Journal article Open Access

Adjuvant Properties of Silver and Dimethyl Sulfoxide Nanoparticles in Studying Antibacterial Activity of Antibiotics against E. Coli

Inga Nikolaevna Ryumkina; Nikolay Nikolaevich Shkil; Ekaterina Vladimirovna Nefyodova; Nikolay Alekseevich Shkil; Grigory Antonovich Nozdrin; Marina Viсtorovna Lazareva; Olga Victorovna Rasputina

The research results showed that silver nanoparticles have adjuvant properties that increase the bactericidal performance of antibiotics, more than when mono-use with dimethyl sulfoxide (DMSO) and when they are co-cultured. The bactericidal activity of silver nanoparticles against E. coli (Escherichia coli) ATCC 25922 was 0.08, and the E. coli isolate was 0.32 μg / ml. The study of the bactericidal activity with dimethyl sulfoxide for E. coli ATCC 25922 made it possible to establish it at the level of 9.75, and for the E. coli isolate is 4.86 μg / ml. The reference E. coli strain ATCC 25922 had the highest sensitivity of both AgNPs and their combination with antibiotics in comparison with the E. coli isolate, which was isolated from an animal with clinical manifestation of an infectious disease.
The combination of AgNPs and the antibiotic enrofloxacin, gentamicin, ceftimag, cypromag, oxytetracycline, ampicillin showed the greatest increase in bactericidal activity against both E. coli ATCC 25922 and E. coli isolate than AgNPs + antibiotic + DMSO, except for cloxacillin's in the study with isolate E. coli.

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