Journal article Open Access

Functional features in interstitial lung diseases

Calaras, Diana; Rusu, Doina; David, Aliona; Botnaru, Victor


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  <identifier identifierType="DOI">10.5281/zenodo.4018896</identifier>
  <creators>
    <creator>
      <creatorName>Calaras, Diana</creatorName>
      <givenName>Diana</givenName>
      <familyName>Calaras</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-8963-459X</nameIdentifier>
      <affiliation>Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova</affiliation>
    </creator>
    <creator>
      <creatorName>Rusu, Doina</creatorName>
      <givenName>Doina</givenName>
      <familyName>Rusu</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-3029-5025</nameIdentifier>
      <affiliation>Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova</affiliation>
    </creator>
    <creator>
      <creatorName>David, Aliona</creatorName>
      <givenName>Aliona</givenName>
      <familyName>David</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-7143-6800</nameIdentifier>
      <affiliation>2 Chiril Draganiuc Institute of Phthisiopneumology, Chisinau, the Republic of Moldova</affiliation>
    </creator>
    <creator>
      <creatorName>Botnaru, Victor</creatorName>
      <givenName>Victor</givenName>
      <familyName>Botnaru</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-0863-5268</nameIdentifier>
      <affiliation>Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Functional features in interstitial lung diseases</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2020</publicationYear>
  <subjects>
    <subject>interstitial lung diseases</subject>
    <subject>pulmonary function tests</subject>
    <subject>obstruction</subject>
    <subject>restriction</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2020-11-01</date>
  </dates>
  <language>en</language>
  <resourceType resourceTypeGeneral="JournalArticle"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/4018896</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.4018895</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Interstitial lung diseases (ILD) are a group of disorders that are generally thought to commonly share a restrictive ventilatory defect and reduced diffusing capacity for carbon monoxide (DLCO). The aim was to find distinctive features of the pulmonary function tests (PFT) results in different types of ILD.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Material and methods:&lt;/strong&gt; We conducted a retrospective study of 40 consecutive patients with ILD admitted to the Institute of Pthisiopneumology, Chisinau, the Republic of Moldova, during January 2019 &amp;ndash; February 2020. The cohort included 10 cases of sarcoidosis patients, 8 cases of idiopathic pulmonary fibrosis (IPF) patients, 7 patients with nonspecific idiopathic interstitial pneumonia, 9 cases with hypersensitivity pneumonitis (HP) and 6 histiocytosis cases. All patients have been evaluated by pulmonary function tests (PFT), 6 minutes walk test, Medical Research Council scale for dyspnea, etc.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Overall, we found normal mean spirometry parameters, a slightly increased mean residual volume (127.5&amp;plusmn;42.1), a mildly decreased mean total lung capacity (88.8&amp;plusmn;22.3) and moderately reduced DLCO (52.6&amp;plusmn;21.5). We found a dominant restrictive pattern in 75% of patients, and obstruction only in 7.5% when we used spirometry parameters. When we applied the bodyplethismographic values, we have found that an air-trapping pattern was identified in 32.5% cases of patients. This pattern has been identified in 1/3 of HP patients and in 10% of sarcoidosis patients.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; PFT can help identifying individual features of different types of ILD being able to show even obstructive changes in a group of diseases thought to be strictly restrictive.&lt;/p&gt;</description>
  </descriptions>
</resource>
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