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Functional features in interstitial lung diseases

Calaras, Diana; Rusu, Doina; David, Aliona; Botnaru, Victor


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    "description": "<p><strong>Background: </strong>Interstitial lung diseases (ILD) are a group of disorders that are generally thought to commonly share a restrictive ventilatory defect and reduced diffusing capacity for carbon monoxide (DLCO). The aim was to find distinctive features of the pulmonary function tests (PFT) results in different types of ILD.</p>\n\n<p><strong>Material and methods:</strong> We conducted a retrospective study of 40 consecutive patients with ILD admitted to the Institute of Pthisiopneumology, Chisinau, the Republic of Moldova, during January 2019 &ndash; February 2020. The cohort included 10 cases of sarcoidosis patients, 8 cases of idiopathic pulmonary fibrosis (IPF) patients, 7 patients with nonspecific idiopathic interstitial pneumonia, 9 cases with hypersensitivity pneumonitis (HP) and 6 histiocytosis cases. All patients have been evaluated by pulmonary function tests (PFT), 6 minutes walk test, Medical Research Council scale for dyspnea, etc.</p>\n\n<p><strong>Results: </strong>Overall, we found normal mean spirometry parameters, a slightly increased mean residual volume (127.5&plusmn;42.1), a mildly decreased mean total lung capacity (88.8&plusmn;22.3) and moderately reduced DLCO (52.6&plusmn;21.5). We found a dominant restrictive pattern in 75% of patients, and obstruction only in 7.5% when we used spirometry parameters. When we applied the bodyplethismographic values, we have found that an air-trapping pattern was identified in 32.5% cases of patients. This pattern has been identified in 1/3 of HP patients and in 10% of sarcoidosis patients.</p>\n\n<p><strong>Conclusions:</strong> PFT can help identifying individual features of different types of ILD being able to show even obstructive changes in a group of diseases thought to be strictly restrictive.</p>", 
    "language": "eng", 
    "title": "Functional features in interstitial lung diseases", 
    "license": {
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    "journal": {
      "volume": "63(5)", 
      "pages": "9-14", 
      "title": "Moldovan Medical Journal"
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    "keywords": [
      "interstitial lung diseases", 
      "pulmonary function tests", 
      "obstruction", 
      "restriction"
    ], 
    "publication_date": "2020-11-01", 
    "creators": [
      {
        "orcid": "0000-0002-8963-459X", 
        "affiliation": "Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova", 
        "name": "Calaras, Diana"
      }, 
      {
        "orcid": "0000-0003-3029-5025", 
        "affiliation": "Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova", 
        "name": "Rusu, Doina"
      }, 
      {
        "orcid": "0000-0002-7143-6800", 
        "affiliation": "2 Chiril Draganiuc Institute of Phthisiopneumology, Chisinau, the Republic of Moldova", 
        "name": "David, Aliona"
      }, 
      {
        "orcid": "0000-0002-0863-5268", 
        "affiliation": "Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova", 
        "name": "Botnaru, Victor"
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