Journal article Open Access

Functional features in interstitial lung diseases

Calaras, Diana; Rusu, Doina; David, Aliona; Botnaru, Victor


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    <subfield code="a">&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Interstitial lung diseases (ILD) are a group of disorders that are generally thought to commonly share a restrictive ventilatory defect and reduced diffusing capacity for carbon monoxide (DLCO). The aim was to find distinctive features of the pulmonary function tests (PFT) results in different types of ILD.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Material and methods:&lt;/strong&gt; We conducted a retrospective study of 40 consecutive patients with ILD admitted to the Institute of Pthisiopneumology, Chisinau, the Republic of Moldova, during January 2019 &amp;ndash; February 2020. The cohort included 10 cases of sarcoidosis patients, 8 cases of idiopathic pulmonary fibrosis (IPF) patients, 7 patients with nonspecific idiopathic interstitial pneumonia, 9 cases with hypersensitivity pneumonitis (HP) and 6 histiocytosis cases. All patients have been evaluated by pulmonary function tests (PFT), 6 minutes walk test, Medical Research Council scale for dyspnea, etc.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Overall, we found normal mean spirometry parameters, a slightly increased mean residual volume (127.5&amp;plusmn;42.1), a mildly decreased mean total lung capacity (88.8&amp;plusmn;22.3) and moderately reduced DLCO (52.6&amp;plusmn;21.5). We found a dominant restrictive pattern in 75% of patients, and obstruction only in 7.5% when we used spirometry parameters. When we applied the bodyplethismographic values, we have found that an air-trapping pattern was identified in 32.5% cases of patients. This pattern has been identified in 1/3 of HP patients and in 10% of sarcoidosis patients.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; PFT can help identifying individual features of different types of ILD being able to show even obstructive changes in a group of diseases thought to be strictly restrictive.&lt;/p&gt;</subfield>
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