December 15, 2020 Preprint Open Access

Marín Hernández, Eduardo; Franco Pasos, Manuel Vladimir; Armenta Tapia, Valeria Estefanía; Sánchez Tovar, Octavio Adolfo; Siordia Reyes, Alicia Georgina; Bautista Piña, Verónica

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{
  "inLanguage": {
    "alternateName": "spa", 
    "@type": "Language", 
    "name": "Spanish"
  }, 
  "description": "<p><strong>RESUMEN</strong></p>\n\n<p>Introducci&oacute;n: El liquen nitidus es una dermatosis inflamatoria infrecuente de causa desconocida que generalmente afecta a ni&ntilde;os y adultos j&oacute;venes. Se caracteriza por p&aacute;pulas brillantes, que de forma excepcional involucra u&ntilde;as y mucosa oral. Se presentan dos casos de liquen nitidus pedi&aacute;trico generalizado, uno con cambios ungueales asociados.</p>\n\n<p>Caso 1: Masculino de 5 a&ntilde;os de edad, present&oacute; una dermatosis de 18 meses de evoluci&oacute;n que involucraba cara, tronco, extremidades superiores e inferiores, caracterizada por lesiones papulares peque&ntilde;as y brillantes que conflu&iacute;an formando placas. Se tom&oacute; biopsia que corrobor&oacute; el diagnostico de liquen nitidus.</p>\n\n<p>Caso 2: Masculino de 18 a&ntilde;os de edad, consult&oacute; por p&aacute;pulas en dedos de las manos, tobillos y pene de 18 meses de evoluci&oacute;n. La dermatosis estaba caracterizada por p&aacute;pulas agrupadas del color de la piel, brillantes, con una disposici&oacute;n bilateral y sim&eacute;trica; presentaba <em>pits</em> en la l&aacute;mina ungueal. El diagn&oacute;stico cl&iacute;nico fue liquen nitidus con afecci&oacute;n ungueal, confirmado mediante estudio histopatol&oacute;gico.</p>\n\n<p>Conclusiones: Se reportan dos casos de liquen nitidus generalizado en edad pedi&aacute;trica, uno con afecci&oacute;n ungueal.&nbsp; Resulta trascedente la difusi&oacute;n cient&iacute;fica de estos casos, su correlaci&oacute;n histopatol&oacute;gica, as&iacute; como los resultados de los tratamientos utilizados para reducir la cronicidad y las recidivas de la enfermedad, especialmente considerando que los pacientes solicitan la evaluaci&oacute;n m&eacute;dica de forma tard&iacute;a por su car&aacute;cter benigno e indolente.</p>\n\n<p>Se realiza una revisi&oacute;n de la literatura disponible y se expone una propuesta para su clasificaci&oacute;n.</p>\n\n<p>&nbsp;</p>\n\n<p>&nbsp;</p>\n\n<p><strong>ABSTRACT</strong></p>\n\n<p>Introduction: Lichen nitidus is an uncommon inflammatory dermatosis of unknown cause that generally affects children and young adults. It is characterized by shiny papules, which exceptionally involves nails and oral mucosa. We present two cases of generalized pediatric lichen nitidus, one with associated nail changes.</p>\n\n<p>Case 1: A 5-year-old male presented an 18-month-old dermatosis involving the face, trunk, upper and lower extremities, characterized by small, shiny papular lesions that converged to form plaques. A biopsy was taken to corroborate the diagnosis of lichen nitidus.</p>\n\n<p>Case 2: 18-year-old male, consulted for papules of fingers, ankles and penis of 18 months of evolution. Dermatosis was characterized by bright, clustered skin-colored papules with a bilateral and symmetrical arrangement. It had pits in the nail plate. The clinical diagnosis was lichen nitidus with nail involvement confirmed by histopathological study.</p>\n\n<p>Conclusions: Two cases of generalized lichen nitidus in pediatric age are reported, one with nail involvement. The scientific dissemination of these cases, their histopathological correlation, as well as the results of the treatments used to reduce the chronicity and recurrences of the disease are relevant, especially considering that patients request medical evaluation late due to their benign and indolent nature.</p>\n\n<p>A review of the available literature is made and a proposal for its classification is made.</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Servicio de Dermatolog\u00eda Pedi\u00e1trica, UMAE Hospital de Pediatr\u00eda \"Dr. Silvestre Frenk Freund\", Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. Ciudad de M\u00e9xico, M\u00e9xico.", 
      "@id": "https://orcid.org/0000-0002-2610-3353", 
      "@type": "Person", 
      "name": "Mar\u00edn Hern\u00e1ndez, Eduardo"
    }, 
    {
      "affiliation": "Departamento de Dermatolog\u00eda y Micolog\u00eda M\u00e9dica, UMAE Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. Ciudad de M\u00e9xico, M\u00e9xico.", 
      "@type": "Person", 
      "name": "Franco Pasos, Manuel Vladimir"
    }, 
    {
      "affiliation": "Pediatr\u00eda, Hospital de G\u00edneco-Pediatr\u00eda y Medicina Familiar No. 31, Instituto Mexicano del Seguro Social. Baja California, M\u00e9xico.", 
      "@type": "Person", 
      "name": "Armenta Tapia, Valeria Estefan\u00eda"
    }, 
    {
      "affiliation": "Pediatr\u00eda, Hospital de G\u00edneco-Pediatr\u00eda y Medicina Familiar No. 31, Instituto Mexicano del Seguro Social. Baja California, M\u00e9xico.", 
      "@type": "Person", 
      "name": "S\u00e1nchez Tovar, Octavio Adolfo"
    }, 
    {
      "affiliation": "Servicio de Anatom\u00eda Patol\u00f3gica, UMAE Hospital de Pediatr\u00eda \"Dr. Silvestre Frenk Freund\", Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social. Ciudad de M\u00e9xico, M\u00e9xico.", 
      "@id": "https://orcid.org/0000-0002-4326-6875", 
      "@type": "Person", 
      "name": "Siordia Reyes, Alicia Georgina"
    }, 
    {
      "affiliation": "Servicio de Anatom\u00eda Patol\u00f3gica, Fundaci\u00f3n de C\u00e1ncer de Mama A. C. Ciudad de M\u00e9xico, M\u00e9xico.", 
      "@type": "Person", 
      "name": "Bautista Pi\u00f1a, Ver\u00f3nica"
    }
  ], 
  "headline": "Liquen nitidus generalizado en edad pedi\u00e1trica. Reporte de dos casos, uno de ellos con cambios ungueales", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2020-12-15", 
  "url": "https://zenodo.org/record/4323294", 
  "keywords": [
    "Liquen nitidus", 
    "Edad pedi\u00e1trica", 
    "Generalizada", 
    "Cambios ungueales", 
    "Pediatric age", 
    "Generalized", 
    "Nail changes"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.4323294", 
  "@id": "https://doi.org/10.5281/zenodo.4323294", 
  "@type": "ScholarlyArticle", 
  "name": "Liquen nitidus generalizado en edad pedi\u00e1trica. Reporte de dos casos, uno de ellos con cambios ungueales"
}