{ "access": { "embargo": { "active": false, "reason": null }, "files": "public", "record": "public", "status": "open" }, "created": "2021-01-21T08:58:29.440558+00:00", "custom_fields": { "journal:journal": { "title": "Annals of Biomedical Engineering" } }, "deletion_status": { "is_deleted": false, "status": "P" }, "files": { "count": 1, "enabled": true, "entries": { "PJWANG_ABME_FINAL 2020 PDF.pdf": { "checksum": "md5:bca377c5957e2c4f7a16f6f169222d0c", "ext": "pdf", "id": "0efd6547-c4bc-4060-8f2c-023ffc461a23", "key": "PJWANG_ABME_FINAL 2020 PDF.pdf", "metadata": null, "mimetype": "application/pdf", "size": 1522255 } }, "order": [], "total_bytes": 1522255 }, "id": "4268300", "is_draft": false, "is_published": true, "links": { "access": "https://zenodo.org/api/records/4268300/access", "access_links": "https://zenodo.org/api/records/4268300/access/links", "access_request": "https://zenodo.org/api/records/4268300/access/request", "access_users": "https://zenodo.org/api/records/4268300/access/users", "archive": "https://zenodo.org/api/records/4268300/files-archive", "archive_media": "https://zenodo.org/api/records/4268300/media-files-archive", "communities": "https://zenodo.org/api/records/4268300/communities", "communities-suggestions": "https://zenodo.org/api/records/4268300/communities-suggestions", "doi": "https://doi.org/10.1007/s10439-020-02673-z", "draft": "https://zenodo.org/api/records/4268300/draft", "files": "https://zenodo.org/api/records/4268300/files", "latest": "https://zenodo.org/api/records/4268300/versions/latest", "latest_html": "https://zenodo.org/records/4268300/latest", "media_files": "https://zenodo.org/api/records/4268300/media-files", "parent": "https://zenodo.org/api/records/4268299", "parent_doi": "https://zenodo.org/doi/", "parent_html": "https://zenodo.org/records/4268299", "requests": "https://zenodo.org/api/records/4268300/requests", "reserve_doi": "https://zenodo.org/api/records/4268300/draft/pids/doi", "self": "https://zenodo.org/api/records/4268300", "self_doi": "https://zenodo.org/doi/10.1007/s10439-020-02673-z", "self_html": "https://zenodo.org/records/4268300", "self_iiif_manifest": "https://zenodo.org/api/iiif/record:4268300/manifest", "self_iiif_sequence": "https://zenodo.org/api/iiif/record:4268300/sequence/default", "versions": "https://zenodo.org/api/records/4268300/versions" }, "media_files": { "count": 0, "enabled": false, "entries": {}, "order": [], "total_bytes": 0 }, "metadata": { "creators": [ { "affiliations": [ { "name": "Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA" } ], "person_or_org": { "family_name": "Wang", "given_name": "Pei-Jiang", "name": "Wang, Pei-Jiang", "type": "personal" } }, { "affiliations": [ { "name": "Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA, Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy" } ], "person_or_org": { "family_name": "Berti", "given_name": "Francesca", "name": "Berti, Francesca", "type": "personal" } }, { "affiliations": [ { "name": "Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy" } ], "person_or_org": { "family_name": "Antonini", "given_name": "Luca", "name": "Antonini, Luca", "type": "personal" } }, { "affiliations": [ { "name": "Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA" } ], "person_or_org": { "family_name": "Nezami", "given_name": "Farhad Rikhtegar", "name": "Nezami, Farhad Rikhtegar", "type": "personal" } }, { "affiliations": [ { "name": "Department of Civil and Environmental Engineering, Politecnico di Milano, Milan, Italy." } ], "person_or_org": { "family_name": "Petrini", "given_name": "Lorenza", "name": "Petrini, Lorenza", "type": "personal" } }, { "affiliations": [ { "name": "Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA, Laboratory of Biological Structure Mechanics, Department of Chemistry, Materials and Chemical Engineering 'Giulio Natta', Politecnico di Milano, Milan, Italy" } ], "person_or_org": { "family_name": "Migliavacca", "given_name": "Francesco", "name": "Migliavacca, Francesco", "type": "personal" } }, { "affiliations": [ { "name": "Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA and Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA" } ], "person_or_org": { "family_name": "Edelman", "given_name": "Elazer R.", "name": "Edelman, Elazer R.", "type": "personal" } } ], "description": "
Bioresorbable vascular scaffolds were considered the fourth generation of endovascular implants deemed to revolutionize cardiovascular interventions. Yet, unexpected high risk of scaffold thrombosis and post-procedural myocardial infractions quenched the early enthusiasm and highlighted the gap between benchtop predictions and clinical observations. To better understand scaffold behavior in the mechanical environment of vessels, animal, and benchtop tests with multimodal loading environment were conducted using industrial standard scaffolds. Finite element analysis was also performed to study the relationship among structural failure, scaffold design, and load types. We identified that applying the combination of bending, axial compression, and torsion better reflects incidence observed in vivo, far more than tranditional single mode loads. Predication of fracture locations is also more accurate when at least bending and axial compression are applied during benchtop tests (>60% fractures at connected peak). These structural failures may be initiated by implantation-induced microstructural damages and worsened by cyclic loads from the beating heart. Ignoring the multi-modal loading environment in benchtop fatigue tests and computational platforms can lead to undetected potential design defects, calling for redefining consensus evaluation strategies for scaffold performance. With the robust evaluation strategy presented herein, which exploits the results of in-vivo, in-vitro and in-silico investigations, we may be able to compare alternative designs of prototypes at the early stages of device development and optimize the performance of endovascular implants according to patients-specific vessel dynamics and lesion configurations in the future.
", "funding": [ { "award": { "acronym": "InSilc", "id": "00k4n6c32::777119", "identifiers": [ { "identifier": "https://cordis.europa.eu/projects/777119", "scheme": "url" } ], "number": "777119", "program": "H2020", "title": { "en": "InSilc: In-silico trials for drug-eluting BVS design, development and evaluation" } }, "funder": { "id": "00k4n6c32", "name": "European Commission" } } ], "publication_date": "2020-10-29", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "coronary stents/scaffolds, polylactic acid, polymer mechanics, finite 53 element, animal study, scaffold fracture, patient-specific, design optimization" } ], "title": "Multimodal Loading Environment Predicts Bioresorbable Vascular Scaffolds' Durability" }, "parent": { "access": { "owned_by": { "user": 152239 } }, "communities": { "entries": [ { "access": { "member_policy": "open", "members_visibility": "restricted", "record_policy": "open", "review_policy": "closed", "visibility": "public" }, "children": { "allow": true }, "created": "2022-11-23T15:53:29.436323+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "f0a8b890-f97a-4eb2-9eac-8b8a712d3a6c", "links": {}, "metadata": { "curation_policy": "The EU Open Research Repository serves as a repository for research outputs (data, software, posters, presentations, publications, etc) which have been funded under an EU research funding programme such as Horizon Europe, Euratom or earlier Framework Programmes.
\nThe community is managed by CERN on behalf of the European Commission.
\nZenodo’s general policies and Terms of Use apply to all content.
\nThe EU Open Research Repository accepts all digital research objects which is a research output stemming from one of EU’s research and innovation funding programmes. The funding programmes currently include:
\nHorizon Europe (including ERC, MSCA), earlier Framework Programmes (eg Horizon 2020) as well as Euratom.
\nIn line with the principle as open as possible, as closed as necessary both public and restricted content is accepted. See note on how Zenodo handles restricted content.
\nEU programme beneficiaries are eligible to submit content to the community. The community supports three types of content submissions:
\nSubmission via an EU Project Community (through user interface or programmatic APIs).
\nSubmission directly to the EU Open Research Repository.
\nAutomated harvesting from existing Zenodo content.
\nA representative of an EU project may request an EU Project Community and invite other project participants as members of the community. The project community is linked to one or more European Commission grants. All records in the project community are automatically integrated into the EU Open Research Repository immediately upon acceptance into the project community.
\nAny user may submit a record directly to the EU Open Research Repository. The submission will be moderated by Zenodo staff for compliance with the minimal required metadata requirements and its correctness.
\nRecords found among Zenodo’s existing content will on a regular basis automatically be integrated if they are found to comply with the requirements. The submissions through this method are integrated into the EU Open Research Repository with delay in a fully automated way.
\nRecords in the EU Open Research Repository are required to comply with the following minimal metadata requirements:
\nVisibility: Both public and restricted (with or without embargo and/or access request)
\nResource types: All resource types.
\nLicenses: Public and embargoed records MUST specify a license.
\nFunding information: Records MUST specify at least one grant from the European Commission.
\nCreators: Creators SHOULD be identified with a persistent identifier (e.g. ORCID, GND, …), and affiliations SHOULD be identified with a persistent identifier (e.g. ROR, ISNI, …)
\nSubjects: Records SHOULD specify one or more fields of science from the European Science Vocabulary.
\nAll submissions will undergo automated curation checks for compliance with the policy. Submissions through project communities are reviewed by the project community. Submission directly to the EU Open Research Repository is reviewed by Zenodo staff.
\nCommunity curators may at any point edit metadata of the records in the community without notice through human or automated processing. The curators may at their sole discretion remove records from the community that are deemed not to comply with the content and curation policy or which are deemed of insufficient quality.
\nThe content and curation policy is subject to change by the community owner at any time and without notice, other than through updating this page.
", "description": "Open repository for EU-funded research outputs from Horizon Europe, Euratom and earlier Framework Programmes.", "organizations": [ { "id": "00k4n6c32" } ], "page": "The EU Open Research Repository is a Zenodo-community dedicated to fostering open science and enhancing the visibility and accessibility of research outputs funded by the European Union. The community is managed by CERN on behalf of the European Commission.
\nThe mission of the repository is to support the implementation of the EU's open science policy, providing a trusted and comprehensive space for researchers to share their research outputs such as data, software, reports, presentations, posters and more. The EU Open Research Repository simplifies the process of complying with open science requirements, ensuring that research outputs from Horizon Europe, Euratom, and earlier Framework Programmes are freely accessible, thereby accelerating scientific discovery and innovation.
\nThe EU Open Research Repository serves as a complementary platform to the Open Research Europe (ORE) publishing platform. Open Research Europe focuses on providing a publishing venue for peer-reviewed articles, ensuring that research meets rigorous academic standards. The EU Open Research Repository provides a space for all the other research outputs including data sets, software, posters, and presentations that are out of scope for ORE. This holistic approach enables researchers to not only publish their findings but also share the underlying data and materials that support their work, fostering transparency and reproducibility in the scientific process.
\nCurrently in its pilot phase and set to be fully operational during autumn 2024, the EU Open Research Repository is constantly evolving. Efforts are committed to integrating cutting-edge features, including automated curation checks and FAIR (Findable, Accessible, Interoperable, and Reusable) assistance, to further support the research community. The goal is to provide researchers with a simple goto solution for making their publicly funded research open and as FAIR as possible.
\nThe EU Open Research Repository is funded by the European Union under grant agreement no. 101122956(HORIZON-ZEN). For more information about the project see https://about.zenodo.org/projects/horizon-zen/.
", "title": "EU Open Research Repository (Pilot)", "type": { "id": "organization" }, "website": "https://research-and-innovation.ec.europa.eu" }, "revision_id": 16, "slug": "eu", "theme": { "brand": "horizon", "enabled": true, "style": { "font": { "family": "Arial, sans-serif", "size": "16px", "weight": 600 }, "mainHeaderBackgroundColor": "#FFFFFF", "primaryColor": "#004494", "primaryTextColor": "#FFFFFF", "secondaryColor": "#FFD617", "secondaryTextColor": "#000000", "tertiaryColor": "#e3eefd", "tertiaryTextColor": "#1c5694" } }, "updated": "2024-03-20T06:47:47.577483+00:00" } ], "ids": [ "f0a8b890-f97a-4eb2-9eac-8b8a712d3a6c" ] }, "id": "4268299", "pids": {} }, "pids": { "doi": { "identifier": "10.1007/s10439-020-02673-z", "provider": "external" }, "oai": { "identifier": "oai:zenodo.org:4268300", "provider": "oai" } }, "revision_id": 2, "stats": { "all_versions": { "data_volume": 197893150.0, "downloads": 130, "unique_downloads": 128, "unique_views": 29, "views": 32 }, "this_version": { "data_volume": 196370895.0, "downloads": 129, "unique_downloads": 127, "unique_views": 29, "views": 32 } }, "status": "published", "updated": "2021-01-21T12:27:19.114951+00:00", "versions": { "index": 1, "is_latest": true } }