4018962
doi
10.5281/zenodo.4018962
oai:zenodo.org:4018962
Bodrug, Nicolae
Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
Istrate, Viorel
Medical Center "Excellence", Chisinau, the Republic of Moldova
Precancerous gastric lesions: pathophysiology and symptomatology
Botezatu, Adriana
Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
gastric intestinal metaplasia
epithelial dysplasia
gastric cancer
Helicobacter pylori
<p><strong>Background</strong>: Independent risk factors for chronic atrophic gastritis, gastric intestinal metaplasia and gastric cancer are: Helicobacter pylori infection (especially virulent CagA strains), genetic factors (advanced age, reflecting the duration of Helicobacter pylori infection, male gender, family history of gastric cancer in first-degree relatives), gastric ulcer, biliary reflux, acute or chronic gastric inflammation, smoking, alcohol consumption, prolonged use of proton pump inhibitors or non-steroidal anti-inflammatory drugs, diet low in fruits, vegetables and vitamin C, excessive salt intake and consumption of canned foods with salt). Helicobacter pylori infection and inflammatory cells induce the expression of inducible nitric oxide synthase in the gastroduodenal mucosa, which causes various clinical lesions (duodenal ulcer, gastric ulcer and chronic gastritis without ulcer). Another important condition associated with Helicobacter pylori infection is gastric cancer. Overproduction of nitric oxide, through inducible nitric oxide synthase and oxidative stress, is a genotoxic and mutagenic metabolism which plays a crucial role in the process of gastric carcinogenesis.</p>
<p><strong>Conclusions: </strong>Chronic atrophic gastritis is considered a multifaceted condition because it can manifest itself through a variable spectrum of nonspecific gastric and extra-gastric symptoms, with an overlap of the clinical features of the two entities of chronic atrophic gastritis – autoimmune and associated with Helicobacter pylori infection. Thus, in contrast to the classic perception of a silent condition, patients with chronic atrophic gastritis report a wide range of gastrointestinal symptoms, ranging from dyspeptic symptoms to those of gastroesophageal reflux.</p>
Zenodo
2020-11-01
info:eu-repo/semantics/article
4018961
1601512010.698694
1393521
md5:19f2d7a12f2b49868ba1c727368caabf
https://zenodo.org/records/4018962/files/MMJ-2020-63-5_62-67.pdf
public
10.5281/zenodo.4018961
isVersionOf
doi
Moldovan Medical Journal
63(5)
62-67
2020-11-01