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van der Aart, Jasper; van der Doef, Thalia F; Horstman, Paul; Huisman, Marc C; Schuit, Robert C; van Lingen, Arthur; Windhorst, Albert D; van Berckel, Bart,NM; Lammerstma, Adriaan A
{ "owners": [ 1964 ], "doi": "10.2967/jnumed.116.188250", "stats": { "version_unique_downloads": 0.0, "unique_views": 59.0, "views": 61.0, "version_views": 61.0, "unique_downloads": 0.0, "version_unique_views": 59.0, "volume": 0.0, "version_downloads": 0.0, "downloads": 0.0, "version_volume": 0.0 }, "links": { "latest_html": "https://zenodo.org/record/400829", "doi": "https://doi.org/10.2967/jnumed.116.188250", "badge": "https://zenodo.org/badge/doi/10.2967/jnumed.116.188250.svg", "html": "https://zenodo.org/record/400829", "latest": "https://zenodo.org/api/records/400829" }, "created": "2017-03-20T08:01:41.750982+00:00", "updated": "2020-01-20T17:05:33.510856+00:00", "conceptrecid": "791778", "revision": 8, "id": 400829, "metadata": { "access_right_category": "danger", "doi": "10.2967/jnumed.116.188250", "description": "<p>The methylguanadine derivative [<sup>11</sup>C]GMOM has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the [<sup>11</sup>C]GMOM radiation dose in healthy humans.</p>\n\n<p><strong>Methods:</strong> Following [<sup>11</sup>C]GMOM injection, three female and two male subjects underwent 10 consecutive whole body PET scans in approximately 77 minutes. 7 source organs were defined manually, scaled to a gender specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue weighting factors (ICRP103) were used to calculate the effective dose.</p>\n\n<p><strong>Results:</strong> Absorbed radiation doses in source organs ranged from 7.7 µGy·MBq<sup>-1</sup> in the brain to 12.7 µGy·MBq<sup>-1</sup> in the spleen. The effective dose (±SD) was 4.5 ± 0.5 µSv·MBq<sup>-1</sup></p>\n\n<p><strong>Conclusion:</strong> The effective dose of [<sup>11</sup>C]GMOM is at the lower end of the range seen for other C-11 labelled ligands, allowing for serial PET scanning in a single subject.</p>", "title": "Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.", "journal": { "volume": "58", "issue": "8", "pages": "1330-1333", "title": "Journal of Nuclear Medicine" }, "relations": { "version": [ { "count": 1, "index": 0, "parent": { "pid_type": "recid", "pid_value": "791778" }, "is_last": true, "last_child": { "pid_type": "recid", "pid_value": "400829" } } ] }, "communities": [ { "id": "ecfunded" }, { "id": "inmind" } ], "grants": [ { "code": "278850", "links": { "self": "https://zenodo.org/api/grants/10.13039/501100000780::278850" }, "title": "Imaging of Neuroinflammation in Neurodegenerative Diseases", "acronym": "INMIND", "program": "FP7", "funder": { "doi": "10.13039/501100000780", "acronyms": [], "name": "European Commission", "links": { "self": "https://zenodo.org/api/funders/10.13039/501100000780" } } } ], "keywords": [ "11C", "Dosimetry", "NMDA", "Neurology", "PET", "PET/CT", "Radiobiology/Dosimetry" ], "publication_date": "2017-02-09", "creators": [ { "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", "name": "van der Aart, Jasper" }, { "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", "name": "van der Doef, Thalia F" }, { "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", "name": "Horstman, Paul" }, { "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", "name": "Huisman, Marc C" }, { "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", "name": "Schuit, Robert C" }, { "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", "name": "van Lingen, Arthur" }, { "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", "name": "Windhorst, Albert D" }, { "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", "name": "van Berckel, Bart,NM" }, { "affiliation": "Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands", "name": "Lammerstma, Adriaan A" } ], "access_right": "closed", "resource_type": { "subtype": "article", "type": "publication", "title": "Journal article" } } }
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