4247133
doi
10.5281/zenodo.4247133
oai:zenodo.org:4247133
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SYNTHESIS, CHARACTERIZATION & IN-VITRO ACTIVITY OF NEW SERIES OF COUMARIN SUBSTITUTED MERCAPTO-1, 3, 4-OXADIAZOLE DERIVATIVES AS GSK-3β INHIBITORS.
Purohit S.S.*, Kulkarni V.H., Joshi S.D.
S.E.T.'s College of Pharmacy, S.R.Nagar, Near Microwave Tower, Dharwad-580002, India
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Coumarin Hydrazides, Mercapto-1,3,4-Oxadiazoles, In-Vitro GSK3-β Activity.
<p>A new series of 2, 5-disubstituted-mercapto-1,3,4-oxadiazole derivatives were synthesized in good yield by reacting different coumarin hydrazide with carbon disulfide & further reacting with various aryl halides. The reactions were monitored by TLC & all derivatives were purified by recrystallization using suitable solvents. The synthesized derivatives were characterized by IR,1H-NMR, Mass spectral data. Further these derivatives were studied for their in-vitro GSK-3β inhibitory activity by using Kinase-Glo Plus luminescence kinase assay & percentage inhibitions were calculated. The standard compound used was CHIR-99021. Some of the derivatives have shown significant in-vitro activity.</p>
Zenodo
2020-11-05
info:eu-repo/semantics/article
4247132
user-iajpr
1604622421.687455
780321
md5:7285900dfebdac9c7c9963ed077dcd2e
https://zenodo.org/records/4247133/files/200905.pdf
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10.5281/zenodo.4247132
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doi