Journal article Closed Access

Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.

van der Aart, Jasper; van der Doef, Thalia F; Horstman, Paul; Huisman, Marc C; Schuit, Robert C; van Lingen, Arthur; Windhorst, Albert D; van Berckel, Bart,NM; Lammerstma, Adriaan A


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    <subfield code="c">1330-1333</subfield>
    <subfield code="n">8</subfield>
    <subfield code="p">Journal of Nuclear Medicine</subfield>
    <subfield code="v">58</subfield>
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    <subfield code="a">&lt;p&gt;The methylguanadine derivative [&lt;sup&gt;11&lt;/sup&gt;C]GMOM has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the [&lt;sup&gt;11&lt;/sup&gt;C]GMOM radiation dose in healthy humans.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Methods:&lt;/strong&gt; Following [&lt;sup&gt;11&lt;/sup&gt;C]GMOM injection, three female and two male subjects underwent 10 consecutive whole body PET scans in approximately 77 minutes. 7 source organs were defined manually, scaled to a gender specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue weighting factors (ICRP103) were used to calculate the effective dose.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Results:&lt;/strong&gt; Absorbed radiation doses in source organs ranged from 7.7 &amp;micro;Gy&amp;middot;MBq&lt;sup&gt;-1&lt;/sup&gt; in the brain to 12.7 &amp;micro;Gy&amp;middot;MBq&lt;sup&gt;-1&lt;/sup&gt; in the spleen. The effective dose (&amp;plusmn;SD) was 4.5 &amp;plusmn; 0.5 &amp;micro;Sv&amp;middot;MBq&lt;sup&gt;-1&lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; The effective dose of [&lt;sup&gt;11&lt;/sup&gt;C]GMOM is at the lower end of the range seen for other C-11 labelled ligands, allowing for serial PET scanning in a single subject.&lt;/p&gt;</subfield>
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    <subfield code="u">Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
    <subfield code="a">van der Doef, Thalia F</subfield>
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    <subfield code="u">Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
    <subfield code="a">Horstman, Paul</subfield>
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    <subfield code="u">Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
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    <subfield code="u">Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
    <subfield code="a">Schuit, Robert C</subfield>
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    <subfield code="u">Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
    <subfield code="a">van Lingen, Arthur</subfield>
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    <subfield code="u">Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
    <subfield code="a">Windhorst, Albert D</subfield>
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    <subfield code="u">Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
    <subfield code="a">van Berckel, Bart,NM</subfield>
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    <subfield code="u">Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
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    <subfield code="u">Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
    <subfield code="a">van der Aart, Jasper</subfield>
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    <subfield code="a">11C</subfield>
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    <subfield code="a">Dosimetry</subfield>
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    <subfield code="a">NMDA</subfield>
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    <subfield code="a">Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.</subfield>
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