Journal article Closed Access
Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.
van der Aart, Jasper; van der Doef, Thalia F; Horstman, Paul; Huisman, Marc C; Schuit, Robert C; van Lingen, Arthur; Windhorst, Albert D; van Berckel, Bart,NM; Lammerstma, Adriaan A
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<subfield code="c">1330-1333</subfield>
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<subfield code="p">Journal of Nuclear Medicine</subfield>
<subfield code="v">58</subfield>
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<subfield code="a"><p>The methylguanadine derivative [<sup>11</sup>C]GMOM has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the [<sup>11</sup>C]GMOM radiation dose in healthy humans.</p>
<p><strong>Methods:</strong> Following [<sup>11</sup>C]GMOM injection, three female and two male subjects underwent 10 consecutive whole body PET scans in approximately 77 minutes. 7 source organs were defined manually, scaled to a gender specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue weighting factors (ICRP103) were used to calculate the effective dose.</p>
<p><strong>Results:</strong> Absorbed radiation doses in source organs ranged from 7.7 &micro;Gy&middot;MBq<sup>-1</sup> in the brain to 12.7 &micro;Gy&middot;MBq<sup>-1</sup> in the spleen. The effective dose (&plusmn;SD) was 4.5 &plusmn; 0.5 &micro;Sv&middot;MBq<sup>-1</sup></p>
<p><strong>Conclusion:</strong> The effective dose of [<sup>11</sup>C]GMOM is at the lower end of the range seen for other C-11 labelled ligands, allowing for serial PET scanning in a single subject.</p></subfield>
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<subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
<subfield code="a">van der Doef, Thalia F</subfield>
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<subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
<subfield code="a">Horstman, Paul</subfield>
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<subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
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<subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
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<subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
<subfield code="a">van Lingen, Arthur</subfield>
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<subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
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<subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
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<subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
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<subfield code="u">Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</subfield>
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<subfield code="a">11C</subfield>
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<subfield code="a">Dosimetry</subfield>
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<subfield code="a">NMDA</subfield>
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<subfield code="a">Neurology</subfield>
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<subfield code="a">PET</subfield>
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<subfield code="a">Radiobiology/Dosimetry</subfield>
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<subfield code="a">10.2967/jnumed.116.188250</subfield>
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<subfield code="a">Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.</subfield>
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<subfield code="a">Imaging of Neuroinflammation in Neurodegenerative Diseases</subfield>
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