Journal article Closed Access
van der Aart, Jasper; van der Doef, Thalia F; Horstman, Paul; Huisman, Marc C; Schuit, Robert C; van Lingen, Arthur; Windhorst, Albert D; van Berckel, Bart,NM; Lammerstma, Adriaan A
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2017-02-09</subfield> </datafield> <controlfield tag="005">20200120170533.0</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-ecfunded</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-inmind</subfield> </datafield> <controlfield tag="001">400829</controlfield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="p">openaire</subfield> <subfield code="p">user-ecfunded</subfield> <subfield code="p">user-inmind</subfield> <subfield code="o">oai:zenodo.org:400829</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="c">1330-1333</subfield> <subfield code="n">8</subfield> <subfield code="p">Journal of Nuclear Medicine</subfield> <subfield code="v">58</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a"><p>The methylguanadine derivative [<sup>11</sup>C]GMOM has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the [<sup>11</sup>C]GMOM radiation dose in healthy humans.</p> <p><strong>Methods:</strong> Following [<sup>11</sup>C]GMOM injection, three female and two male subjects underwent 10 consecutive whole body PET scans in approximately 77 minutes. 7 source organs were defined manually, scaled to a gender specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue weighting factors (ICRP103) were used to calculate the effective dose.</p> <p><strong>Results:</strong> Absorbed radiation doses in source organs ranged from 7.7 &micro;Gy&middot;MBq<sup>-1</sup> in the brain to 12.7 &micro;Gy&middot;MBq<sup>-1</sup> in the spleen. The effective dose (&plusmn;SD) was 4.5 &plusmn; 0.5 &micro;Sv&middot;MBq<sup>-1</sup></p> <p><strong>Conclusion:</strong> The effective dose of [<sup>11</sup>C]GMOM is at the lower end of the range seen for other C-11 labelled ligands, allowing for serial PET scanning in a single subject.</p></subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield> <subfield code="a">van der Doef, Thalia F</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield> <subfield code="a">Horstman, Paul</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield> <subfield code="a">Huisman, Marc C</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield> <subfield code="a">Schuit, Robert C</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield> <subfield code="a">van Lingen, Arthur</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield> <subfield code="a">Windhorst, Albert D</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield> <subfield code="a">van Berckel, Bart,NM</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield> <subfield code="a">Lammerstma, Adriaan A</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">closed</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">article</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield> <subfield code="a">van der Aart, Jasper</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">11C</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Dosimetry</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">NMDA</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Neurology</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">PET</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">PET/CT</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Radiobiology/Dosimetry</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.2967/jnumed.116.188250</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.</subfield> </datafield> <datafield tag="536" ind1=" " ind2=" "> <subfield code="c">278850</subfield> <subfield code="a">Imaging of Neuroinflammation in Neurodegenerative Diseases</subfield> </datafield> </record>
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