4018896
doi
10.5281/zenodo.4018896
oai:zenodo.org:4018896
Rusu, Doina
Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
David, Aliona
2 Chiril Draganiuc Institute of Phthisiopneumology, Chisinau, the Republic of Moldova
Botnaru, Victor
Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
Functional features in interstitial lung diseases
Calaras, Diana
Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
interstitial lung diseases
pulmonary function tests
obstruction
restriction
<p><strong>Background: </strong>Interstitial lung diseases (ILD) are a group of disorders that are generally thought to commonly share a restrictive ventilatory defect and reduced diffusing capacity for carbon monoxide (DLCO). The aim was to find distinctive features of the pulmonary function tests (PFT) results in different types of ILD.</p>
<p><strong>Material and methods:</strong> We conducted a retrospective study of 40 consecutive patients with ILD admitted to the Institute of Pthisiopneumology, Chisinau, the Republic of Moldova, during January 2019 – February 2020. The cohort included 10 cases of sarcoidosis patients, 8 cases of idiopathic pulmonary fibrosis (IPF) patients, 7 patients with nonspecific idiopathic interstitial pneumonia, 9 cases with hypersensitivity pneumonitis (HP) and 6 histiocytosis cases. All patients have been evaluated by pulmonary function tests (PFT), 6 minutes walk test, Medical Research Council scale for dyspnea, etc.</p>
<p><strong>Results: </strong>Overall, we found normal mean spirometry parameters, a slightly increased mean residual volume (127.5±42.1), a mildly decreased mean total lung capacity (88.8±22.3) and moderately reduced DLCO (52.6±21.5). We found a dominant restrictive pattern in 75% of patients, and obstruction only in 7.5% when we used spirometry parameters. When we applied the bodyplethismographic values, we have found that an air-trapping pattern was identified in 32.5% cases of patients. This pattern has been identified in 1/3 of HP patients and in 10% of sarcoidosis patients.</p>
<p><strong>Conclusions:</strong> PFT can help identifying individual features of different types of ILD being able to show even obstructive changes in a group of diseases thought to be strictly restrictive.</p>
Zenodo
2020-11-01
info:eu-repo/semantics/article
4018895
1601512010.634496
1752542
md5:34995b6be432d1e7efcf2a7fcc1f4fc5
https://zenodo.org/records/4018896/files/MMJ-2020-63-5_9-14.pdf
public
10.5281/zenodo.4018895
isVersionOf
doi
Moldovan Medical Journal
63(5)
9-14
2020-11-01