Journal article Open Access

Microencapsulation of dronedarone hydrochloride by spray drying

Matija Gretić; Gordana Matijašić; Juraj Petanjek


Dublin Core Export

<?xml version='1.0' encoding='utf-8'?>
<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Matija Gretić</dc:creator>
  <dc:creator>Gordana Matijašić</dc:creator>
  <dc:creator>Juraj Petanjek</dc:creator>
  <dc:date>2020-09-30</dc:date>
  <dc:description>Microencapsulation is a method often used in various industries and one of the many advantages is that controlled release of the active ingredient can be achieved. The aim of this study was to prepare microcapsules by spray drying by changing the process conditions and ratios of the used components, polymer excipient poly(vinyl alcohol) and active ingredient dronedarone hydrochloride. Dosage forms of poly(vinyl alcohol) and dronedarone hydrochloride were prepared in 1:1, 2:1 and 3:1 weight ratios and the solutions were dried in a laboratory spray dryer at four different atomization flowrates. The morphology of the obtained microcapsules was examined using a scanning electron microscope (SEM). The release kinetics of the active ingredient from the microcapsules were examined by in vitro laboratory testing and the resulting release profiles were described using the Weibull model. The results showed that the change of weight ratio has influence on the morphology of microcapsules, the efficiency of microencapsulation and drug release.</dc:description>
  <dc:identifier>https://zenodo.org/record/4059842</dc:identifier>
  <dc:identifier>10.5281/zenodo.4059842</dc:identifier>
  <dc:identifier>oai:zenodo.org:4059842</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>doi:10.5281/zenodo.4059841</dc:relation>
  <dc:relation>url:https://zenodo.org/communities/ta</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>https://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
  <dc:source>Technologica Acta 13(1) 1-8</dc:source>
  <dc:subject>microencapsulation, spray drying, dronedarone hydrochloride, poly(vinyl alcohol), in vitro drug release</dc:subject>
  <dc:title>Microencapsulation of dronedarone hydrochloride by spray drying</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>
54
10
views
downloads
All versions This version
Views 5454
Downloads 1010
Data volume 19.0 MB19.0 MB
Unique views 4949
Unique downloads 99

Share

Cite as