4268282
doi
10.1016/j.physbeh.2020.113014
oai:zenodo.org:4268282
Miedl, Stephan F.
Department of Psychology, Division of Clinical Psychology and Psychopathology, Paris-Lodron-University of Salzburg, Hellbrunner Str. 34, 15020 Salzburg, Austria
Wilhelm, Frank H.
Department of Psychology, Division of Clinical Psychology and Psychopathology, Paris-Lodron-University of Salzburg, Hellbrunner Str. 34, 15020 Salzburg, Austria
Miller, Joe
Department of Psychology, Centre for Cognitive Neuroscience, Paris-Lodron-University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria
Blechert, Jens
Department of Psychology, Centre for Cognitive Neuroscience, Paris-Lodron-University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria
Love at first taste: Activation in reward-related brain regions during single-trial naturalistic appetitive conditioning in humans
Lender, Anja
Department of Psychology, Centre for Cognitive Neuroscience, Paris-Lodron-University of Salzburg, Hellbrunner Str. 34, 5020 Salzburg, Austria
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Affective neuroscience
Appetitive conditioning
Food craving
Incentive salience
Caudate
Amygdala
<p>Palatable food can trigger appetitive responses, such as salivation and approach tendencies. Though evolutionarily functional, these conditioned responses can encourage overeating and obesity when food is abundant. The current study examines the neural correlates of ‘denovo’ Pavlovian appetitive conditioning, pairing one class of unknown objects (conditioned stimuli, CS) with their sweet taste (unconditioned stimulus, US) during a single trial. To do so, 23 participants consumed unknown (marzipan) objects of one particular color (CS+) while only interacting with control stimuli of different color and shape (CS-). After this single-trial conditioning procedure, participants viewed and rated images of the marzipan figures and the control objects during functional magnetic resonance imaging (fMRI). Relative to the CS-, the CS+ elicited stronger activation in the dorsal striatum, a brain region associated with cue-reward coupling. Furthermore, conditioning effects in subjective ‘craving’, defined as increased palatability and desire to eat, were observed, and these were positively related to conditioning effects in the amygdala, a brain region associated with the need-dependent value of a reward. Thus, the study identified reward-related brain regions involved in single-trial appetitive learning, thereby providing a potential mechanism that contributes to the etiology of food craving. These findings might help to understand clinically relevant food cravings in individuals with eating or weight related concerns and might support the development of extinction based treatments.</p>
Zenodo
2020-10-01
info:eu-repo/semantics/article
4268281
award_title=Imaging the Mind: consciousness, higher mental and social processes; award_number=W 1233; funder_id=013tf3c58; funder_name=FWF Austrian Science Fund;
award_title=Transdiagnostic views on eating disorders and obesity and new approaches for treatment; award_number=639445; award_identifiers_scheme=url; award_identifiers_identifier=https://cordis.europa.eu/projects/639445; funder_id=00k4n6c32; funder_name=European Commission;
1605184030.233393
823247
md5:e573a270aa134089943c16db1d0a5227
https://zenodo.org/records/4268282/files/1-s2.0-S0031938420303280-main.pdf
public