Journal article Closed Access

Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.

van der Aart, Jasper; van der Doef, Thalia F; Horstman, Paul; Huisman, Marc C; Schuit, Robert C; van Lingen, Arthur; Windhorst, Albert D; van Berckel, Bart,NM; Lammerstma, Adriaan A


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  "doi": "10.2967/jnumed.116.188250", 
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    "latest_html": "https://zenodo.org/record/400829", 
    "doi": "https://doi.org/10.2967/jnumed.116.188250", 
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  "created": "2017-03-20T08:01:41.750982+00:00", 
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  "revision": 6, 
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  "metadata": {
    "access_right_category": "danger", 
    "doi": "10.2967/jnumed.116.188250", 
    "description": "<p>The methylguanadine derivative [<sup>11</sup>C]GMOM has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the [<sup>11</sup>C]GMOM radiation dose in healthy humans.</p>\n\n<p><strong>Methods:</strong> Following [<sup>11</sup>C]GMOM injection, three female and two male subjects underwent 10 consecutive whole body PET scans in approximately 77 minutes. 7 source organs were defined manually, scaled to a gender specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue weighting factors (ICRP103) were used to calculate the effective dose.</p>\n\n<p><strong>Results:</strong> Absorbed radiation doses in source organs ranged from 7.7 &micro;Gy&middot;MBq<sup>-1</sup> in the brain to 12.7 &micro;Gy&middot;MBq<sup>-1</sup> in the spleen. The effective dose (&plusmn;SD) was 4.5 &plusmn; 0.5 &micro;Sv&middot;MBq<sup>-1</sup></p>\n\n<p><strong>Conclusion:</strong> The effective dose of [<sup>11</sup>C]GMOM is at the lower end of the range seen for other C-11 labelled ligands, allowing for serial PET scanning in a single subject.</p>", 
    "title": "Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.", 
    "journal": {
      "volume": "58", 
      "issue": "8", 
      "pages": "1330-1333", 
      "title": "Journal of Nuclear Medicine"
    }, 
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    "communities": [
      {
        "id": "ecfunded"
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    "grants": [
      {
        "code": "278850", 
        "links": {
          "self": "https://zenodo.org/api/grants/10.13039/501100000780::278850"
        }, 
        "title": "Imaging of Neuroinflammation in Neurodegenerative Diseases", 
        "acronym": "INMIND", 
        "program": "FP7", 
        "funder": {
          "doi": "10.13039/501100000780", 
          "acronyms": [
            "EC"
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          "name": "European Commission", 
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    "keywords": [
      "11C", 
      "Dosimetry", 
      "NMDA", 
      "Neurology", 
      "PET", 
      "PET/CT", 
      "Radiobiology/Dosimetry"
    ], 
    "publication_date": "2017-02-09", 
    "creators": [
      {
        "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", 
        "name": "van der Aart, Jasper"
      }, 
      {
        "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", 
        "name": "van der Doef, Thalia F"
      }, 
      {
        "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", 
        "name": "Horstman, Paul"
      }, 
      {
        "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", 
        "name": "Huisman, Marc C"
      }, 
      {
        "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", 
        "name": "Schuit, Robert C"
      }, 
      {
        "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", 
        "name": "van Lingen, Arthur"
      }, 
      {
        "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", 
        "name": "Windhorst, Albert D"
      }, 
      {
        "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", 
        "name": "van Berckel, Bart,NM"
      }, 
      {
        "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", 
        "name": "Lammerstma, Adriaan A"
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    ], 
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