Dataset Open Access

Smoking is associated with worse outcomes of COVID-19 particularly among younger adults: a systematic review and meta-analysis

Glantz, Stanton; Patanavanich, Roengrudee


JSON-LD (schema.org) Export

{
  "description": "<p><strong>Introduction: </strong>Smoking impairs lung immune functions and damages upper airways, increasing risks of contracting and severity of infectious diseases.</p>\n\n<p><strong>Methods: </strong>We searched PubMed for studies published from January 1-May 25, 2020. We included studies reporting smoking behavior of COVID-19 patients and progression of disease, including death. We used a random effects meta-analysis and used meta-regression and lowess regressions to examine relationships in the data.</p>\n\n<p><strong>Results: </strong>We identified 47 peer-reviewed papers with a total of 31,871 COVID-19 patients, 5,759 (18.1%) experienced disease progression and 5,734 (18.0%) with a history of smoking. Among smokers, 29.2% experienced disease progression, compared with 21.1% of non-smokers. The meta-analysis confirmed an association between smoking and COVID-19 progression (OR 1.56, 95% CI 1.32-1.83, p=0.001). Smoking was associated with increased risk of death from COVID-19 (OR 1.19, 95% CI 1.05-1.34, p=0.007). We found no significant difference (p=0.432) between the effects of smoking on COVID-19 disease progression between adjusted and unadjusted analyses, suggesting that smoking is an independent risk factor for COVID-19 disease progression. We also found the risk of having COVID-19 progression among younger adults (p=0.023), with the effect most pronounced among people under about 45 years old.</p>\n\n<p><strong>Conclusions: </strong>Smoking is an independent risk for having severe progression of COVID-19, including mortality. The effects seem to be higher among young people.</p>\n\n<p><strong>Implications:</strong> Smoking prevention and cessation should remain a priority for the public, physicians, and public health professionals during the COVID-19 pandemic.</p>", 
  "license": "https://creativecommons.org/publicdomain/zero/1.0/legalcode", 
  "creator": [
    {
      "affiliation": "University of California San Francisco Medical Center", 
      "@id": "https://orcid.org/0000-0002-8357-8961", 
      "@type": "Person", 
      "name": "Glantz, Stanton"
    }, 
    {
      "affiliation": "University of California San Francisco Medical Center", 
      "@type": "Person", 
      "name": "Patanavanich, Roengrudee"
    }
  ], 
  "url": "https://zenodo.org/record/4086492", 
  "measurementTechnique": "<p>We conducted a systematic search using PubMed on May 25, 2020, with the search term: \"((smoking) OR (characteristics) OR (risk factors) OR (retrospective*) OR (outcomes) OR (smoker*)) AND ((COVID-19) OR (COVID) OR (coronavirus) OR (sars cov-2) OR (sars cov 2))\" for studies published between January 1, 2020 and May 25, 2020. A total of 2,600 studies were retrieved through the search.</p>", 
  "datePublished": "2020-09-30", 
  "@context": "https://schema.org/", 
  "distribution": [
    {
      "contentUrl": "https://zenodo.org/api/files/9500c97d-e280-45ca-b47b-4ef5f0d426ea/COVID_DataSingleFile.dta", 
      "encodingFormat": "dta", 
      "@type": "DataDownload"
    }, 
    {
      "contentUrl": "https://zenodo.org/api/files/9500c97d-e280-45ca-b47b-4ef5f0d426ea/DO_FILE_COVID2_BMC.do", 
      "encodingFormat": "do", 
      "@type": "DataDownload"
    }
  ], 
  "identifier": "https://doi.org/10.7272/Q6CF9NBQ", 
  "@id": "https://doi.org/10.7272/Q6CF9NBQ", 
  "@type": "Dataset", 
  "name": "Smoking is associated with worse outcomes of COVID-19 particularly among younger adults: a systematic review and meta-analysis"
}
57
23
views
downloads
Views 57
Downloads 23
Data volume 454.2 kB
Unique views 46
Unique downloads 20

Share

Cite as