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Diets supplemented with Saccharina latissima influence the expression of genes related to lipid metabolism and oxidative stress modulating rainbow trout (Oncorhynchus mykiss) fillet composition

Mariana Ferreira; Bodil Katrine Larsen; Kit Granby; Sara C. Cunha; Carolina Monteiro; José O. Fernandes; Maria L. Nunes; António Marques; Jorge Dias; Isabel Cunha; L. Filipe C. Castro; Luísa M.P. Valente


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  <identifier identifierType="URL">https://zenodo.org/record/4081428</identifier>
  <creators>
    <creator>
      <creatorName>Mariana Ferreira</creatorName>
      <affiliation>CIIMAR; ICBAS</affiliation>
    </creator>
    <creator>
      <creatorName>Bodil Katrine Larsen</creatorName>
      <affiliation>DTU, National Institute of Aquatic Resources</affiliation>
    </creator>
    <creator>
      <creatorName>Kit Granby</creatorName>
      <affiliation>DTU, National Food Institute</affiliation>
    </creator>
    <creator>
      <creatorName>Sara C. Cunha</creatorName>
      <affiliation>LAQV-REQUIMTE</affiliation>
    </creator>
    <creator>
      <creatorName>Carolina Monteiro</creatorName>
      <affiliation>LAQV-REQUIMTE</affiliation>
    </creator>
    <creator>
      <creatorName>José O. Fernandes</creatorName>
      <affiliation>LAQV-REQUIMTE</affiliation>
    </creator>
    <creator>
      <creatorName>Maria L. Nunes</creatorName>
      <affiliation>CIIMAR</affiliation>
    </creator>
    <creator>
      <creatorName>António Marques</creatorName>
      <affiliation>CIIMAR; IPMA</affiliation>
    </creator>
    <creator>
      <creatorName>Jorge Dias</creatorName>
      <affiliation>Sparos Lda.</affiliation>
    </creator>
    <creator>
      <creatorName>Isabel Cunha</creatorName>
      <affiliation>CIIMAR</affiliation>
    </creator>
    <creator>
      <creatorName>L. Filipe C. Castro</creatorName>
      <affiliation>CIIMAR; FCUP</affiliation>
    </creator>
    <creator>
      <creatorName>Luísa M.P. Valente</creatorName>
      <affiliation>CIIMAR; ICBAS</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Diets supplemented with Saccharina latissima influence the expression of genes related to lipid metabolism and oxidative stress modulating rainbow trout (Oncorhynchus mykiss) fillet composition</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2020</publicationYear>
  <subjects>
    <subject>Oncorhynchus mykiss</subject>
    <subject>Sugar kelp</subject>
    <subject>Oxidative stress</subject>
    <subject>Lipid metabolism</subject>
    <subject>Fillet composition</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2020-04-17</date>
  </dates>
  <resourceType resourceTypeGeneral="JournalArticle"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/4081428</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.fct.2020.111332</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/seafoodtomorrow</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;This study aimed to evaluate the impact of diets including increasing amounts (1, 2 and 4%) of an iodine-rich macroalgae, &lt;em&gt;Saccharina latissima&lt;/em&gt;, on gene expression and fillet composition of commercial-sized rainbow trout. Liver and muscle expression of genes related to growth, iodine, oxidative stress, and lipid metabolism, and the fillet content of fatty acids, cholesterol, and vitamin D3 were assessed. The highest kelp inclusion led to lower final body weight and HSI, without significant differences in mRNA transcription of genes involved in growth (&lt;em&gt;ghr1&lt;/em&gt;, &lt;em&gt;ghr2 &lt;/em&gt;and &lt;em&gt;igf1&lt;/em&gt;) or iodine metabolism (&lt;em&gt;dio1&lt;/em&gt;, &lt;em&gt;thra&lt;/em&gt;, and &lt;em&gt;thrb&lt;/em&gt;). A significant downregulation of an oxidative stress marker, &lt;em&gt;gpx1b2&lt;/em&gt;, was observed in fish fed 2% &lt;em&gt;S. latissima&lt;/em&gt;, which might suggest the need for less endogenous antioxidants. Dietary inclusion of kelp impacted lipid metabolism, with a downregulation of fatty acid synthase, accompanied by a general decrease of fatty acids in fillet. The present study demonstrated that supplementation of diets with 1 or 2% &lt;em&gt;S. latissima &lt;/em&gt;can be achieved without detrimental effects on rainbow trout final weight. Evidence suggest a lipid-lowering effect of diets that did not compromised fillet EPA and DHA concentrations, being 3.7 times above the recommended levels for human consumption.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/H2020/773400/">773400</awardNumber>
      <awardTitle>Nutritious, safe and sustainable seafood for consumers of tomorrow</awardTitle>
    </fundingReference>
  </fundingReferences>
</resource>
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