EreƱo Artabe, Amaia
Cunha-Silva, Hugo
Barranco
2020-08-15
<p>Halogenated organic compounds are a particular group of contaminants consisting of a large number of substances, and of great concern due to their persistence in the environment, potential for bioaccumulation and toxicity. Some of these compounds have been classified as persistent organic pollutants (POPs) under The Stockholm Convention and many toxicity assessments have been conducted on them previously. In this work we provide an overview of enzymatic assays used in these studies to establish toxic effects and dose-response relationships. Studies <em>in vivo</em> and <em>in vitro</em> have been considered with a particular emphasis on the impact of halogenated compounds on the activity of relevant enzymes to the humans and the environment. Most information available in the literature focuses on chlorinated compounds, but brominated and fluorinated molecules are also the target of increasing numbers of studies. The enzymes identified can be classified as enzymes: <em>i)</em> the activities of which are affected by the presence of halogenated organic compounds, and <em>ii)</em> those involved in their metabolisation/detoxification resulting in increased activities. In both cases the halogen substituent seems to have an important role in the effects observed. Finally, the use of these enzymes in biosensing tools for monitoring of halogenated compounds is described.</p>
This work was also supported by the Spanish Ministry of Economy and Competitiveness (Project QUALSAFeFOOD, grant code CTQ2017-83569-C2-2-R).
https://doi.org/10.1016/j.fct.2020.111677
oai:zenodo.org:4108898
eng
Zenodo
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https://zenodo.org/communities/seafoodtomorrow
info:eu-repo/semantics/openAccess
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EnzymesHalogenated organic contaminantsToxicityIn vitroIn vivoBiosensors
Enzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review
info:eu-repo/semantics/article