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HPLC-DAD-ESI-QTOF-MS Determination of Bioactive Compounds and Antioxidant Activity Comparison of the Hydroalcoholic and Water Extracts from Two Helichrysum italicum Species

Katja Kramberger; Darja Barlič-Maganja; Dunja Bandelj; Alenka Baruca Arbeiter; Kelly Peeters; Ana Miklavčič Višnjevec; Zala Jenko Pražnikar


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    "doi": "10.3390/metabo10100403", 
    "description": "<p>Mediterranean plant&nbsp;Helichrysum italicum&nbsp;represents a rich source of versatile bioactive compounds with potential benefits for human health. Despite extensive research on the plant&rsquo;s active constituents, little attention has yet been paid to characterizing the relationship between its intra-specific genetic diversity and metabolite profile. The study aimed to determine metabolic profile of&nbsp;H. italicum&nbsp;ssp.&nbsp;italicum&nbsp;(HII) and ssp.&nbsp;tyrrhenicum&nbsp;(HIT) cultivated on the experimental plantation in Slovenia and to compare the chemical composition of extracts regarding the solvent extraction process. Extracts were prepared upon conventional extract preparation procedures: maceration with 50% methanol or ethanol and cold or hot water infusion and analyzed using High Performance Liquid Chromatography-Diode Array Detection-Electrospray Ionization-Quadrupole Time-of-Flight-Mass Spectrometry (HPLC-DAD-ESI-QTOF-MS). One hundred compounds were identified in the samples, among them several isomers and derivatives were reported for the first time, while caffeoylquinic acids and pyrones were the most abundant. Semi-quantitative comparison revealed that the extraction procedure had a greater impact on the chemical profile than genetic variability. All&nbsp;HIT&nbsp;extracts showed a higher total phenolic content compared to&nbsp;HII, while the antioxidant potential evaluated by 1,1-diphenyl-2-picrylhydrazil test was not proportionally higher. In addition, hot water extracts proved to be comparably active as alcoholic ones, confirming high commercial potential of&nbsp;Helichrysum italicum&nbsp;as herbal functional beverages.</p>", 
    "alternate_identifiers": [
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        "identifier": "2218-1989"
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    "title": "HPLC-DAD-ESI-QTOF-MS Determination of Bioactive Compounds and Antioxidant Activity Comparison of the Hydroalcoholic and Water Extracts from Two Helichrysum italicum Species", 
    "license": {
      "id": "CC-BY-4.0"
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    "journal": {
      "volume": "10", 
      "issue": "10", 
      "title": "Metabolites"
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        "program": "H2020", 
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    "keywords": [
      "H. italicum", 
      "plant extracts", 
      "phenolic compounds", 
      "antioxidant activity", 
      "HPLC-DAD-ESI-QTOF-MS"
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    "publication_date": "2020-10-12", 
    "creators": [
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        "orcid": "0000-0003-4589-0644", 
        "affiliation": "Faculty of Health Sciences, University of Primorska, Slovenia; Faculty of Medicine, University of Ljubljana, Slovenia", 
        "name": "Katja Kramberger"
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      {
        "affiliation": "Faculty of Health Sciences, University of Primorska, Slovenia", 
        "name": "Darja Barli\u010d-Maganja"
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      {
        "affiliation": "Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Slovenia", 
        "name": "Dunja Bandelj"
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      {
        "affiliation": "Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Slovenia", 
        "name": "Alenka Baruca Arbeiter"
      }, 
      {
        "affiliation": "InnoRenew CoE, Slovenia; Andrej Maru\u0161i\u010d Institute, University of Primorska, Slovenia", 
        "name": "Kelly Peeters"
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      {
        "affiliation": "Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Slovenia", 
        "name": "Ana Miklav\u010di\u010d Vi\u0161njevec"
      }, 
      {
        "affiliation": "Faculty of Health Sciences, University of Primorska, Slovenia", 
        "name": "Zala Jenko Pra\u017enikar"
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