4016808
doi
10.5281/zenodo.4016808
oai:zenodo.org:4016808
Globa, Lilian
Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
David, Valeriu
Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
Globa, Pavel
Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
Pelin, Elina
Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
Saptefrati, Lilian
Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
Macrophages and dendritic cells density correlates with depth of invasion in the prostate carcinoma
Globa, Tatiana
Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
prostate cancer
dendritic cells
<p><strong>Background:</strong> Immune cells interact not only with tumor cells but also with stromal cells facilitating the progression of neoplasia. The ongoing battle between immune cells and the tumor is an important factor influencing the clinical course and outcome of treatment in various types of cancer. The aim of the study was to identify the prognostic value of dendritic cells and macrophages in prostate carcinoma.</p>
<p><strong>Material and methods:</strong> This retrospective study analyzed 73 samples of prostate cancer. The macrophages and dendritic cells have been evaluated using the immunohistochemical methods with CD68 (macrophages) and S100 (dendritic cells). Macrophages were quantified as intratumoral and peritumoral, and dendritic cells – intraepithelial and stromal. The results were analyzed statistically.</p>
<p><strong>Results:</strong> For evaluation of the prognostic impact of immune cells was accomplished a correlation between the total number of CD68+/S100+ cells and the Gleason score. Thus, statistically significant correlations were obtained both for CD68+ cells (intratumoral p=0.008, peritumoral p=0.001), and for S100+ cells (intraepithelial p=0.036, stromal p=0.042). In addition, a statistically significant positive linear correlation was observed between the density of intraepithelial S100+ cells and intratumoral CD68+ cells (p=0.018).</p>
<p><strong>Conclusions: </strong>The increase in the density of S100+ and CD68+ cells, as well as the significant association of their density with the histological degree of the tumor allow us to consider these cells as predictive biomarkers in prostate carcinomas.</p>
Zenodo
2020-10-01
info:eu-repo/semantics/article
4016807
1600477171.96201
4657089
md5:5dd81783920840b66a4efec4df988751
https://zenodo.org/records/4016808/files/MMJ-Vol-63-No-4-Oct-2020_27-34.pdf
public
10.5281/zenodo.4016807
isVersionOf
doi
Moldovan Medical Journal
63(4)
27-34
2020-10-01