Leahu, Pavel
Groppa, Stanislav
2020-11-01
<p><strong>Background: </strong> Nowadays, neuro-modulation offers different devices and techniques in the treatment of neurological patients suffering from paroxysmal disorders, such as epilepsy and migraine. Among non-pharmacologic therapies, rTMS shows good results. </p>
<p><strong>Material and methods: </strong>A longitudinal, double-blinded, rTMS-intervention study was conducted on 42 subjects with episodic migraine (with and without aura, 2-14 attacks per month). After a baseline follow-up for 1 month, subjects had 6 sessions of rTMS during 2 weeks and received multifocal rTMS or sham stimulation, with further 3-month assessment via questionnaires on headache frequency .</p>
<p><strong>Results:</strong> After stimulation, the real rTMS group showed a reduction in the number of attacks – 7.5 ± 3.7 at baseline to 3.8 ± 2.7 attacks at 3 months’ period (p0.05). There was a significant reduction in the intensity of attacks over 4-week therapy in the treatment group (6.7 ± 1.5 at baseline; 5.3 ± 2.5 at 4 weeks (p<0.05). The conducted questionnaires revealed a positive impact on quality of life and functional outcomes. There were no serious adverse events reported. </p>
<p><strong>Conclusions: </strong>Our study showed evidence that the experimental rTMS protocol significantly reduced the frequency and intensity of migraine attacks compared to placebo treatment with no serious adverse events.</p>
https://doi.org/10.5281/zenodo.4018912
oai:zenodo.org:4018912
eng
Zenodo
https://doi.org/10.5281/zenodo.4018911
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Moldovan Medical Journal, 63(5), 26-29, (2020-11-01)
transcranial magnetic stimulation
multifocal
migraine
Neuromodulatory approach in paroxysmal neurological disorders
info:eu-repo/semantics/article