, the virus displays two modes of infection in the infected cells, the latent and lytic replication phase.","true","true","0.44265783","2","2","1","PLoS ONE","A microRNA Encoded by Kaposi Sarcoma-Associated Herpesvirus Promotes B-Cell Expansion  In Vivo","Simas, J. Pedro","Kaposi sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), a tumor of endothelial origin, as well as the lymphoproliferative disorders primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD) –. Like all herpesviruses, KSHV can establish long-term latent infections of its host cell. The natural target cell of KSHV infection in vivo is the B-cell, and latently infected memory B-cells are thought to represent a reservoir that is of importance for the lifelong KSHV persistence.","false","false","0.44456795","2","1","3","PLoS ONE","Proteomic Characterization of Murid Herpesvirus 4 Extracellular Virions","Favoreel, Herman","The Herpesviridae is a large family of DNA viruses, including eight identified human herpesviruses. The gammaherpevirinae is one of the three subfamilies of the Herpesviridae. Two gammaherpesviruses are known to infect humans, Epstein-Barr virus (EBV) and the Kaposi’s sarcoma-associated herpesvirus (KSHV), which are associated with various types of cancer such as Burkitt’s lymphoma, nasopharyngeal carcinoma, Kaposi’s sarcoma or Castleman’s disease , .","false","false","0.3459696","4","4","4"
"30","SAME_AUTHOR","PLoS ONE","C/EBPα Short-Activating RNA Suppresses Metastasis of Hepatocellular Carcinoma through Inhibiting EGFR/β-Catenin Signaling Mediated EMT","Avila, Matias A","Liver cancer is the fifth most frequent cancer and the second leading cause of cancer death worldwide in men []. An estimated 422100 people die from liver cancer and more than 466100 new cases are diagnosed each year in China []. Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and high frequencies of postoperative recurrence and metastasis mainly result in the poor prognosis [].","PLoS ONE","Establishment and Characterization of 7 Novel Hepatocellular Carcinoma Cell Lines from Patient-Derived Tumor Xenografts","Mukhopadhyay, Partha","Liver cancer is one of the most common cancers worldwide. Based on a global cancer statistics study, liver cancer represents the fifth most frequently diagnosed cancer and the second most frequent cause of cancer death in men. It is the seventh and sixth in women respectively. The majority of new cases and deaths come from developing countries, such as China and India. Hepatocellular carcinoma (HCC) accounts for 70% to 80% of primary liver cancers in adults.","false","true","0.7682808","3","2","2","PLoS ONE","Risk of Primary Liver Cancer Associated with Gallstones and Cholecystectomy: A Meta-Analysis","Mittal, Balraj","Primary liver cancer mainly includes hepatocellular carcinoma (HCC), which originates in liver cells, and intrahepatic cholangiocarcinoma (ICC), which arises from the intrahepatic bile duct . The worldwide burden of primary liver cancer for 2012 was estimated at 782,000 new cancer cases . It ranks as the fifth most common incident cancer in men and the ninth in women . Owing to its poor prognosis, it is the second commonest cause of death from cancer worldwide .","false","true","0.7063463","2","1","3","PLoS ONE","MiR-199a Regulates Cell Proliferation and Survival by Targeting FZD7","Guan, Xin-Yuan","Hepatocellular carcinoma (HCC), the most common primary liver cancer , is one of the most prevalent malignant diseases and the second-most frequent cause of cancer deaths worldwide . Half of the new liver cancer cases and liver cancer deaths worldwide were estimated to occur in China . The dismal prognosis of advanced HCC is largely caused by late detection of the tumors and its high rate of recurrence and metastasis , , .","false","true","0.7454962","4","1","4","PLoS ONE","Regulation of Multidrug Resistance Proteins by Genistein in a Hepatocarcinoma Cell Line: Impact on Sorafenib Cytotoxicity","Avila, Matias A","Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. It ranks as the fifth most frequent cancer and the third leading cause of cancer mortality worldwide []. The traditional management of HCC depends on the stage at which the disease is diagnosed and consists of surgical resection, ablation or liver transplantation []. Conventional chemotherapy with agents such as 5-fluorouracil, epirubicin and doxorubicin has been applied as palliative treatment but survival improvement in the majority of the patients is negligible [].","true","true","0.54189557","1","1","4"
"31","DIFFERENT_JOURNAL","PLoS Genet","The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts","Irvine, Kenneth","The Hippo Pathway (also called the Salvador-Warts-Hippo Pathway) plays a well-appreciated and strongly conserved developmental role in establishing and maintaining organ size. Aberrations in signaling pathways can increase rates of cellular growth or proliferation, but once appropriate organ size is reached, what is coming to be called an “organ size checkpoint” blocks further growth and proliferation; organs do not overgrow unless these aberrations also bypass the “organ size checkpoint” [].","PLoS Biol","Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association","Basler, Konrad","The control of organ size, which requires the delicate coordination of cell growth, cell proliferation, and cell death, is a fascinating biological process. The identification of the Hippo (Hpo) signaling pathway has shed some light on this biological phenomenon. The Hpo pathway has emerged as an evolutionarily conserved pathway that controls organ size during animal development. It regulates tissue growth by balancing cell proliferation and apoptosis and has also been implicated in stem cell maintenance, tissue homeostasis, and repair –.","false","false","0.3904762","4","4","2","PLoS ONE","Mechanical Control of Organ Size in the Development of the Drosophila Wing Disc","Merks, Roeland M. H.","Control of organ size and growth is a fundamental open question in developmental biology . While a wealth of knowledge on biochemical pathways and their genetic control has been accumulated over the last decades, several issues in organ growth, in particular the question of the cessation of growth, remain unanswered. A widely used model system for the study of organ growth control is the wing imaginal disc of Drosophila , which is the larval precursor organ that becomes the wing of the adult fly during metamorphosis.","false","false","0.37451267","3","3","3","PLoS ONE","Genome-Wide Identification, Characterization and Evolutionary Analysis of Long Intergenic Noncoding RNAs in Cucumber","Zheng, Yun","The majority of the genome can be transcribed into RNA, but only a small fraction of these transcripts can be translated into proteins [–]. In addition to protein-coding RNA, tRNA, rRNA, and many small noncoding RNAs have been discovered, including miRNA, siRNA and piRNA [, ]. Long intergenic noncoding RNAs (lincRNAs) are a newly described type of noncoding RNA derived from the intergenic regions of the genome [–].","false","false","0.02182179","3","1","4","PLoS ONE","Scribble Acts in the  Drosophila Fat-Hippo Pathway to Regulate Warts Activity","Nam, Sang-Chul","Growth and differentiation need to be precisely controlled during development to generate organs of appropriate size . The Hippo pathway has emerged as a pathway that regulates growth and organ size in Drosophila and mammals , , , . The Hippo pathway regulates organ size by controlling the activity of the transcriptional co-activator Yki in flies (and YAP/TAZ in mammals), which is an important regulator of proliferation and apoptosis , , , .","false","false","0.5261341","2","2","1"
"32","SAME_AUTHOR","PLoS ONE","Recruitment Variability of Coral Reef Sessile Communities of the Far North Great Barrier Reef","Ferse, Sebastian C. A.","Coral reefs exhibit remarkable biodiversity []. Although the conspicuous scleractinian corals form key structural components of coral reefs numerous other groups play important functional roles. Notably, reef-consolidating algae [] and sponges play vital roles in nutrient cycling and aid in benthic-pelagic energy coupling []. The underlying resilience of coral reefs, in part, relies on the maintenance and persistence of these coral reef communities through space and time [], particularly for sessile benthic taxa with dispersive larval or propagule phases.","PLoS ONE","Life History Changes in Coral Fluorescence and the Effects of Light Intensity on Larval Physiology and Settlement in  Seriatopora hystrix","Ferse, Sebastian C. A.","Coral reefs are now threatened on a global scale due to anthropogenic climate change as well as local stressors , . Scleractinian corals create the foundation of coral reefs. Therefore, the future of coral reefs, one of the most productive and diverse ecosystems on our planet, is dependent on the reproductive success of scleractinian corals. Most corals are broadcast-spawners, in which eggs are fertilized externally in the water column and larvae may be pelagic for long periods of time .","true","true","0.5012804","1","3","2","PeerJ","Variation in habitat soundscape characteristics influences settlement of a reef-building coral","Reimer, James","Coral reefs are one of the most diverse and productive ecosystems on Earth, supporting 25% of all marine fish in just 0.1% of ocean area, and providing far-reaching ecological and economic benefits (). The scleractinian corals that create the biogenic physical structure of reef habitat are fundamental to the existence of coral reef communities, and live coral abundance drives the ecological processes of a plethora of reef-dependent fish and invertebrates ().","false","false","0.4845551","2","4","4","PeerJ","Testing animal-assisted cleaning prior to transplantation in coral reef restoration","Costello, Mark","Active coral reef restoration is increasingly being seen as a new tool for conservation biology () as coral reefs continue to decline worldwide (). One of the several available coral reef restoration methods involves “coral gardening” in a two-step process. First, coral fragments are raised in underwater nurseries. Second, after reaching a target size, the nursery corals are harvested and transplanted onto degraded reef areas ().","false","false","0.503282","3","2","1","PLoS ONE","Quantifying Climatological Ranges and Anomalies for Pacific Coral Reef Ecosystems","Fulton, Christopher","Coral reef ecosystems are exposed to a suite of physical, chemical and biological environmental forcings that are highly variable across time and space , . Environmental forcings influence coral reef ecosystem process and function, including coral reef extent and growth rates and the abundance, diversity, and morphology of reef organisms . Over time, coral reefs have adapted to exist within a particular climatological range; an envelope of environmental forcings that is region-specific and governed by a reef's geographic location , .","false","true","0.497955","3","1","3"
"33","DIFFERENT_JOURNAL","PLoS ONE","Managing Osteoporosis: A Survey of Knowledge, Attitudes and Practices among Primary Care Physicians in Israel","Tordjman, Karen M.","Osteoporosis is a systemic skeletal disorder characterized by impaired bone quality and microstructural deterioration, leading to an increased propensity to fractures. This is a major health problem for older adults, who comprise an increasingly greater proportion of the general population. Over 10 million adults in the United States are estimated to have osteoporosis and an additional 43 million to have low bone mass [].","PLoS ONE","Oral Bisphosphonate Exposure and the Risk of Upper Gastrointestinal Cancers","Chen, Chi-Ling","Osteoporosis is an important global issue with the growing aging population. In the United States, an estimated 9 million adults have osteoporosis and at least 48 million adults have an increased risk of osteoporosis related to low bone mass []. Bisphosphonates, a class of drugs which decrease osteoclast-mediated bone resorption, are often prescribed to prevent and treat osteoporosis []. When not taken as instructed (i.","false","true","0.53321624","2","3","2","PLoS ONE","Increased Acquired Cholesteatoma Risk in Patients with Osteoporosis: A Retrospective Cohort Study","Isales, Carlos M.","Advances in healthcare and increases in life expectancy have caused osteoporosis and related fractures to become crucial health concerns worldwide, particularly among older adults []. The World Health Organization has emphasized the importance of osteoporosis. Osteoporosis-related fractures, which are prevalent in the older population, can lead to complications and even death. Osteoporosis is caused by reductions in bone mass and destruction of fine structures, which reduce the mechanical integrity of bone and increase the accumulation of noninvasive fractures [].","false","true","0.41629073","3","4","2","PLoS ONE","Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring  ST13 Gene","Han, Zhaozhong","Cancer is a major global public health concern. A total of 1,529,560 new cancer cases and 569,490 deaths from cancer occurred in the United States alone in 2010 . Colorectal cancer is the second highest cause of death in the USA and is the fourth most common cancer in men and the third most common cancer in women worldwide . Thus, it is essential for scientists and medical doctors to develop new strategies for colon cancer treatment.","false","true","0.05574947","2","2","2","PLoS ONE","Development and Validation of an Osteoporosis Self-Assessment Tool for Taiwan (OSTAi) Postmenopausal Women-A Sub-Study of the Taiwan OsteoPorosis Survey (TOPS)","Pérez, M. A.","Osteoporosis is a systemic skeletal disorder characterized by low bone mass and microarchitectural deterioration of bone tissue, and as a consequence, an increase in bone fragility and susceptibility to fracture [].Several previous studies concluded that advanced age and low body weight are strongly associated with osteoporosis and with increased fracture risk [–]. As life expectancy increased, osteoporosis has become a major public health problem worldwide.","false","true","0.47795212","2","1","2"
"34","SAME_AUTHOR","PLoS ONE","Association between Obstructive Sleep Apnea and Community-Acquired Pneumonia","Penzel, Thomas","Obstructive sleep apnea (OSA) is a highly prevalent disorder affecting between 10–50% of middle-aged men []. OSA is characterized by recurrent upper airway obstruction associated with cyclic changes in oxyhemoglobin saturation, intermittent arousals from sleep and alterations in intrathoracic pressure. These alterations induce oxidative stress, sympathetic activation, and metabolic dysregulation [].","PLoS ONE","Simulated Obstructive Sleep Apnea Increases P-Wave Duration and P-Wave Dispersion","Penzel, Thomas","Obstructive sleep apnea (OSA) is highly prevalent, with approximately 20% of males and 10% of females in Western countries affected by asymptomatic OSA. Pathophysiologically, the disease is characterized by repetitive partial or complete obstruction of the pharynx during sleep. Despite increasing breathing efforts the upper airway collapse results in episodes of obstructive hypopneas or apneas resulting in negative intrathoracic pressure, intermittent hypoxia, autonomic nervous dysfunction, and consequently adverse effects for sleep-architecture and health.","true","true","0.4796321","2","1","2","PLoS ONE","Integrative miRNA-mRNA Profiling of Adipose Tissue Unravels Transcriptional Circuits Induced by Sleep Fragmentation","Makishima, Makoto","Obstructive sleep apnea (OSA) is a highly prevalent disorder in adults and children – and associated with significant cognitive, metabolic, and cardiovascular morbidities –. OSA is characterized by recurrent collapse of the upper airway during sleep, leading to intermittent hypoxia and sleep fragmentation (SF). There is accumulating evidence that OSA is strongly linked to metabolic dysregulation, independent of obesity , .","false","true","0.5404325","3","3","1","PLoS ONE","Supra-Epiglottic Upper Airway Volume in Elderly Patients with Obstructive Sleep Apnea Hypopnea Syndrome","Wang, Yue","Obstructive sleep apnea syndrome (OSAS) is a type of sleep-disordered breathing characterized by repetitive complete or partial upper airway obstruction during sleep []. This common disorder is especially prevalent, occurring in approximately 24% of middle-aged and elderly adults [, ]. OSAS has been associated with nighttime hypertension [], reduced renal function [], cognitive impairment [], and nocturia in the elderly [, ].","false","true","0.46291006","3","2","3","PLoS ONE","Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea","Ashton, Nick","Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder that affects 15–24% of the adults and is associated with increased cardiovascular morbidity and mortality including hypertension . OSA is characterized by recurrent upper airway obstruction during sleep. These episodes are terminated by arousals and are commonly associated with hypoxemia. Current evidence suggests that inflammatory processes, oxidative stress and endothelial dysfunction may play roles in the pathogenesis of vascular complications of OSA .","false","true","0.5370861","1","4","2"
"35","DIFFERENT_JOURNAL","PLoS ONE","Transcription Factors Expressed in Mouse Cochlear Inner and Outer Hair Cells","Riley, Bruce B","While the genome is identical for nearly every cell in multicellular organisms, the gene expression profile for each cell is different. Diverse patterns of gene expression underlie phenotypic variances of different cell types [,]. Transcription factors (TFs) play an essential role in the complex regulation of gene expression patterns in each unique cell type []. A TF is a protein that binds to specific DNA sequence motifs, thereby controlling transcription of genetic information from DNA to mRNA [].","PLoS Genet","The Fission Yeast Homeodomain Protein Yox1p Binds to MBF and Confines MBF-Dependent Cell-Cycle Transcription to G1-S via Negative Feedback","Snyder, Michael","Transcript levels of many genes fluctuate periodically as a function of cell growth and division, peaking at specific phases of each cell cycle. Such cell cycle-regulated gene expression seems to be a universal feature of proliferating cells –. The best characterized transcriptional wave is induced during the G1/S transition, named ‘Start’ in yeast and ‘restriction point’ in mammalian cells, when cells commit to DNA replication and thus to a new cell-division cycle.","false","false","0.47593868","3","3","4","Mol. Biol. Cell","POS-1 and GLD-1 repress  glp-1 translation through a conserved binding-site cluster","Magin, Thomas M.","The physiology of a cell is governed by the identity and extent of genes that it expresses. Gene expression is regulated at the transcriptional, posttranscriptional, and posttranslational levels. Each aspect is important and necessary to ensure appropriate expression for a given cell type. The relative importance of each varies, depending on cell lineage and activity. For example, control of gene expression after transcription is of primary importance during early embryogenesis, when transcription is repressed due to continuous DNA replication (; ; ), and in cells in which physiology is partially decoupled from the nucleus due to size or morphology, such as neurons ().","false","false","0.5492316","2","3","1","PLoS ONE","A Dual TLR Agonist Adjuvant Enhances the Immunogenicity and Protective Efficacy of the Tuberculosis Vaccine Antigen ID93","Tyagi, Anil Kumar","Approximately two billion people are infected with Mycobacterium tuberculosis (M.tb.) the causative agent of tuberculosis (TB). In 2011 there were over 8 million cases of active TB leading to 1.5 million deaths worldwide. The only vaccine against TB, BCG limits childhood disease, but is variably effective against pulmonary TB in adults, with efficacy estimates ranging from 0 to 80% . Thus there is a pressing need for new vaccine candidates against this devastating disease.","false","true","0.01165631","3","2","2","PLoS Genet","Study of FoxA Pioneer Factor at Silent Genes Reveals Rfx-Repressed Enhancer at  Cdx2 and a Potential Indicator of Esophageal Adenocarcinoma Development","Reid, Brian","The development of a multicellular organism requires the formation of functionally distinct cell types through the differential activation of gene expression. Such gene expression programs are enabled by transcription factors that endow the progenitors with the competence to differentiate under the influence of inductive signals –. During pathogenesis, effectors that damage cells can lead to aberrant induction of gene expression, but in these cases less is known about the transcription factor networks that govern the competence for such changes.","false","false","0.43928578","2","3","3"
"36","SAME_AUTHOR","PLoS ONE","Comparison of In Vitro- and Chorioallantoic Membrane (CAM)-Culture Systems for Cryopreserved Medulla-Contained Human Ovarian Tissue","Katoh, Masaru","Cancer is one of the major death causes: in the USA alone a total of 1,596,670 new cancer cases will be reported in 2011, of which the projected number of cancer-related deaths were 571,950. Overall cancer incidence rates in women in the USA have been declining by 0.6% annually since 1998 . At the same time, the overall incidence rate for cancer in children aged 14 years and younger increased by 0.","Contemp Oncol (Pozn)","Intensity of recreational physical activity in different life periods in relation to breast cancer among women in the region of Western Pomerania","Kruk, Joanna","Breast cancer is recognized as the most frequently diagnosed cancer among women worldwide, accounting for 1,383 500 of the total new cancer cases and 458 400 of the total cancer deaths in 2008 []. Of these, 692 200 (50%) of the cases and 189 500 deaths (27.4%) occurred in developed countries. Poland is one of the countries with a medium incidence rate; in 2009 it was 15 752 new cancer cases and 5362 cancer deaths in 2010 [].","false","false","0.55481577","2","1","3","PLoS ONE","Long-Time Cooling before Cryopreservation Decreased Translocation of Phosphatidylserine (Ptd-L-Ser) in Human Ovarian Tissue","Ivanovic, Zoran","Cancer is one of the major death causes in the world. In the USA alone a total of 1,658,370 new cancer cases and 589,430 cancer deaths are projected to occur in 2015 []. The overall incidence rate for cancer in children aged 14 years and younger increased by 0.6% per year between 1998 and 2007 [].A similar trend has been observed in Europe. The current estimate for 2010 for Germany relates to a total of approximately 204,000 cancer cases in women, and every year in Germany, around 800 girls under age 15 are diagnosed with cancer [].","false","true","0.7157863","1","2","2","PLoS ONE","Dietary Mushroom Intake May Reduce the Risk of Breast Cancer: Evidence from a Meta-Analysis of Observational Studies","Katoh, Masaru","Breast cancer is the most common cancer and the leading cause of cancer death for female in both developed and developing countries, accounting for 23% of the total new cancer cases and 14% of the total cancer deaths in 2008 . The high prevalence and incidence have led to a large public health burden all over the world, thus more attention should be paid to the primary prevention of breast cancer.Lifestyle factors are considered to play an important role in the prevention of breast cancer since they could be modified .","true","true","0.49572942","2","1","3","PLoS ONE","Characterization of Ascites-Derived Ovarian Tumor Cells from Spontaneously Occurring Ovarian Tumors of the Chicken: Evidence for E-Cadherin Upregulation","Samant, Rajeev","Ovarian cancer is the fifth leading cause of cancer-related deaths in women –. According to an estimate by the National Cancer Institute, the number of new cases of ovarian cancer diagnosed in women will be 22,880 and deaths caused by ovarian cancer will be 15,500 by the end of 2012 . Although surgical and chemotherapeutic interventions have improved 5- year survival rate, the cure rate of all stages of ovarian cancer is less than 40% .","false","true","0.5490108","1","2","3"
"37","DIFFERENT_JOURNAL","PLoS ONE","Effects of Hormone Therapy on Brain Volumes Changes of Postmenopausal Women Revealed by Optimally-Discriminative Voxel-Based Morphometry","Alberich-Bayarri, Angel","The Women’s Health Initiative Memory Study (WHIMS) provided a unique opportunity for researchers to examine critical questions regarding the effects of hormone therapy (HT) on brain structure of postmenopausal women. Results from the WHIMS study [, , , ] indicated that conjugated equine estrogens, with and without progestin, increase the risk of dementia and have adverse effects on cognition in women aged 65 and over.","PLoS ONE","Monitoring the Early Signs of Cognitive Decline in Elderly by Computer Games: An MRI Study","Quinn, Terence J","It is well documented that an aging society is a general tendency in Europe as well as in the United States (USA). The number of people belonging to the population aged 65 or over has tripled in the last 50 years and this tendency is expected to continue in the next 50 years []. Dementia is more frequent among women, some form of dementia occurs in 11% of men and 16% of women over the age of 71. Data on the prevalence of dementia are varying but studies are consistent in indicating the increasing prevalence of the disease in older age.","false","true","0.28586018","2","1","3","Ann Indian Acad Neurol","Mild cognitive impairment: Profile of a cohort from a private sector memory clinic","Srinivasan, Srikanth","Mild cognitive impairment (MCI) represents the intermediate stage between normal ageing and dementia. Patients diagnosed with MCI have cognitive impairment in excess of that expected for age and some limitation in complex functional activities, but do not warrant a diagnosis of dementia.[] In a substantial percentage of subjects, MCI is the pre-dementia stage. It has been estimated to affect 15-25% of community dwelling elderly over the age of 65 years and carries a higher risk of functional dependence and excess mortality in those affected.","false","false","0.17248787","2","1","1","PLoS ONE","GPR30, the Non-Classical Membrane G Protein Related Estrogen Receptor, Is Overexpressed in Human Seminoma and Promotes Seminoma Cell Proliferation","Migliaccio, Antimo","Testicular germ cell cancer is the most frequent cancer occurring in young men and originates from transformed gonocytes or undifferentiated spermatogonia , which respectively derived from foetal germ cells and adult germ stem cells. Seminomas are the most frequent (50–70%) testicular germ cell tumours. Clinical and experimental studies suggested that oestrogens, the archetype of female hormones, participate in the physiological and pathological control of male germ cell proliferation , .","false","true","0.066755734","1","2","2","PLoS ONE","The Response of Cerebral Cortex to Haemorrhagic Damage: Experimental Evidence from a Penetrating Injury Model","Norris, Christopher Mark","Recent advances in cerebral imaging have provided evidence that haemorrhage occurs in the brain not only in clinically evident haemorrhagic stroke, but also in clinically ‘silent’ microbleeds or ‘silent strokes’ which, like stroke, occur with increasing frequency with age , and contribute to the dementia of the aged , . Neuropathological studies , , , ,  have provided evidence that haemorrhage from or dysfunction of cerebral capillaries may be important in the formation of the plaques characteristic of age-related dementia (Alzheimer’s disease) , , , and risk-factor analyses indicate that age-related dementias are strongly vascular.","false","true","0.23141676","3","2","4"
"38","SAME_JOURNAL","PLoS ONE","Role of Breastfeeding and Complementary Food on Hemoglobin and Ferritin Levels in a Cambodian Cross-Sectional Sample of Children Aged 3 to 24 Months","Cardoso, Marly Augusto","Iron deficiency is estimated to be globally the most common cause of anemia. [] The World Health Organization (WHO) estimates that worldwide about 50% of all anemia can be attributed to iron deficiency which derives from an imbalance between intake and needs, with factors such as low bioavailability of dietary iron and high requirements due to growth and blood loss. [] Pregnant women and young children are especially vulnerable to iron deficiency.","Clin Exp Gastroenterol","Iron deficiency anemia in patients with inflammatory bowel disease","Goldberg, Neil D","Iron deficiency anemia is the most common form of anemia worldwide, representing up to 50% of all cases. In the United States, approximately 2% of men and 5% of women are believed to be affected. Causes of iron deficiency include poor iron intake, chronic blood loss, impaired absorption, or any combination of the three ().– Blood loss from the gastrointestinal (GI) tract is the most common cause in men and postmenopausal women and is a common reason for referral to a gastroenterologist.","false","false","0.5312127","1","1","3","PLoS ONE","Antenatal Iron Supplementation Regimens for Pregnant Women in Rural Vietnam and Subsequent Haemoglobin Concentration and Anaemia among Their Infants","Cardoso, Marly Augusto","Anaemia, often caused by iron deficiency, is highly prevalent among women and children in low- and middle-income countries (LAMIC) []. The World Health Organization (WHO) recommends that pregnant women take antenatal iron-folic acid supplements (IFA, daily dose of 60 mg of elemental iron and 400 μg of folic acid starting as soon as possible after gestation begins []) to maintain robust iron stores and prevent the development of anaemia.","true","true","0.40849122","2","4","2","PLoS ONE","Effect of Erythropoietin, Iron Deficiency and Iron Overload on Liver Matriptase-2 (TMPRSS6) Protein Content in Mice and Rats","Pantopoulos, Kostas","Iron deficiency is the most common cause of anemia worldwide. Although most cases of iron deficiency anemia respond to oral iron supplementation, some patients suffer from iron-refractory iron deficiency anemia, which is refractory to dietary iron, and can be only partly corrected by parenteral iron administration []. Seven years ago it was discovered that this anemia can be caused by mutations in the TMPRSS6 gene [–] which result in inappropriately high expression of hepcidin, the key iron-regulatory hormone [].","false","true","0.62406975","3","2","1","PLoS Negl Trop Dis","Elimination of Iron Deficiency Anemia and Soil Transmitted Helminth Infection: Evidence from a Fifty-four Month Iron-Folic Acid and De-worming Program","Gregson, Aric","Iron deficiency is one of the most common nutritional deficiencies affecting women of reproductive age and children . The increased demand for iron in these groups is often exacerbated by limited intake of heme iron, and hookworm infection with associated gastrointestinal blood loss. Globally, 42% of pregnant women are anemic with iron deficiency being the most common cause . Maternal iron deficiency anemia is associated with intra-uterine growth retardation, low birth weight, preterm birth, and increased risk of maternal and infant mortality .","false","false","0.57428885","4","3","4"
"39","SAME_JOURNAL","PLoS Pathog","Nonclassical MHC Ib-restricted CD8+ T Cells Recognize  Mycobacterium tuberculosis-Derived Protein Antigens and Contribute to Protection Against Infection","Lewinsohn, David M.","Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb), remains one of the world’s deadliest communicable diseases, with 1.5 million deaths annually []. Due to the emergence of multidrug-resistant Mtb strains, co-infection with HIV, and the failure of BCG vaccine to control adult pulmonary TB [, ], there is an urgent need for new and more effective TB vaccines. However, achieving this goal relies on further investigation of the properties of protective T cells during Mtb infection [].","PLoS ONE","A Phase I, Open-Label Trial, Evaluating the Safety and Immunogenicity of Candidate Tuberculosis Vaccines AERAS-402 and MVA85A, Administered by Prime-Boost Regime in BCG-Vaccinated Healthy Adults","Diemert, David Joseph","Tuberculosis (TB) remains a major global public health burden, with an estimated 9.0 million incident cases and 1.5 million deaths in 2013 []. Bacillus Calmette–Guérin (BCG), the only licensed vaccine, prevents disseminated disease in childhood. However, the protection conferred against pulmonary disease is highly variable [–]. A more effective vaccination strategy is urgently needed []. One potential strategy is to boost BCG with a recombinant viral vector encoding Mycobacterium tuberculosis (M.","false","false","0.44358194","2","4","1","PLoS Pathog","Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions","Lewinsohn, David M.","Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb) infection, remains a leading cause of morbidity and mortality worldwide . CD4+ and CD8+ T cells may be important for host immune resistance to TB in humans , , , . In mouse models of Mtb infection, IFN-γ and TNF-α produced by CD4+ and CD8+ T cells have been shown to be critical for immune control of Mtb infection , , .","true","true","0.5100786","2","1","3","PLoS Pathog","Novel Inhibitors of Cholesterol Degradation in  Mycobacterium tuberculosis Reveal How the Bacterium’s Metabolism Is Constrained by the Intracellular Environment","Boshoff, Helena Ingrid","There is an urgent need to identify new drugs to treat Mycobacterium tuberculosis (Mtb). The World Health Organization estimates that 1.8 billion people are infected with Mycobacterium tuberculosis (Mtb) and approximately 1.3 million people die from tuberculosis (TB) annually. The global prevalence of TB is sustained by the ongoing HIV-AIDS pandemic, poverty, and the emergence of antibiotic resistant isolates of Mtb [].","false","true","0.5060555","1","3","4","PLoS ONE","M mPPOX Inhibits  Mycobacterium tuberculosis Lipolytic Enzymes Belonging to the Hormone-Sensitive Lipase Family and Alters Mycobacterial Growth","Manganelli, Riccardo","According to the World Health Organization (2011; [http://www.who.int/tb/en/]), tuberculosis remains one of the most threatening and deadly disease in the world, with 8.8 million new infections and 1.5 million deaths in 2010. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis strains has made the current treatments less efficient. Therefore, the development of new pharmacological strategies to fight this disease are urgently needed .","false","false","0.4540206","4","2","2"
"40","SAME_JOURNAL","PLoS ONE","Apolipoprotein A-I Attenuates Palmitate-Mediated NF-κB Activation by Reducing Toll-Like Receptor-4 Recruitment into Lipid Rafts","Mukhopadhyay, Partha","Low levels of high-density lipoprotein (HDL) cholesterol are associated with increased risk of coronary artery disease and major cardiovascular events. HDL-raising strategies are being evaluated for the prevention and treatment of coronary artery disease. HDL may mediate atheroprotective effects by stimulation of eNOS-dependent NO production, mediation of endothelial repair, and promotion of cholesterol efflux from macrophage foam cells , , , , .","PLoS ONE","SR-BI in Bone Marrow Derived Cells Protects Mice from Diet Induced Coronary Artery Atherosclerosis and Myocardial Infarction","Schulz, Christian","The scavenger receptor class B type I (SR-BI) is a multiligand receptor that binds to high density lipoprotein (HDL) with high affinity and mediates the selective uptake of HDL lipids , cellular cholesterol efflux from cells  and HDL dependent signaling . SR-BI knockout (KO) mice exhibit defective HDL-dependent reverse cholesterol transport from macrophages, resulting in increased plasma HDL-associated cholesterol and reduced cholesterol in bile –.","false","true","0.49400666","4","3","3","Glob Cardiol Sci Pract","HPS2-THRIVE, AIM-HIGH and dal-OUTCOMES: HDL-cholesterol under attack","Hassan, Mohamed","A low level of high-density lipoprotein cholesterol (HDL-C) is an established predictor of the risk of coronary heart disease (CHD). HDL promotes cellular cholesterol efflux and reverse cholesterol transport from lipid-laden macrophages (), and prevents lipoprotein oxidation. A linear inverse relation has been reported in many observational studies between plasma HDL-C level and incident CHD events, with a plateau effect at HDL-C values >90 mg/dL in men and 75 mg/dL in women.","false","false","0.48862183","1","2","4","J Epidemiol","Dyslipidemia and Cardiovascular Disease: A Series of Epidemiologic Studies in Japanese Populations","Okamura, Tomonori","The causal relationships between high serum levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD) are well established in various ethnic populations.– In addition, serum high-density lipoprotein cholesterol (HDL-C) levels are known to be inversely associated with the risk of CAD. Therefore, in developed countries, serum cholesterol levels are the main target for lipid management in most guidelines developed to prevent atherosclerotic disease.","false","false","0.42716056","2","2","2","PLoS ONE","HDL Proteome in Hemodialysis Patients: A Quantitative Nanoflow Liquid Chromatography-Tandem Mass Spectrometry Approach","Mukhopadhyay, Partha","In the general population, a decrease in high-density lipoprotein (HDL) cholesterol and/or dysfunctional HDL is recognized as an important risk factor in cardiovascular (CV) diseases , . Several studies have focused on the protective effects of HDL on low-density lipoprotein (LDL) oxidation in the arterial wall . HDL is now recognized to protect against plaque formation and progression, in part, through the transport of cholesterol from the peripheral tissues to the liver .","true","true","0.46241486","2","3","1"
"41","SAME_JOURNAL","PLoS ONE","Assessing Local Risk of Rifampicin-Resistant Tuberculosis in KwaZulu-Natal, South Africa Using Lot Quality Assurance Sampling","Das, Gobardhan","In South Africa, the latest published estimates from a nationally representative tuberculosis (TB) drug resistance survey date back to 2002. At that time, 1.8% of new (treatment-naïve) TB cases and 6.7% of previously treated cases (i.e. individuals requiring re-treatment) were infected with multidrug-resistant (MDR) TB, defined by resistance to first-line drugs isoniazid and rifampicin []. While these risks are relatively are low compared to Eastern Europe (where the risk among new cases may exceed 25% and the risk among previously treated cases routinely exceeds 50%), South Africa is ranked sixth worldwide for absolute numbers of incident TB cases and therefore even low proportions of drug resistance translate into a high number of cases requiring treatment and risk for transmission of MDR TB [].","PLoS ONE","Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis","Das, Gobardhan","Every year nearly 8 million new cases of Tuberculosis (TB) are reported globally resulting in 1.4 million deaths . Poor treatment compliance – due to the requirement for prolonged multidrug therapy – as well as the use of inadequate regimens has fueled the emergence of multi-drug-resistant and extensively-drug-resistant (MTD-TB and XDR-TB) TB strains. MDR-TB is resistant to at least isoniazid and rifampicin and XDR-TB is resistant to isoniazid, rifampicin, fluoroquinolones and at least one of the injectables .","true","true","0.4875124","2","2","3","Nagoya J Med Sci","TUBERCULOSIS AND RIFAMPICIN RESISTANCE AMONG MIGRANTS IN KYRGYZSTAN: DETECTION BY A NEW DIAGNOSTIC TEST","HAMAJIMA, NOBUYUKI","The global burden of tuberculosis (TB) cases and its drug resistance has been increasing both in developing and developed countries. According to the World Health Organization (WHO), multidrug-resistant tuberculosis (MDR-TB) is defined as tuberculosis which is resistant to isoniazid and rifampicin, with or without resistance to other first-line drugs.) Globally, 3.7% of new cases and 20% of previously-treated cases were estimated to have MDR-TB.","false","false","0.5700285","1","2","4","PLoS Negl Trop Dis","Golgi-Located NTPDase1 of  Leishmania major Is Required for Lipophosphoglycan Elongation and Normal Lesion Development whereas Secreted NTPDase2 Is Dispensable for Virulence","Vasconcelos, Eveline","Leishmania parasites cause a spectrum of diseases in humans, ranging from localized cutaneous lesions to disseminated mucocutaneous and lethal visceral infections. It is estimated that 1.5 to 2 million new cases of leishmaniasis occur annually and that more than 350 million people are at risk worldwide. Current first-line drug treatments are suboptimal due to high toxicity, cost, requirement for hospitalization and/or the emergence of drug-resistant strains, highlighting the need for the development of more effective therapeutics .","false","false","0.30883577","1","4","2","PLoS ONE","Procurement and Supply Management System for MDR-TB in Nigeria: Are the Early Warning Targets for Drug Stock Outs and Over Stock of Drugs Being Achieved?","Escobar-Gutiérrez, Alejandro","Multi-Drug Resistant tuberculosis (MDR-TB, defined as resistance to both isoniazid and rifampicin) [], constitutes a global public health crisis. Nigeria is one of the high MDR-TB burden countries with an MDR-TB prevalence of 2.9% among new TB cases and 14% among patients previously treated for TB []. In 2013, there were an estimated 3700 MDR-TB patients of whom only 669 (18%) were notified and only 426 placed on treatment.","false","true","0.5193797","2","1","1"
"42","SAME_JOURNAL","PLoS ONE","Association of  Matrix Metalloproteinase-9 ( MMP9) Variants with Primary Angle Closure and Primary Angle Closure Glaucoma","Acott, Ted S","Glaucoma is the leading cause of irreversible blindness worldwide, and is characterized by retinal ganglion cell death which results in vision loss []. Primary open-angle glaucoma (POAG) and primary angle closure glaucoma (PACG) are two major forms of glaucoma. PACG is characterized by the apposition between the peripheral iris and trabecular meshwork, which causes elevated intraocular pressure (IOP).","PLoS Genet","Common Genetic Variants near the Brittle Cornea Syndrome Locus  ZNF469 Influence the Blinding Disease Risk Factor Central Corneal Thickness","Gibson, Greg","Glaucoma is one of the leading causes of irreversible blindness worldwide. It is estimated that by 2010, approximately 60.5 million people globally will be affected by this condition . It is characterized by a progressive loss of retinal ganglion cells which will lead to visual field damage. The most common form is open-angle glaucoma (OAG), an adult-onset condition that generally affects people over the age of 40.","false","false","0.45309412","3","2","3","PLoS ONE","Correlation between Systemic Oxidative Stress and Intraocular Pressure Level","Acott, Ted S","Glaucoma, which is characterized by progressive “glaucomatous” optic neuropathy and visual field loss, is a leading cause of irreversible blindness worldwide [,], including Japan []. Retinal ganglion cell (RGC) death resulting from apoptosis and RGC axon loss leads to glaucomatous optic neuropathy, in which elevated intraocular pressure (IOP) is the primary risk factor []. In open-angle glaucoma (OAG) including primary OAG (POAG) and glaucoma secondary to pseudoexfoliation syndrome (EX), the IOP increases as the result of reduced aqueous humor outflow at the trabecular meshwork (TM) [].","true","true","0.6080823","3","1","1","PLoS ONE","A Laser-Induced Mouse Model with Long-Term Intraocular Pressure Elevation","Bui, Bang V.","Glaucoma is a major cause of blindness throughout the world and the second leading cause of irreversible blindness in the USA , . Primary open angle glaucoma (POAG), the most common form of glaucoma, is characterized by a progressive optic neuropathy with loss of retinal ganglion cells (RGC) and optic nerve axons, resulting in impairment of visual function. An elevated intraocular pressure (IOP) is the most important risk factor for most forms of glaucoma including POAG.","false","true","0.62248343","3","3","4","Ophthalmol Eye Dis","Tafluprost for the Reduction of Interocular Pressure in Open Angle Glaucoma and Ocular Hypertension","Schultz, Clyde","Glaucoma is a progressive atrophy of the optic nerve of the eye which will often cause blindness in affected individuals if left untreated. There are two manifestations of glaucoma, primary open angle and closed angle. Primary open angle glaucoma (POG) is the most common form of glaucoma. It is a progressive disease with few overt symptoms, but is often accompanied by increased intraocular pressure (IOP).","false","false","0.5629784","3","4","1"
"43","SAME_JOURNAL","PLoS ONE","USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock","Oster, Henrik","Circadian rhythms are observed in broadly across organisms from bacteria to mammals. These rhythms are generated by an internal time-measuring system, the circadian clock, operating at the cellular level []. Mammalian circadian clockwork is composed of a series of clock genes and protein products forming a transcriptional-translational negative feedback loop []. A heterodimer of CLOCK and BMAL1 binds to E-box cis-elements and activates transcription of their neighboring genes [–].","PLoS ONE","A Novel  Bmal1 Mutant Mouse Reveals Essential Roles of the C-Terminal Domain on Circadian Rhythms","Oster, Henrik","Most living organisms harbor biological timers called circadian clocks to drive daily physiological and behavioral rhythms. In mammals, the molecular circadian clock is composed of interlocked feedback loops. The CLOCK:BMAL1 heterodimer activates the transcription of clock genes such as Periods (Per1/2), Cryptochromes (Cry1/2), Rors and Rev-erbs. The translated PER and CRY proteins subsequently repress the activity of CLOCK:BMAL1.","true","true","0.50058633","1","2","2","PLoS ONE","Regulation of  per and  cry Genes Reveals a Central Role for the D-Box Enhancer in Light-Dependent Gene Expression","Yamazaki, Shin","The circadian clock is a highly conserved, physiological timing mechanism that allows organisms to anticipate and adapt to daily environmental changes . At the core of the vertebrate circadian clock mechanism are interlocking transcription translation feedback loops that are composed of activator and repressor clock proteins . The main loop consists of the positive elements CLOCK and BMAL, which form heterodimers that activate the transcription of the negative elements, period (per) and cryptochrome (cry).","false","true","0.54464793","3","1","3","PLoS Genet","Long-Range Chromosome Interactions Mediated by Cohesin Shape Circadian Gene Expression","Kramer, Achim","Circadian rhythm is a daily oscillation of physiological processes and behaviors in varieties of living systems [,]. In mammals, the endogenous clock is established by interconnected transcriptional-translational feedback loops including a series of clock genes, for instance, Bmal1, Clock, Nr1d1, Nr1d2, Per and Cry family genes [,]. Transcription factor complex Bmal1-Clock drives Nr1d1, Nr1d2, Per and Cry family gene expression via cis-regulatory element E-box.","false","false","0.53096867","3","3","3","PLoS Genet","CLOCKWORK ORANGE Enhances PERIOD Mediated Rhythms in Transcriptional Repression by Antagonizing E-box Binding by CLOCK-CYCLE","Taghert, Paul H.","Almost all organisms from Cyanobacteria to humans have internal circadian clocks that drive daily rhythms in physiology, metabolism and behavior, thereby synchronizing internal processes with the external environment. In eukaryotes, the circadian clock keeps time via one or more transcriptional feedback loops []. In Drosophila, a heterodimer formed by CLOCK (CLK) and CYCLE (CYC) binds E-box sequence activates transcription to initiate clock function.","false","false","0.56067044","2","4","2"
"44","SAME_AUTHOR","PLoS ONE","Human Papillomavirus 16 Infection and  TP53 Mutation: Two Distinct Pathogeneses for Oropharyngeal Squamous Cell Carcinoma in an Eastern Chinese Population","Liu, Xuefeng","Recently, human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) has been recognized as a unique subset of head and neck squamous cell carcinomas (HNSCC). HPV infection has been implicated as a causative factor in OPSCC by the World Health Organization [], with an infection rate varying from 36.5% to 90% in some studies [–], whereas tobacco and alcohol consumption are important pathogenic factors in non HPV-associated OPSCC [–].","PLoS ONE","HIV Protease Inhibitors Sensitize Human Head and Neck Squamous Carcinoma Cells to Radiation by Activating Endoplasmic Reticulum Stress","Alpini, Gianfranco","Human head and neck carcinoma includes a heterogeneous group of malignancies of the oral cavity, oropharynx, hypopharynx, larynx, lips, paranasal sinuses and salivary glands []. More than 90% of these cancers are squamous cell carcinomas (HNSCC). HNSCC represents the sixth most common malignancy worldwide []. The major risk factors include tobacco and alcohol consumption, poor oral hygiene, and infection by human papillomavirus (HPV) [–].","false","true","0.3808323","2","2","1","PLoS ONE","Chronic Inflammation-Related HPV: A Driving Force Speeds Oropharyngeal Carcinogenesis","Liu, Xuefeng","Head and neck squamous cell carcinoma (HNSCC) includes cancers arising from the lining epithelium of the oral cavity, larynx, pharynx, and nasopharynx. High-risk human papilloma virus (HPV) has been recognized as an important risk factor in a subset of oropharyngeal squamous cell carcinomas (OPSCC) and HPV-positive OPSCC has a more favorable prognosis compared to HPV-negative OPSCC[–]. The incidence of HPV-positive OPSCC in the United States enhanced at approximately 7.","true","true","0.6250887","1","2","2","Rambam Maimonides Med J","Transoral Robotic Surgery in the HPV Era","Gil, Ziv","The rate of head and neck squamous cell carcinoma (HNSCC) has been increasing recently secondary to an epidemic of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC).– HPV-positive OPSCC has a unique demographic, risk factor profile, and tumor biology. The incidence of tonsil and base of tongue cancers is approximately 2 per 100,000 with an incidence increase of 3.9% and 2.","false","false","0.5766075","3","2","3","PLoS ONE","Dynamic Contrast-Enhanced MR Imaging Predicts Local Control in Oropharyngeal or Hypopharyngeal Squamous Cell Carcinoma Treated with Chemoradiotherapy","Zhang, Zhuoli","Oropharyngeal and hypopharyngeal squamous cell carcinomas (OHSCC) are common malignant tumors of the head and neck that has long been considered as having similar risk factors and lymphatic drainage. However, human papillomavirus (HPV) is recently recognized to play a role in the pathogenesis of a subset of clinically and molecularly distinct head and neck squamous cell carcinomas (HNSCC), most commonly located in the oropharynx.","false","true","0.48993623","2","3","4"
"45","DIFFERENT_JOURNAL","PLoS ONE","Detection of a Serum Siderophore by LC-MS/MS as a Potential Biomarker of Invasive Aspergillosis","Chotirmall, Sanjay Haresh","Invasive aspergillosis (IA) is a life-threatening infection that affects immunosuppressed individuals including those with neutropenia, chronic granulomatous disease, acquired immune deficiency syndrome, those undergoing hematopoietic stem cell transplantation (HSCT) or solid organ transplantation, especially those with graft-versus-host disease[–]. The causative agent of IA is most commonly Aspergillus fumigatus, although other Aspergillus species such as A.","PLoS Genet","Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis","Bachewich, Catherine","Invasive fungal infections have a devastating impact on human health worldwide. The most vulnerable individuals are those suffering from immune deficiencies due to chemotherapy for cancer, immunosuppression for transplants of solid organs or stem cells, or infection with HIV []. The incidence of deadly invasive fungal infections is on the rise, in concert with the increasing use of immunosuppressive measures and invasive medical procedures [,].","false","false","0.35598335","1","1","3","PLoS ONE","Metabolomic Profiling of Faecal Extracts from  Cryptosporidium parvum Infection in Experimental Mouse Models","Blader, Ira J","Cryptosporidiosis, a gastroenteric disease characterized mainly by diarrheal illnesses in humans and mammals is caused by infection with the protozoan parasite Cryptosporidium. The disease, though mainly self-limiting in those that are immunocompetent, can be chronic and lead to severe dehydration with terminal results in those that are immunocompromised []. Children, particularly those age five years or less are most susceptible to cryptosporidiosis where chronic infections have been shown to impair growth and cognitive development.","false","true","0.30192983","2","3","2","PLoS ONE","A microRNA Encoded by Kaposi Sarcoma-Associated Herpesvirus Promotes B-Cell Expansion  In Vivo","Simas, J. Pedro","Kaposi sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), a tumor of endothelial origin, as well as the lymphoproliferative disorders primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD) –. Like all herpesviruses, KSHV can establish long-term latent infections of its host cell. The natural target cell of KSHV infection in vivo is the B-cell, and latently infected memory B-cells are thought to represent a reservoir that is of importance for the lifelong KSHV persistence.","false","true","0.14569856","3","3","4","PLoS ONE","The  Aspergillus fumigatus pkcAG579R Mutant Is Defective in the Activation of the Cell Wall Integrity Pathway but Is Dispensable for Virulence in a Neutropenic Mouse Infection Model","Yu, Jae-Hyuk","Aspergillus fumigatus is a ubiquitous mold and opportunistic human pathogen that causes a number of clinical diseases including the life-threatening disease, invasive pulmonary aspergillosis (IA). Immunocompromised individuals such as those with prolonged neutropenia, recipients of hematopoietic stem-cell transplants or solid-organ transplants, and patients with advanced acquired immunodeficiency syndrome or chronic granulomatous diseases have a high incidence of IA [].","false","true","0.65002376","4","2","1"
"46","SAME_JOURNAL","PLoS Negl Trop Dis","Evaluation in Cameroon of a Novel, Simplified Methodology to Assist Molecular Microbiological Analysis of  V.  cholerae in Resource-Limited Settings","Ryan, Edward T.","Cholera remains a major public health problem in developing countries, particularly in Africa and Asia, where endemic and epidemic disease continues to devastate vulnerable populations. The etiologic agent of cholera, V. cholerae, has more than 200 serogroups, differentiated by the O-antigen on the lipopolysaccharide (LPS) of the bacteria’s outer membrane []. Of these 200 serogroups, only those that produce cholera toxin (CT) are known to cause epidemic and pandemic disease, primarily serogroups O1 and O139 [].","PLoS Negl Trop Dis","Immunogenicity of a Killed Bivalent (O1 and O139) Whole Cell Oral Cholera Vaccine, Shanchol, in Haiti","Leme, Elizabeth Angelica","Cholera remains a public health problem for many of the world's poorest individuals. Approximately 3 million cases of diarrheal illness and 120,000 deaths are caused by V. cholerae annually . Devastating epidemics occur when V. cholerae is introduced into an immunologically naive population that lacks access to safe water and sanitation. This occurred when a pandemic V. cholerae O1 strain was introduced into Haiti in 2010 , , resulting in 693,088 cases and 8474 reported deaths as of November 27, 2013 .","false","true","0.37285066","1","2","4","PLoS Negl Trop Dis","The Population Structure of  Vibrio cholerae from the Chandigarh Region of Northern India","Baker, Stephen","Cholera, caused by the Gram-negative bacterium Vibrio cholerae, is classically associated with rapidly dehydrating watery diarrhoea. Although more than 200 serogroups of V. cholerae have been identified; only the O1 and O139 serogroups are associated with epidemic and pandemic outbreaks. Historically, seven pandemics of cholera have been recognised with so called ‘classical’ strains associated with the first six and ‘El Tor’ stains with the seventh pandemic.","false","true","0.45014068","3","2","1","PLoS ONE","Comparative Genomic Characterization of a Thailand–Myanmar Isolate, MS6, of  Vibrio cholerae O1 El Tor, Which Is Phylogenetically Related to a “US Gulf Coast” Clone","Dutilh, Bas E.","Vibrio cholerae, which is present in aquatic environments worldwide, is a facultatively anaerobic, asporogenous, motile, curved, or straight gram-negative rod. There are more than 200 serogroups of V. cholerae, but only serogroups O1 and O139 cause epidemics and pandemics of cholera in human populations , and cholera toxin causes the major clinical signs of the disease. The O1 serogroup is classified into classical or El Tor biotypes.","false","false","0.6041585","4","2","2","PLoS Negl Trop Dis","Use of a Cholera Rapid Diagnostic Test during a Mass Vaccination Campaign in Response to an Epidemic in Guinea, 2012","Ryan, Edward T.","Cholera is an acute diarrhoeal infection caused by ingestion of the bacterium Vibrio cholerae. Two serogroups– O1 and O139 – are responsible for cholera epidemics. While V. cholerae O1 causes the majority of outbreaks over the world, O139 – first identified in Bangladesh in 1992 – is confined to South-East Asia , where its incidence has declined over the years . Globally, O139 accounts for a small minority of cholera cases , and local transmission has never been reported in Africa or America.","true","true","0.46547467","1","2","3"
"47","SAME_JOURNAL","PLoS ONE","Prognostic Impact of Time to Ipsilateral Breast Tumor Recurrence after Breast Conserving Surgery","Chu, Pei-Yi","The oncological outcome (overall survival, distant metastasis, contralateral breast cancer rates) of breast-conserving surgery (BCS) combined with adjuvant radiotherapy is equivalent to mastectomy in the treatment of the early-stage breast cancer [–]. The incidence of ipsilateral breast tumor recurrence (IBTR) following BCS is estimated from 5 to 10% in studies with 10 years follow up from the initial tumor treatment [,,–].","PLoS Comput. Biol","Improving Breast Cancer Survival Analysis through Competition-Based Multidimensional Modeling","Bonneau, Richard","Breast cancer remains the most common malignancy in females, with more than 200,000 cases of invasive breast cancer diagnosed in the United States annually . Molecular profiling research in the last decade has revealed breast cancer to be a heterogeneous disease –, motivating the development of molecular classifiers of breast cancer sub-types to influence diagnosis, prognosis, and treatment.In 2002, a research study reported a molecular predictor of breast cancer survival  based on analysis of gene expression profiles from 295 breast cancer patients with 5 year clinical follow-up.","false","false","0.45963857","4","3","1","PLoS ONE","Epigenomic Alterations in Breast Carcinoma from Primary Tumor to Locoregional Recurrences","Tost, Jorg","Breast conservative therapy, consisting in a partial mastectomy followed by whole breast irradiation, is the standard treatment for patients with early stage breast cancer. Overall survival is not significantly different from more physically and psychologically aggressive treatments such as mastectomy . However, patients relapse within 10 years in the same breast as the primary tumor (PT) in approximately 6  of cases , and within 5 years in the contralateral breast in approximately  of cases  or more in BRCA1/2 mutation carriers .","false","true","0.56293994","2","4","4","PLoS Genet","The Circadian Rhythm Gene  Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer","Barsh, Gregory S.","Breast cancer is the most common form of malignancy in women and is the second leading cause of cancer-related death for women in the United States []. Mortality for breast cancer, like most solid cancers, is due not to the primary tumor but instead to metastases, the secondary tumors that arise in distant anatomical sites from cells that have disseminated from the original tumor mass. If the tumor remains localized, the five-year survival rate for breast cancer approaches 99%, suggesting that current clinical interventions for localized breast cancer are highly effective.","false","false","0.468935","3","2","3","PLoS ONE","Rapid Discrimination of Malignant Breast Lesions from Normal Tissues Utilizing Raman Spectroscopy System: A Systematic Review and Meta-Analysis of In Vitro Studies","Chu, Pei-Yi","Breast cancer is the most prevalent cancer among women worldwide, with an estimated 1.7 million cases and 521,900 deaths in 2012 []. The first-line treatment of breast cancer involves breast conserving surgery (BCS) or mastectomy. With the advantages of minimizing volume deficit and maximizing aesthetics, BCS could earn the same long-term survival as mastectomy if tumor-free margin is achieved and followed with radiation to the breast [].","true","true","0.54291254","1","1","2"
"48","SAME_JOURNAL","PLoS ONE","Application of a Persistent Heparin Treatment Inhibits the Malignant Potential of Oral Squamous Carcinoma Cells Induced by Tumor Cell-Derived Exosomes","Tang, Chih-Hsin","Oral cancer accounts for 2%–3% of all human malignancies and is trending upward yearly []. Regardless of recent advancements in many therapeutic strategies, oral cancer remains associated with recurrence and deterioration. Oral squamous cell carcinoma (OSCC) accounts for approximately 90% of cancer types. Thus, the performance of treatments for oral cancer needs to be improved.Exosomes, which are small membrane vesicles that originate from multi-vesicular bodies, 30–100 nm in diameter, are released by a variety of mammalian cells into the extracellular space and are taken up by recipient cells [, ].","PLoS ONE","Identification of Host-Immune Response Protein Candidates in the Sera of Human Oral Squamous Cell Carcinoma Patients","Wei, Qing-Yi","Oral cancer represents the sixth most prevalent cancer in the world. Among the different types of oral cancer, oral squamous cell carcinoma (OSCC) arising from the oral mucosa accounts for more than 90% of these malignancies. Thus, OSCC is the most common malignancy affecting the head and neck region. Notably, there are nearly 300,000 new cases of oral cancer reported annually , , and it was estimated that approximately 128,000 oral cancer patients died worldwide in 2008 .","false","true","0.58693916","3","4","1","Indian J Med Paediatr Oncol","Clinical evaluation of total and lipid bound sialic acid levels in oral precancer and oral cancer","Taqi, Syed Ahmed","Squamous cell carcinoma is the most common cancer in the oral cavity. There are 222,000 new cases (5% of all cancers) of oral cancer diagnosed in men each year globally and 90,000 new cases (2% of all cancers) diagnosed in women. The 5-year survival rate is estimated to be about 50%.[] In India, oral cancer ranks number one among all cancers in male patients and number three among cancers in female patients.","false","false","0.45329583","3","1","3","PeerJ","A genetic programming approach to oral cancer prognosis","Nakai, Kenta","Oral cancer, commonly known as mouth cancer, is the abnormal growth of cells found in the different regions of the mouth including the tongue, floor of the mouth, buccal mucosa (cheeks), and lips (). According to the Oral Cancer Research and Coordinating Centre (OCRCC) in the University of Malaya, there are 350,000 new cases of oral cancer reported worldwide every year, bringing oral cancer to the rank of the 6th most common cancer in the world.","false","false","0.45026794","2","3","4","PLoS ONE","[named-content: null] Attenuates Metastasis via Akt Pathways in Oral Cancer Cells","Tang, Chih-Hsin","Head and neck squamous-cell carcinoma accounts for approximately 3% of all cancers in the United States, and oral squamous-cell carcinoma (OSCC) is the most common form of head and neck cancer []. The high rate of metastasis to cervical lymph nodes causes the poor survival rate of oral cancer []. Cancer cells typically spread by secreting various molecules that degrade the extracellular matrix (ECM), invading the blood vessels, and migrating to distant organs [].","true","true","0.49852157","3","2","2"
"49","SAME_JOURNAL","PLoS ONE","From Bench to Bedside: Attempt to Evaluate Repositioning of Drugs in the Treatment of Metastatic Small Cell Lung Cancer (SCLC)","Minna, John D","Lung cancer is the most frequently diagnosed malignancy worldwide and is a leading cause of cancer mortality []. Importantly, Hungarians have the world’s highest death rates from lung cancer [].Small cell lung cancer (SCLC) is a very aggressive neuroendocrine subtype, and accounts for 15% [] of all lung cancers. While the number of new agents and treatment options has markedly increased in other cancers, for SCLC, chemotherapy remains the main component of care and no new class of systemic therapy has entered clinical practice in the past three decades [].","PLoS ONE","Low Prognostic Nutritional Index Correlates with Worse Survival in Patients with Advanced NSCLC following EGFR-TKIs","Minna, John D","Lung cancer remains the leading cause of cancer-related mortality []. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers []. Compared with chemotherapy, molecular-targeted therapies, such as epidermal growth factor receptor (EGFR) inhibitors, have recently gained great attention for their potential to improve survival and quality of life with acceptable side effects [–] The presence of sensitive EGFR mutations is regarded as not only a predictive but also prognostic factor for the efficacy of EGFR-TKIs [–].","true","true","0.48215804","1","3","1","Medicine (Baltimore)","Chinese Herbal Medicine for Improving Quality of Life Among Nonsmall Cell Lung Cancer Patients","Wang., Wei","Lung cancer is 1 of the most prevalent cancers worldwide for decades. It is, respectively, the first and third most common cancer in male and female. Lung cancer is estimated to contribute to nearly one-fifth of deaths globally. While the incidence of lung cancer has declined in some regions of the world, but it is increasing quickly in China. Small cell lung cancer and nonsmall cell lung cancer (NSCLC) are the 2 major types, and it is reported that the latter accounts for 85% to 90% of all global lung cancer cases.","false","false","0.67200005","2","3","3","PLoS ONE","Gambogenic Acid Kills Lung Cancer Cells through Aberrant Autophagy","Asselin, Eric","Lung cancer has been one of the most common types of cancer for several decades and accounts for 15–20% of all cancer-related deaths globally –. By 2008, an estimated 1.61 million new cases per year were reported worldwide. Lung cancer is a major cause of death in the developed world and the most common cancer in China . Surgical resection is the primary method of treatment for lung cancer. However, chemotherapy/radiation therapy is still the effective treatment for patients with advanced non-small cell lung cancer (NSCLC) or small cell lung cancer .","false","true","0.69376767","1","1","2","Tuberc Respir Dis (Seoul)","Year-in-Review of Lung Cancer","Son, Ji Woong","Lung cancer is the leading cause of cancer-related mortality in the developed world, accounting for 26~29% of all cancer deaths. Non-small cell lung cancer (NSCLC) accounts for 80% of all lung cancer diagnosis and the majority (60~80%) of patients are diagnosed at an advanced stage. Consequently, the prognosis for NSCLC remains poor, with a 5-year survival rate of 15%.The histologic subtype of lung cancer has had little impact on the selection of therapy.","false","false","0.6608155","2","2","4"
"50","DIFFERENT_JOURNAL","PLoS ONE","Efficient and Specific Analysis of Red Blood Cell Glycerophospholipid Fatty Acid Composition","Oresic, Matej","The supply of n-3 long chain polyunsaturated fatty acids (LC-PUFA) is related to cardiovascular function, heart disease, morbidity and mortality, and in the perinatal period to child development , . Commonly used biological markers for the dietary n-3 fatty acid intake are fatty acid composition of plasma or serum phospholipids (PL), triacylglycerides (TAG), cholesterol esters (CE), phosphatidylcholine (PC) and of red blood cell (RBC) PL, PC and phosphatidylethanolamine (PE) , .","PLoS ONE","Differential Effects of Dietary Oils on Emotional and Cognitive Behaviors","Young, Scott","It has long been known that dietary fatty acids improve some limbic and cortical functions in humans. Ketogenic diets use long-chain fatty acids (LCFAs, ≥ 16 carbon atoms) including palmitic acid and stearic acid and/or medium-chain triglycerides (MCTs, 8–14 carbon atoms) to improve seizures in patients with intractable epilepsy [,]. Clinical trials have shown that n-3 polyunsaturated fatty acids, especially eicosapentaenoic acid (EPA), can reduce depression [].","false","true","0.4475963","1","2","4","PLoS ONE","Serum Liver Fatty Acid Binding Protein Levels Correlate Positively with Obesity and Insulin Resistance in Chinese Young Adults","Xu, Haiyan","The fatty-acid-binding proteins (FABPs) are a family of low-molecular-weight intracellular lipid-binding proteins involved in the regulation of lipid metabolism and inflammation . Cytosolic FABPs provide solubility and intracellular trafficking of long-chain fatty acids and other hydrophobic ligands , which are most active in long chain fatty acid (LCFA) uptake and metabolism (liver, intestine), oxidation (kidney, heart, skeletal muscle) and storage (adipose) , .","false","true","0.3048029","2","2","3","PLoS ONE","Virulence of  Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of  katG Mutants and the Possible Role of AhpC","Karakousis, Petros C.","Tuberculosis (TB) has killed more people than any other infectious disease in history. In the last century, the number of deaths due to TB has declined due to the discovery of anti-TB chemotherapy, but HIV coinfection as well as the increasing number of drug resistant cases has worsened the global burden of the disease []. Isoniazid (INH) is one of the most effective drugs within a multi-drug regimen to treat patients with active TB.","false","true","0.025850065","2","4","2","PLoS ONE","Eicosapentaenoic Acid and Docosahexaenoic Acid in Whole Blood Are Differentially and Sex-Specifically Associated with Cardiometabolic Risk Markers in 8–11-Year-Old Danish Children","Desseyn, Jean-Luc","Intake of n-3 long-chain polyunsaturated fatty acids (LCPUFA) from fish and fish oils have been shown to improve cardiovascular risk markers in adults, most pronouncedly plasma triacylglycerol and blood pressure, and may also reduce coronary heart disease mortality , although not all meta analyses agree . The metabolic syndrome (MetS) is defined as a cluster of cardiovascular risk factors including abdominal obesity, dyslipidemia, glucose intolerance, and hypertension .","false","true","0.33241883","2","1","1"
"51","SAME_JOURNAL","PLoS ONE","Prevalence of High-Risk Human Papillomavirus (HR-HPV) Genotypes and Multiple Infections in Cervical Abnormalities from Northern Xinjiang, China","Tornesello, Maria Lina","Cervical cancer is the second most common malignancy among women and the leading cause of cancer-related death among females worldwide [, ]. Epidemiological studies have shown that human papillomavirus (HPV) is the main cause of cervical cancer and precancerous lesions []. To date, over 100 HPV genotypes have been identified [], and research studies have revealed that the pathogenicity of various strains of HPV is significantly different from each other [].","PLoS ONE","Association of Long Non-Coding RNA HOTAIR Polymorphisms with Cervical Cancer Risk in a Chinese Population","Yang, Ming","Worldwide, cervical cancer is the second most-common cancer and fourth most frequent cause of death from cancer among females. It was estimated that there were approximately 528,000 new cases and 266,000 deaths in 2012. Epidemiology studies have demonstrated that high-risk human papillomaviruses (HPVs), smoking habit, hormone replacement therapy use and genetic factors have been implicated in the pathogenesis of cervical cancer[].","false","true","0.598146","1","1","2","Medicine (Baltimore)","A Functional Polymorphism in the Promoter of MiR-143/145 Is Associated With the Risk of Cervical Squamous Cell Carcinoma in Chinese Women","Jimmy, Efird.","Cervical cancer, arising from the cervix, is the fourth most common cancer among women. In 2012, it accounted for about 528,000 cases and 266,000 deaths worldwide, and 80% of the cases occurred in developing countries., Epidemiologic studies have identified that human papillomavirus (HPV) infection is involved in the development of cervical cancer; some HPV-infected individuals, however, do not develop the disease, indicating that HPV infection is a prerequisite but insufficient cause of cervical cancer.","false","false","0.5561985","1","2","1","PLoS ONE","Association Study between Cervical Lesions and Single or Multiple Vaccine-Target and Non-Vaccine Target Human Papillomavirus (HPV) Types in Women from Northeastern Brazil","Tornesello, Maria Lina","Clinical and epidemiological studies report that cervical infection with High Risk Human papillomavirus (HR HPV) is necessary but not sufficient to cause the development of cervical cancer [,]. Additional risk factors are likely to be involved in the development of cervical cancer, including multiple HPV infections [].Persistent infection with HR HPV is considered as the main cause of cervical lesions and cervical cancer [].","true","true","0.479621","3","3","3","PLoS Pathog","A  Drosophila Model of HPV E6-Induced Malignancy Reveals Essential Roles for Magi and the Insulin Receptor","Meyers, Craig","Cervical cancer is the fourth leading cause of cancer death in women worldwide with ~500,000 new cases of cervical cancer annually and ~250,000 deaths worldwide. The main causative agents of cervical cancer are the high-risk human papillomaviruses (HPVs). HPVs can induce hyperproliferative lesions in epithelia and are responsible for >90% of cervical and anal cancer, and more than 50% of vaginal, vulvar, penile and oropharyngeal cancers as well as a significant number of head and neck squamous cell carcinomas [–].","false","false","0.5037454","3","4","3"
"52","SAME_JOURNAL","PLoS ONE","Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage","Guillou, Hervé","Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are two of the leading causes of liver disease in the United States today. Both ALD and NAFLD are characterized by progressive hepatocellular damage manifested in increased steatosis, steatohepatitis, fibrosis and ultimately progression to cirrhosis []. In the western world, the prevalence of diet-induced nonalcoholic steatohepatitis (NASH) has dramatically increased in the last decade.","PLoS ONE","Activation of Kupffer Cells Is Associated with a Specific Dysbiosis Induced by Fructose or High Fat Diet in Mice","Guillou, Hervé","Non alcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance, diabetes, hypertriglyceridemia and arterial hypertension in the metabolic syndrome []. With the increasing incidence of obesity, NAFLD becomes probably the most common cause of chronic liver disease in Western countries. NAFLD can progress from steatosis to steatohepatitis (NASH, non-alcoholic steatohepatitis), fibrosis, cirrhosis and hepatocellular carcinoma [].","true","true","0.6071767","2","1","2","PeerJ","Alcohol consumption and risk of fatty liver disease: a meta-analysis","Patton, Bob","Fatty liver disease (FLD) is caused by the excessive accumulation of fat in the liver cells () which encompasses a morphological spectrum consisting of hepatic steatosis (fatty liver) and steatohepatitis that can progress to cirrhosis and hepatocellular carcinoma (). FLD is commonly divided into alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) ().ALD is a liver injury as a consequence of excessive or harmful alcohol use, which includes a spectrum of injury, ranging from simple steatosis to cirrhosis (; ).","false","false","0.5709114","2","2","2","PLoS ONE","Establishment of a General NAFLD Scoring System for Rodent Models and Comparison to Human Liver Pathology","Sookoian, Silvia C.","Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in developed countries, paralleling the increased prevalence of obesity during the last decades –. NAFLD encompasses a wide spectrum of liver pathology ranging from non-alcoholic hepatic steatosis to steatohepatitis (NASH), that can evolve into liver fibrosis, cirrhosis and its life threatening complications or hepatocellular cancer .","false","true","0.6132857","3","3","2","PLoS ONE","Performance of Transient Elastography for the Staging of Liver Fibrosis in Patients with Chronic Hepatitis B: A Meta-Analysis","Fung, James","Liver fibrosis occurs in response to almost all causes of chronic liver insult, and its initiation is an important phase of chronic liver disease.  Without appropriate intervention, liver fibrosis progresses, leading to changes in liver morphology and deterioration of liver function and hemodynamics. Eventually, progression of liver fibrosis increases the risk for hepatocellular carcinoma (HCC) and hepatic decompensation, which are serious complications in patients with end-stage liver disease.","false","true","0.4621248","3","3","3"
"53","SAME_JOURNAL","PLoS ONE","Increased Circulating Levels of Alpha-Ketoglutarate in Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease","Strnad, Pavel","Obesity is an important risk factor associated with the metabolic alterations of such diseases as diabetes mellitus type 2, insulin resistance, hyperlipidemia, and non-alcoholic fatty liver disease (NAFLD) []. Although obesity is an important risk factor, not all patients with NAFLD are obese []. NAFLD has become the most common liver disorder in the developed countries, affecting over one-third of the population [,].","Medicine (Baltimore)","The Presence of White Matter Lesions Is Associated With the Fibrosis Severity of Nonalcoholic Fatty Liver Disease","Volti., Giovanni Li","The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide in parallel to the growing pandemic of overweight and obesity. This picture accounts for NAFLD as the most common cause of chronic liver disease, as a dramatically growing risk factor of hepatocellular carcinoma, and as an indication for liver transplantation. Long-term prospective studies looking at the natural history of NAFLD showed that, although patients with fatty liver accumulation are at high risk of liver-related mortality, cardiovascular events remain the most common cause of death.","false","false","0.4999219","2","3","3","PLoS ONE","Kupffer Cells Undergo Fundamental Changes during the Development of Experimental NASH and Are Critical in Initiating Liver Damage and Inflammation","Strnad, Pavel","Non-alcoholic fatty liver disease (NAFLD) has emerged as the leading liver disease in North America[]. Considered the hepatic manifestation of obesity, NAFLD includes a spectrum of liver diseases including the progressive inflammatory disease non-alcoholic steatohepatitis (NASH). Numerous studies have been carried out to understand the role of both resident and recruited immune cells contributing to the progression of NASH.","true","true","0.4094673","3","4","1","PLoS ONE","Association of Liver Enzymes and Computed Tomography Markers of Liver Steatosis with Familial Longevity","Vinciguerra, Manlio","Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries and is associated with metabolic risk factors such as obesity, diabetes mellitus, and dyslipedimia . NAFLD is prevalent in more than one-third of the elderly , while prevalence may increase up to 69% in type 2 diabetes patients .Hepatocyte dysfunction due to liver fat accumulation may interfere with insulin action and cause hepatic insulin resistance .","false","true","0.6179144","3","2","2","Medicine (Baltimore)","Nonalcoholic Fatty Liver Disease as a Risk Factor of Arterial Stiffness Measured by the Cardioankle Vascular Index","Tarantino., Giovanni","Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease with an estimated prevalence of 20% to 30% in the West and 16% to 33% in Korea.– Because the development of NAFLD has been linked to insulin resistance and metabolic syndrome,– NAFLD is closely associated with obesity, dyslipidemia, type II diabetes, and cardiovascular disease.– Evidences suggest that the severity of NAFLD is associated with the extent of increased cardiovascular risk, independent of conventional risk factors.","false","false","0.6071412","1","1","4"
"54","SAME_JOURNAL","PLoS ONE","The Diagnostic Accuracy and Clinical Utility of Three Noninvasive Models for Predicting Liver Fibrosis in Patients with HBV Infection","Kim, Seung Up","Hepatitis B virus (HBV) infection affects 350 million individuals and there are almost one million people died for HBV-related liver diseases every year[]. Liver biopsy is still the gold standard for assessing hepatic fibrosis in patients with HBV infection. However, liver biopsy is limited by invasiveness and susceptibility of this technique to sampling error[,]. Magnetic Resonance Imaging (MRI), Computed Tomography (CT),and transient elastography(TE) have a better diagnostic value in detecting of hepatic fibrosis.","Medicine (Baltimore)","CONSORT: Effects of adding adefovirdipivoxil to peginterferon alfa-2a at different time points on HBeAg-positivepatients","Zhou., Wen","Hepatitis B virus (HBV) infection is a major public health problem. More than 350 million people are chronically infected with HBV throughout the world.[] Patients with HBV infection are at risk of progressing to long-term complications, including cirrhosis of the liver, decompensated liver disease, and/or hepatocellular carcinoma (HCC). Approximately 93 million people are chronic HBV (CHB) carriers in China, and 300,000 individuals die from chronic disease every year.","false","false","0.5000354","3","2","2","PLoS ONE","Comparison of the Efficacies and Safety of Combined Therapy between Telbivudine Plus Adefovir and Lamivudine Plus Adefovir in Patients with Hepatitis B Virus Infection in Real-World Practice","Kim, Seung Up","Chronic hepatitis B virus (HBV) infection remains a major cause of liver-related morbidity and mortality world as well as more than 350 million chronic infections [,]. High levels of HBV DNA and detectable hepatitis B e antigen (HBeAg) are risk factors for progression to end-stage complications such as decompensated cirrhosis and hepatocellular carcinoma (HCC) [, ]. Treatment of hepatitis B with nucleoside/nucleotide analogues (NUCs) has been shown to reverse fibrosis and cirrhosis and reduce the risk of hepatic decompensation and HCC [, ].","true","true","0.41197374","2","3","1","PLoS ONE","The Efficacy and Safety of Entecavir and Interferon Combination Therapy for Chronic Hepatitis B Virus Infection: A Meta-Analysis","Liu, Chen-Hua","Liver disease associated with persistent hepatitis B virus (HBV) infection represents a major health problem with global impact. Approximately 2 billion people have been infected with HBV at one point, and over 350 million people suffer from chronic hepatitis B (CHB) worldwide []. The progression of HBV-related liver disease to cirrhosis, liver failure and hepatocellular carcinoma (HCC) is estimated to result in 0.","false","true","0.5303695","3","1","3","PLoS Pathog","Combination of DNA Prime – Adenovirus Boost Immunization with Entecavir Elicits Sustained Control of Chronic Hepatitis B in the Woodchuck Model","Walker, Christopher M.","Chronic hepatitis B virus (HBV) infection is still one of the major public health problems. Two billion people worldwide have been infected with HBV, of whom more than 360 million have developed chronic infection. Approximately one million patients die from HBV-associated liver diseases such as cirrhosis and hepatocellular carcinoma (HCC) every year.Over the past 10 years, the treatment options of chronic HBV infection have improved greatly.","false","false","0.48171902","1","4","4"
"55","SAME_AUTHOR","Medicine (Baltimore)","Relationship between serum uric acid and metastatic and nonmetastatic rectal cancer patients with undergoing no chemotherapy","Kapritsou., Maria","Colorectal cancer is the third most common noncutaneous malignancy, and accounts for the second most frequent cause in cancer-related deaths.[] Oncologists have been aware that, compared with colon tumor, the diagnosis, staging and, treatment for rectal cancer have significant difference. Fortunately, local control and survival rate in colorectal cancer has been significantly improved with the improvement of operation and chemotherapy.","Medicine (Baltimore)","Diagnostic accuracy of 18F-FDG PET/CT for detecting synchronous advanced colorectal neoplasia in patients with gastric cancer","Yang., Feng","Gastric cancer is the fifth common form of cancer and the third leading cause of cancer-related deaths worldwide.[] Increased incidence of early gastric cancer and advances in cancer treatment, including surgical skills and adjuvant and neoadjuvant therapy, have improved the survival rate of patients with gastric cancer. Patients with gastric cancer have a risk of developing second primary cancer, and colorectal carcinoma (CRC) is the most common neoplasm associated with gastric cancer.","false","true","0.56282115","1","3","2","Medicine (Baltimore)","Differential MIR-21 Expression in Plasma From Mesenteric Versus Peripheral Veins","Kapritsou., Maria","Colorectal cancer (CRC) is the third most common type of cancer and the second cause of cancer death worldwide. The main prognostic factor for relapse and survival in CRC is disease stage, and patients with stage III disease have a higher risk of relapse than those with stage II. Surgery is the standard treatment for stage I to III, and adjuvant treatment has been shown to be effective in stage III but less so in stage II.","true","true","0.42449978","4","1","3","Ups. J. Med. Sci","Multidisciplinary treatment of patients with rectal cancer: Development during the past decades and plans for the future","Glimelius, Bengt","Colorectal cancer is the third most common cancer worldwide and the second or third most common cause of cancer death. One-third of the cancers arise in the rectum, the rest in the colon, and virtually all cases are adenocarcinomas. Survival has traditionally been less favourable in rectal than in colon cancer, but this has recently changed. The most likely reasons for the presently slightly better 5-year survival rate in rectal cancer () are the efforts to decrease rectal cancer local recurrence rates by better staging, improved surgery, and incorporation of radiotherapy.","false","false","0.64623576","2","2","1","Medicine (Baltimore)","Factors Associated With Oncologic Outcomes Following Abdominoperineal or Intersphincteric Resection in Patients Treated With Preoperative Chemoradiotherapy","Amornyotin., Somchai","Rectal cancer accounts for approximately 30% of colorectal cancers and is a leading cause of cancer death worldwide. The introduction of total mesorectal excision (TME) and preoperative chemoradiotherapy (CRT) has dramatically decreased the local recurrence rates and improved survival in rectal cancer patients. However, these improvements have been relatively modest for patients with very low rectal cancer, compared with those with mid-to-upper rectal cancer.","false","true","0.5840122","3","3","4"
"56","DIFFERENT_JOURNAL","PLoS Genet","Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci","Shi, Jianxin","There are strong epidemiological associations between disrupted circadian rhythms, sleep duration and disease. A circadian rhythm refers to an underlying 24-hour physiological cycle that occurs in most living organisms. In humans, there are clear daily cyclical patterns in core body temperature, hormonal and most other biological systems []. These cycles are important for many molecular and behavioural processes.","PLoS ONE","HnRNP Q Has a Suppressive Role in the Translation of Mouse Cryptochrome1","Foulkes, Nicholas S","Most living creatures from cyanobacteria to humans have daily physiological and behavioral rhythms. The formation of these 24-hour rhythms, called ""circadian rhythms"", is based on the rotation of the earth over a nearly 24-hour period. Although the light-dark cycle resulting from the earth's spin is definitely responsible for synchronizing and entraining the circadian physiologies of living organisms, this circadian rhythm can be maintained in constant darkness for a while, due to the endogenous circadian clock system [].","false","false","0.47660437","2","3","1","PLoS ONE","Isotope Label-Aided Mass Spectrometry Reveals the Influence of Environmental Factors on Metabolism in Single Eggs of Fruit Fly","Nitabach, Michael N.","Circadian clock helps biological organisms to control their physiological and developmental processes . Biological rhythmicity is common in nature, with environmental factors – such as light and temperature – synchronizing internal time of the organisms to the 24-h cycle . Disruption of circadian rhythms can also lead to metabolic disorders . Thus, studying relationships between circadian rhythms and metabolism may contribute to a better understanding of the mechanism and robustness of the biological clock.","false","false","0.4014139","2","2","3","PLoS ONE","Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells","Ouellette, Michel M","Colorectal cancer (CRC) is the third most common malignancy and fourth most common cause of cancer deaths worldwide, with an estimated 1.23 million new cases of CRC diagnosed and a mortality of 608000 in 2008. It is the third most common cancer in men and the second in women worldwide [–]. In Malaysia, CRC is the second most common cancer related mortality after breast cancer based on the Malaysia Cancer Statistics 2006 [].","false","false","0.10520853","2","1","2","PLoS ONE","Assembly of a Comprehensive Regulatory Network for the Mammalian Circadian Clock: A Bioinformatics Approach","Cermakian, Nicolas","Almost all organisms evolved an endogenous circadian clock which regulates the timing of central biological processes and provides a way to adapt physiology and behaviour to daily dark/light rhythms [–]. In mammals, malfunctions of the circadian system are associated to known pathologies ranging from sleep or metabolic disorders, to cancer [–]. Hence, a detailed overview of the underlying genetic network that shapes the mammalian circadian system is of major interest to the circadian and medical field.","false","false","0.375","2","2","4"
"57","SAME_AUTHOR","PLoS ONE","Geranylated 4-Phenylcoumarins Exhibit Anticancer Effects against Human Prostate Cancer Cells through Caspase-Independent Mechanism","Ulasov, Ilya","Prostate cancer is the most common cancer as well as the second leading cause of cancer-related deaths in men []. Despite the availability of multiple treatment options, there are currently no effective therapies available for treatment of apoptotic-resistant androgen-independent prostate cancer which often arises after hormonal deprivation or ablation therapy []. Natural phytocompounds are considered as an important source of cancer chemopreventive and chemotherapeutic agents.","PLoS ONE","Identification of Prostate-Specific G-Protein Coupled Receptor as a Tumor Antigen Recognized by CD8+ T Cells for Cancer Immunotherapy","Hoque, Mohammad O.","Prostate cancer has become the most common cancer among men in the US and is the second leading cause of death from cancer in American men . The standard of care for most patients with prostate cancer is surgery and/or radiation therapy. However, disease recurrence after surgery or radiation still takes place in up to 30% of patients. Although androgen-deprivation therapy is an effective treatment against recurrent disease, most of these patients eventually develop androgen-refractory prostate cancer, which is insensitive to traditional treatment.","false","true","0.5988174","2","2","2","PLoS ONE","Androgen Receptor Promotes Ligand-Independent Prostate Cancer Progression through c-Myc Upregulation","Kyprianou, Natasha","Prostate cancer is the most common cancer in men in the United States with 241,740 new cases anticipated this year . Despite screening and early treatment, prostate cancer commonly recurs, and 28,170 men are predicted to die from prostate cancer this year . Nearly all of these prostate cancer deaths are attributable to metastatic, castration-resistant prostate cancer (CRPC) that has progressed despite androgen deprivation therapy (ADT) – the most common treatment for patients with recurrent or advanced prostate cancer.","false","true","0.6386067","1","2","1","Medicine (Baltimore)","Bisphosphonates in the Treatment of Patients With Metastatic Breast, Lung, and Prostate Cancer","Wang., Hsueh","Lung cancer, breast cancer, and prostate cancer remain the leading cause for cancer mortality worldwide. Lung cancer has an incidence in Europe of 417,000 new cases per year, and a mortality/incidence ratio of 0.88. Breast cancer is the most common cancer type in women worldwide and is the main cause of cancer mortality in women in the world. Prostate cancer is the most common cancer in men in many western countries, and the second leading cause of cancer death in men.","false","false","0.5963257","3","4","2","PLoS ONE","Arg-Gly-Asp (RGD)-Modified E1A/E1B Double Mutant Adenovirus Enhances Antitumor Activity in Prostate Cancer Cells  In Vitro and in Mice","Ulasov, Ilya","Prostate cancer is the most commonly occurring malignancy in the world, especially in Western countries. It is estimated that prostate cancer will cause 220,800 new cases and 27,540 cancer-related deaths in the US in 2015.[] In China, prostate cancer incidence has been rapidly increasing in the past decades, and more than 70% of prostate cancer patients have advanced or metastatic disease.[] To date, hormone therapy is still the most useful therapy for patients with prostate cancer, but it is administered for a limited a period of time and almost all prostate cancer patients who receive androgen ablation ultimately progress to androgen refractory disease,[] known as castration-resistant prostate cancer (CRPC).","true","true","0.5719741","2","3","3"
"58","SAME_AUTHOR","PLoS ONE","Role of Gonadotropin Regulated Testicular RNA Helicase (GRTH/DDX25) on Polysomal Associated mRNAs in Mouse Testis","Wu, Qiang","The testis contains diverse cell populations including somatic Leydig/ Sertoli cells and germ cells (undifferentiated diploid spermatogonia, meiotic spermatocyte, haploid spermatid and spermatozoa). Leydig cells present in the interstitial cells compartment adjacent to the seminiferous tubules contain the steroidogenic enzymes and steroid precursors to produce androgens that are essential for germ cells development.","PLoS Genet","Positive Feedback of  NDT80 Expression Ensures Irreversible Meiotic Commitment in Budding Yeast","Lichten, Michael","During gametogenesis, cells integrate external signals with internal cell-cycle control mechanisms to initiate and sustain meiosis, and eventually to differentiate into gametes. Although the external signals that initiate the switch into meiosis in various organisms are quite diverse, many of the features of meiosis are universal in the production of haploid meiotic products from a diploid progenitor cell , .","false","false","0.32854122","3","2","4","PLoS ONE","Transforming Growth Factor-β1 (TGF-β1) Regulates Cell Junction Restructuring via Smad-Mediated Repression and Clathrin-Mediated Endocytosis of Nectin-like Molecule 2 (Necl-2)","Tsilibary, Effie C.","During spermatogenesis, developing germ cells must migrate from the basal to the adluminal compartment, which requires the disassembly and reassembly of cell junctions between Sertoli cells and developing germ cells . This not only allows progressive movement of developing germ cells along the seminiferous epithelium, but also reattachment of germ cells to adjacent Sertoli cells via cell junctions provides physical support for germ cells.","false","true","0.6743418","4","1","3","PLoS ONE","GPR30, the Non-Classical Membrane G Protein Related Estrogen Receptor, Is Overexpressed in Human Seminoma and Promotes Seminoma Cell Proliferation","Migliaccio, Antimo","Testicular germ cell cancer is the most frequent cancer occurring in young men and originates from transformed gonocytes or undifferentiated spermatogonia , which respectively derived from foetal germ cells and adult germ stem cells. Seminomas are the most frequent (50–70%) testicular germ cell tumours. Clinical and experimental studies suggested that oestrogens, the archetype of female hormones, participate in the physiological and pathological control of male germ cell proliferation , .","false","true","0.4770264","3","2","2","PLoS ONE","Reduced Immunogenicity of Induced Pluripotent Stem Cells Derived from Sertoli Cells","Wu, Qiang","Induced pluripotent stem cells (iPS cells) resemble embryonic stem cells (ES cells) and can differentiate into all cell types of our body . iPS cells are generated from somatic cells by expression of a defined set of transcription factors, including Oct4, Sox2, Klf4 and c-Myc (OSKM) . iPS cells have been successfully generated from a broad range of somatic cell types, such as fibroblasts, B lymphocytes, neural stem cells and hepatocytes –.","true","true","0.5608926","3","4","1"
"59","DIFFERENT_JOURNAL","PLoS ONE","Elevated Fasting Blood Glucose Is Predictive of Poor Outcome in Non-Diabetic Stroke Patients: A Sub-Group Analysis of SMART","Wang, Xiaoying","Ischemic stroke is one of the most common causes of disability and is considered now as the 4th leading cause of death []. Hyperglycaemia after acute ischemic stroke (AIS) is present at admission up to 60% of patients, not only in those with diabetes but also in a large proportion of non-diabetics[–].Increasing evidences suggest that hyperglycemia following AIS adversely affects clinical and morphological outcome.","Medicine (Baltimore)","Risk of Stroke in Patients With Spontaneous Pneumothorax","Calabrò., Rocco Salvatore","Stroke is a major cause of morbidity and disability as well as the most common cause of cardiovascular death worldwide. Moreover, stroke has been the 3rd leading cause of death in developed countries since 1990., Annually, stroke causes approximately 5.5 million deaths. According to the Taiwan Ministry of Health and Welfare, stroke is also the 3rd leading cause of death in Taiwan. Risk factors for stroke include diabetes mellitus, hypertension, hyperlipidemia, arrhythmia, smoking, low physical activity, and inflammation.","false","false","0.40988603","2","2","3","PLoS ONE","Neuroglobin Over Expressing Mice: Expression Pattern and Effect on Brain Ischemic Infarct Size","Deli, Maria A.","Stroke is a major cause of death and severe disability due to an increasing number of individuals being affected by stroke each year , . Stroke is the third most common cause of death in developed countries , and an enormous economic as well as social burden on society . About 85% of all strokes are ischemic, and most often due to a blood clot blockage of a cerebral artery . Despite intensive research in the field of ischemia, trombolysis within the narrow timeframe of three to six hours is to date the only effective treatment available , .","false","true","0.35544822","3","2","1","PLoS ONE","TLR Agonist Augments Prophylactic Potential of Acid Inducible Antigen  Rv3203 against  Mycobacterium tuberculosis H37Rv in Experimental Animals","Izzo, Angelo A.","The pathogen Mycobacterium tuberculosis (M. tuberculosis), the etiologic agent of human tuberculosis (TB), has been estimated to inflict around 9.6 million people (5.4 million men, 3.2 million women and 1.0 million children) world-wide up to the year 2014 [–]. Underlying these statistics is an emerging epidemic of multidrug-resistant tuberculosis (MDR-TB) and extremely drug resistance TB (XDR-TB) [–].","false","true","0.014898845","2","3","4","Medicine (Baltimore)","Imaging-Based Patient Selection and Endovascular Therapy of Ischemic Stroke","Guo., Weimin","Stroke is the second most common cause of death and the third most common cause of disability worldwide., Acute ischemic stroke due to large-vessel occlusion is the most common subtype of stroke. To date, intravenous tissue-type plasminogen activator (tPA) within 4.5 hours after symptom onset has been the only reperfusion therapy with proven efficacy in patients with acute ischemic stroke. However, patients with intracranial large-vessel occlusion are often not responsive to intravenous tPA, and 60–80% of these patients die within 90 days after stroke onset or do not regain functional independence despite intravenous tPA treatment.","false","false","0.4250067","3","3","2"
"60","SAME_JOURNAL","PLoS ONE","Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis","Tang, Chih-Hsin","Temporomandibular joint osteoarthritis (TMJ-OA) is a degenerative joint disease that is characterized by the death of chondrocytes, loss of cartilage extracellular matrix (ECM), and subchondral bone resorption in its early stages, followed by abnormal reparative bone turnover [–]. Under most conditions, osteoclast-mediated bone resorption and bone formation are tightly coupled. However, when the amount of bone resorption exceeds that of bone formation, subchondral bone loss often occurs [].","Maxillofac Plast Reconstr Surg","Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles","Kim, Kyung-Wook","In most edentulous patients who need dental implant, there is also no alveolar bone. Therefore, in many cases alveolar bone restoration is needed for implant treatment. Bone graft materials are usually divided into autogenous bone, allogenic bone, xenogenic bone and synthetic bone according to donor site. Autogenous bone is regarded as the ‘gold standard’ of bone graft because of its safety and effectiveness.","false","false","0.55541354","2","3","2","Pak J Med Sci","The role of healthy diet in the prevention of osteoporosis in perimenopausal period","Kostecka, Małgorzata","Osteoporosis is a skeletal disease characterized by low bone mass and disrupted bone architecture which increases bone brittleness and the risk of fracture. The loss of osseous tissue and bone lamellae in spongy bone proceeds faster than bone formation, leading to the loss of bone flexibility and stability. The loss of bone mass often proceeds unnoticed, it is a continuous process which may not produce any symptoms.","false","false","0.6066392","1","2","2","PLoS ONE","Quinoline Compound KM11073 Enhances BMP-2-Dependent Osteogenic Differentiation of C2C12 Cells via Activation of p38 Signaling and Exhibits  In Vivo Bone Forming Activity","Genetos, Damian Christopher","A delicate balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation is necessary for normal bone development and remodeling. Excessive osteoclastic bone resorption and/or reduced bone formation results in bone loss that consequently leads to pathological bone-related disorders, such as osteoporosis, rheumatoid arthritis, periodontal disease, and cancer bone metastasis [].","false","true","0.6920131","3","4","2","PLoS ONE","The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in  Sirt1 Null Cells","Tang, Chih-Hsin","Increased bone resorption by osteoclasts is characteristic of osteoporosis, inflammatory arthritis, hyperparathyroidism, malignant bone disease and other metabolic bone diseases. Currently available therapies to suppress osteoclast-mediated bone resorption include the bisphosphonates which induce osteoclast apoptosis and may result in suppression of bone formation and anti receptor activator of nuclear factor-κB ligand (RANKL)-antibody.","true","true","0.54337215","4","1","2"
"61","DIFFERENT_JOURNAL","PLoS Pathog","The  Arabidopsis Protein Phosphatase PP2C38 Negatively Regulates the Central Immune Kinase BIK1","Shan, Libo","Recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) initiates a complex signalling cascade leading to PRR-triggered immunity (PTI) [, ]. In plants, PRRs are plasma membrane (PM)-localized receptor kinases (RKs) or receptor-like proteins (RLPs) []. These PRRs typically form dynamic complexes with other regulatory RKs to initiate immune signalling [, ].","PLoS ONE","Cross Talk between Neuroregulatory Molecule and Monocyte: Nerve Growth Factor Activates the Inflammasome","Kanellopoulos, Jean","Innate immune response is initiated by the interaction of pattern recognition receptors (PRRs) in immune cells with either microbial pathogen associated molecular patterns (PAMPs) or cellular damage associated molecular patterns (DAMPs), resulting in the release of pro-inflammatory cytokines [, ]. Among multiple germ-line encoded PRRs, the nod-like receptor (NLR) proteins trigger the innate immune response through formation of the 'inflammasome' complex in order to tackle the PAMPs and DAMPs [, ].","false","false","0.5422177","1","2","2","PLoS Pathog","Transgenic Expression of the Dicotyledonous Pattern Recognition Receptor EFR in Rice Leads to Ligand-Dependent Activation of Defense Responses","Ma, Wenbo","Plants possess multi-layered immune systems enabling them to fend off most pathogens. Plasma membrane localized pattern recognition receptors (PRRs) sense danger-associated molecules, including pathogen/microbe-associated molecular patterns (P/MAMPs) and endogenous elicitors released during the infections process. The activation of PRRs triggers a rapid intracellular signaling cascade [–]. In most cases, PRR-triggered immunity (PTI) is sufficient to halt microbial replication and disease development [,].","false","true","0.53692484","2","3","1","PLoS ONE","Depleting Components of the THO Complex Causes Increased Telomere Length by Reducing the Expression of the Telomere-Associated Protein Rif1p","Lustig, Arthur J.","Telomeres are the structure at the ends of eukaryotic linear chromosomes , . They are essential for the maintenance of chromosome integrity, and protect natural DNA ends from being recognized as double-strand breaks. In most organisms, the telomeric DNA is composed of short, tandemly repeated sequences with a strand rich in guanine residues (G-strand) running 5′ to 3′ toward the end of the telomere.","false","false","0.0","2","1","3","PLoS ONE","S100A8 and S100A9 Induce Cytokine Expression and Regulate the NLRP3 Inflammasome via ROS-Dependent Activation of NF-κB1","Wilson, Emma H.","Endogenous signals originating from stressed, injured, and necrotic cells can activate the innate and adaptive immune systems . These signals have been termed as danger-associated molecular patterns (DAMPs) or alarmins . Like pathogen-associated molecular patterns, DAMPs are recognized by a variety of pathogen-recognition receptors (PRRs) including the toll-like receptors, the formyl-methionine receptors, and the receptor for advanced glycation end-products (RAGE) .","false","false","0.48","2","4","4"
"62","DIFFERENT_JOURNAL","PLoS ONE","Cut-Off Value for Pain Sensitivity Questionnaire in Predicting Surgical Success in Patients with Lumbar Disc Herniation","Grasso, Giovanni","Low back pain (LBP) has become one of the most serious public health problems []. Lumbar disc herniation (LDH) is one of the most common low back disorders associated with LBP. A herniated lumbar disc can press on the nerves in the spine and may cause pain, numbness, tingling or weakness in the foot []. Pain is a critical event in patients with spinal disorder that require attention from spine specialists [].","PLoS ONE","Genome-Wide Meta-Analysis of Sciatica in Finnish Population","Palmer, Nicholette D.","Low back pain is a global health problem affecting all age groups [, ]. Sciatica–usually a clinical manifestation of lumbar disc herniation (OMIM 603932)—is a common low back disorder with a population prevalence of about 5%; it is often disabling in the working age population [, ]. Sciatica is a complex disorder, with both genetic and environmental factors involved [, ]. Sciatic pain or lumbar radicular pain–the typical symptom of sciatica–is defined as pain radiating from the back down to the leg, usually caused by compression or irritation of one of the lumbosacral nerve roots [–].","false","true","0.48741743","2","2","4","PLoS ONE","FokI Polymorphism in the Vitamin D Receptor Gene ( VDR) and Its Association with Lumbar Spine Pathologies in the Italian Population: A Case-Control Study","Katoh, Masaru","Low back disorders, in particular disc herniation, which represents by far the most prevalent pathology causing pain and sciatica, constitute an important source of disability and one of the most cost-intensive health problems . In Western countries they represent the most common musculoskeletal diseases; it is estimated that 15–20% of adults experience back pain during a single year and around 50–80% have at least one episode during their lifetime .","false","true","0.4514212","3","4","3","PeerJ","Testing animal-assisted cleaning prior to transplantation in coral reef restoration","Costello, Mark","Active coral reef restoration is increasingly being seen as a new tool for conservation biology () as coral reefs continue to decline worldwide (). One of the several available coral reef restoration methods involves “coral gardening” in a two-step process. First, coral fragments are raised in underwater nurseries. Second, after reaching a target size, the nursery corals are harvested and transplanted onto degraded reef areas ().","false","false","0.023819653","2","3","2","Biol Sport","THE EFFECTS OF BACK EXTENSION TRAINING ON BACK MUSCLE STRENGTH AND SPINAL RANGE OF MOTION IN YOUNG FEMALES","Yaprak, Y.","Low back pain (LBP) is one of the most common public health problems in modern industrialized societies. Many lumbar problems are muscular in origin and persons suffering from LBP often have weak lumbar muscles []. Many studies have suggested that improved strength and endurance of the back musculature could aid in the prevention and treatment of LBP [].The spine is a lever subjected to external loads created by the weight of the trunk and any object lifted, and the forces created by the various muscles and ligaments surrounding the spine [].","false","false","0.4362202","2","1","1"
"63","SAME_JOURNAL","PLoS ONE","Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release","Price, Theodore John","Numerous genetic studies implicate Nav1.7 in the pathogenesis of distinct pain states (for reviews see [] []). In particular, loss-of-function mutations in SCN9A (the gene encoding Nav1.7) have been identified in patients with congenital insensitivity to pain (CIP; []), whereas gain-of-function mutations in SCN9A lead to chronic pain syndromes such as paroxysmal extreme pain disorder (PEPD, []) and inherited erythromelalgia (IEM) [] [] [] [].","PeerJ","Distinctive personality profiles of fibromyalgia and chronic fatigue syndrome patients","D’Acquisto, Fulvio","Fibromyalgia (FMS) is a syndrome characterized by chronic widespread musculoskeletal pain and tenderness, associated with disturbed sleep patterns, chronic fatigue and a spectrum of additional functional symptoms. While the pathogenesis and etiology of FMS remain incompletely understood, a leading paradigm in this aspect currently holds that FMS is the result of a process of pain centralization, whereby the central nervous system has become extremely hyper-sensitive to the processing and transmission of pain, thus causing amplification of painful as well as non-painful stimuli and leading to a state of chronic pain ().","false","false","0.42098457","2","2","2","J Pain Res","Spinal cord stimulation for neuropathic pain: current perspectives","Wolter, Tilman","Neuropathic pain constitutes a significant portion of chronic pain. The International Association for the Study of Pain defines neuropathic pain as pain caused by a lesion or disease of the somatosensory nervous system. Patients with neuropathic pain usually are more heavily burdened than patients with nociceptive pain and suffer more often from insomnia, anxiety, and depression. Moreover, analgetic medication often has an insufficient effect on neuropathic pain.","false","false","0.40741086","1","3","4","PLoS ONE","Pain Catastrophising Affects Cortical Responses to Viewing Pain in Others","Ptito, Maurice","Pain catastrophising has been defined as an exaggerated negative mental set brought to bear during the actual or anticipated pain experience [,] (reviewed in Quartana et al. []). In healthy people, high levels of pain catastrophising contribute to perceived pain intensity during experimental pain [,,]. Pain catastrophising is also associated with increased pain severity, pain behaviour, emotional distress and disability in patients with chronic pain such as osteoarthritis [,], rheumatoid arthritis [], spinal cord injury [], fibromyalgia [], low back pain [,], and musculoskeletal injury [,].","false","true","0.43481317","1","3","1","PLoS ONE","Basolateral Amygdala Lesion Inhibits the Development of Pain Chronicity in Neuropathic Pain Rats","Price, Theodore John","Neuropathic pain is a kind of chronic pain resulting from injury of somatosensory system. It is characterized by pain persistence even after original damages have been recovered . Its symptoms include allodynia, hyperalgesia and spontaneous pain. Many studies have demonstrated that several brain regions contribute to chronic pain by showing that pain is reduced after inactivation of brain regions at the late stage of chronic pain , .","true","true","0.42900404","3","2","3"
"64","SAME_AUTHOR","PLoS ONE","Increased Soluble CD155 in the Serum of Cancer Patients","Shiku, Hiroshi","Immune surveillance of tumors suppresses cancer development to protect the host. Key players in cell-mediated immunity to tumors, cytotoxic T lymphocytes (CTL) and NK cells [, ], mediate tumor recognition and activation through their antigen receptors and a variety of adhesion and costimulatory molecules [, ]. Interactions of cell surface receptors with their ligands expressed on tumor cells induce cytotoxic activity of CTL and NK cells against tumors [].","PLoS ONE","Alginic Acid-Coated Chitosan Nanoparticles Loaded with Legumain DNA Vaccine: Effect against Breast Cancer in Mice","He, Xiaoming","DNA-based vaccines provide protection against cancers in a variety of animal models , , , . Upon vaccination, host autoimmunity is activated, resulting in significant suppression of tumor growth and metastasis , , , , . Although conventional cancer DNA vaccines are designed to target tumor cells, more novel vaccines are being developed to target the specific contents in the tumor microenvironment , , , .","false","true","0.37313893","4","2","4","PLoS ONE","Increased CD112 Expression in Methylcholanthrene-Induced Tumors in CD155-Deficient Mice","Bai, Xue-feng","Cancer immune surveillance to suppress tumor development is an important host protection process. Several immune effector cell types and secreted cytokines play a critical role in this process. Among them, cytotoxic T lymphocytes (CTL) and natural killer (NK) cells are major players in cell-mediated immunity against tumors , . Interaction of cell surface receptors on CTL and NK cells with their respective ligands expressed on tumors activates the CTL and NK cells , , resulting in their secretion of cytokines and cytotoxicity against tumors , .","false","true","0.8147557","1","1","3","PLoS ONE","Combining α-Radioimmunotherapy and Adoptive T Cell Therapy to Potentiate Tumor Destruction","Shiku, Hiroshi","Radiation therapy is one of the most efficient form of cancer therapy, and is used in the treatment of more than half of all cancer patients [,]. Ionizing radiation is known for its direct cytotoxic action on tumor cells [] as well as the radiation-induced bystander effects which can destroy surrounding malignant cells [–]. Furthermore, impact of local radiotherapy on tumor immunity and immune cell activation has also been documented.","true","true","0.43123823","3","4","1","PLoS ONE","Development and Validation of a High Throughput System for Discovery of Antigens for Autoantibody Detection","Karagiannis, Sophia N.","The precise role of the immune system in cancer remains to be fully elucidated despite decades of research. It is known that a patient may display an immune response to tumor cells or tumor-derived or associated antigens (TAAs). This can result in the production of autoantibodies (AAb) against antigenic constituents of the cancer patient’s own tissues. Although the implications of this for tumor progression remain unclear, the presence of AAb in patients with cancer has raised the possibility that their measurement may be used as an aid to early cancer detection as well as selection and monitoring of treatment –.","false","true","0.31815377","2","3","2"
"65","SAME_JOURNAL","PLoS ONE","Inter-Fraction Tumor Volume Response during Lung Stereotactic Body Radiation Therapy Correlated to Patient Variables","Zhang, Qinghui","Stereotactic body radiation therapy (SBRT) or stereotactic ablative body radiotherapy (SABR) has become a highly effective radiation regimen for both early stage primary non-small cell lung cancer (NSCLC) and oligometastatic cancers to the lung. In this procedure, highly conformal and precise radiation doses of 50–60 Gy are delivered in 3–5 fractions to a malignant lung nodule, resulting in outstanding local control rate (>90% for early stage lung nodules).","PeerJ","Single-agent maintenance therapy for advanced non-small cell lung cancer (NSCLC): a systematic review and Bayesian network meta-analysis of 26 randomized controlled trials","Pintilie, Melania","Lung cancer is one of the most common malignant tumors and the leading cause of cancer-related death worldwide. It is estimated that about 224,390 new cases of lung and bronchus cancer will be diagnosed and 158,080 deaths will occur in 2016 in the United States alone (). Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases ().For early stage NSCLC, radical surgery or radiotherapy may result in relatively better prognosis.","false","false","0.42707413","3","2","4","Genet. Mol. Biol","Crude alkaloid extract of  Rhazya stricta inhibits cell growth and sensitizes human lung cancer cells to cisplatin through induction of apoptosis","Elkady, Ayman I.","Lung cancer is one of the most common cancers in many countries and accounts for 28% of all cancer-related deaths (; ). Clinically, lung cancer is classified into two groups, namely, small cell and non-small cell lung cancer (NSCLC). The latter is more prevalent, accounting for almost 85% of lung cancers (). Although early detection and treatment can improve the prognosis, only 15% of patients with NSCLC are diagnosed at an early stage since most lung cancer begins to grow silently without any symptoms until the cancer is in an advanced stage (; ; ), at which point the treatment options are generally limited to surgery or radiation.","false","false","0.45070478","2","2","3","PLoS ONE","Comparison of Two RapidArc Delivery Strategies in Stereotactic Body Radiotherapy of Peripheral Lung Cancer with Flattening Filter Free Beams","Deutsch, Eric","Lung cancer remains the most frequent cause of death from cancer in both men and women worldwide [, ]. Clinical studies have indicated that stereotactic body radiation therapy (SBRT) is effective for both primary and metastatic lung cancer. To patients with medically inoperable early stage peripheral non-small-cell lung cancer (NSCLC), SBRT has achieved a favorably high local control rate, up to 88–92% [].","false","true","0.5772139","3","2","2","PLoS ONE","Intermediate Megavoltage Photon Beams for Improved Lung Cancer Treatments","Zhang, Qinghui","Lung cancer has become the most common and deadly cancer in the world with estimated 1.59 million deaths each year, accounting for nearly one in five of the total cancer mortality worldwide []. In the United States, lung cancer accounts for more deaths than any other cancers in both men and women []. In recent years, stereotactic body radiation therapy (SBRT) has shown promising outcome in the radiotherapeutic management of early-stage non-small cell lung cancer (NSCLC) for inoperable lung cancer patients [].","true","true","0.4910206","1","2","2"
"66","SAME_AUTHOR","PLoS ONE","RY10-4 Inhibits the Proliferation of Human Hepatocellular Cancer HepG2 Cells by Inducing Apoptosis  In Vitro and  In Vivo","Coleman, William B.","According to the latest global cancer statistic, hepatocellular carcinoma is the third highest cause of cancer-related death worldwide []. As one of the major cancer treatment modalities, chemotherapy has effectiveness in prolonging and improving the quality of life for the patients []. Research of small molecular compounds with anti-tumor activity has great benefits for developing new chemotherapy agents.","PLoS ONE","The Prognosis of Breast Cancer Patients after Mastectomy and Immediate Breast Reconstruction: A Meta-Analysis","Coleman, William B.","Breast cancer is now the leading cause of cancer death among women in economically developing countries. This statistic represents a shift from the previous decade, during which the most common cause of death from cancer was cervical cancer[]. There are approximately 13 million new cases of breast cancer worldwide each year[]. Mastectomy is the primary treatment for breast cancer; however, it damages a patient’s body image and has adverse effects on emotions, psychology, and social life[].","true","true","0.4549661","3","3","3","PLoS ONE","Silybin-Mediated Inhibition of Notch Signaling Exerts Antitumor Activity in Human Hepatocellular Carcinoma Cells","Lee, Terence","Hepatocellular carcinoma (HCC) is currently the fifth most common cancer and the third leading cause of cancer-related deaths worldwide; over 600,000 patients die as a result of liver cancer annually. Despite significant advances in surgery and chemotherapy, the majority of patients with HCC die within one year of diagnosis . In addition, these treatment methods are often associated with side effects and inadequately treat the disease.","false","true","0.4412779","2","1","3","PLoS ONE","Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring  ST13 Gene","Han, Zhaozhong","Cancer is a major global public health concern. A total of 1,529,560 new cancer cases and 569,490 deaths from cancer occurred in the United States alone in 2010 . Colorectal cancer is the second highest cause of death in the USA and is the fourth most common cancer in men and the third most common cancer in women worldwide . Thus, it is essential for scientists and medical doctors to develop new strategies for colon cancer treatment.","false","true","0.46442038","3","2","2","PLoS ONE","Establishment and Characterization of 7 Novel Hepatocellular Carcinoma Cell Lines from Patient-Derived Tumor Xenografts","Mukhopadhyay, Partha","Liver cancer is one of the most common cancers worldwide. Based on a global cancer statistics study, liver cancer represents the fifth most frequently diagnosed cancer and the second most frequent cause of cancer death in men. It is the seventh and sixth in women respectively. The majority of new cases and deaths come from developing countries, such as China and India. Hepatocellular carcinoma (HCC) accounts for 70% to 80% of primary liver cancers in adults.","false","true","0.44260427","4","4","2"