Journal article Closed Access

Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.

van der Aart, Jasper; van der Doef, Thalia F; Horstman, Paul; Huisman, Marc C; Schuit, Robert C; van Lingen, Arthur; Windhorst, Albert D; van Berckel, Bart,NM; Lammerstma, Adriaan A


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  <identifier identifierType="URL">https://zenodo.org/record/400829</identifier>
  <creators>
    <creator>
      <creatorName>van der Aart, Jasper</creatorName>
      <givenName>Jasper</givenName>
      <familyName>van der Aart</familyName>
      <affiliation>Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>van der Doef, Thalia F</creatorName>
      <givenName>Thalia F</givenName>
      <familyName>van der Doef</familyName>
      <affiliation>Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>Horstman, Paul</creatorName>
      <givenName>Paul</givenName>
      <familyName>Horstman</familyName>
      <affiliation>Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>Huisman, Marc C</creatorName>
      <givenName>Marc C</givenName>
      <familyName>Huisman</familyName>
      <affiliation>Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>Schuit, Robert C</creatorName>
      <givenName>Robert C</givenName>
      <familyName>Schuit</familyName>
      <affiliation>Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>van Lingen, Arthur</creatorName>
      <givenName>Arthur</givenName>
      <familyName>van Lingen</familyName>
      <affiliation>Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>Windhorst, Albert D</creatorName>
      <givenName>Albert D</givenName>
      <familyName>Windhorst</familyName>
      <affiliation>Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>van Berckel, Bart,NM</creatorName>
      <affiliation>Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</affiliation>
    </creator>
    <creator>
      <creatorName>Lammerstma, Adriaan A</creatorName>
      <givenName>Adriaan A</givenName>
      <familyName>Lammerstma</familyName>
      <affiliation>Department of Radiology &amp; Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2017</publicationYear>
  <subjects>
    <subject>11C</subject>
    <subject>Dosimetry</subject>
    <subject>NMDA</subject>
    <subject>Neurology</subject>
    <subject>PET</subject>
    <subject>PET/CT</subject>
    <subject>Radiobiology/Dosimetry</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2017-02-09</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/400829</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.2967/jnumed.116.188250</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/ecfunded</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/inmind</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="info:eu-repo/semantics/closedAccess">Closed Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;The methylguanadine derivative [&lt;sup&gt;11&lt;/sup&gt;C]GMOM has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the [&lt;sup&gt;11&lt;/sup&gt;C]GMOM radiation dose in healthy humans.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Methods:&lt;/strong&gt; Following [&lt;sup&gt;11&lt;/sup&gt;C]GMOM injection, three female and two male subjects underwent 10 consecutive whole body PET scans in approximately 77 minutes. 7 source organs were defined manually, scaled to a gender specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue weighting factors (ICRP103) were used to calculate the effective dose.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Results:&lt;/strong&gt; Absorbed radiation doses in source organs ranged from 7.7 &amp;micro;Gy&amp;middot;MBq&lt;sup&gt;-1&lt;/sup&gt; in the brain to 12.7 &amp;micro;Gy&amp;middot;MBq&lt;sup&gt;-1&lt;/sup&gt; in the spleen. The effective dose (&amp;plusmn;SD) was 4.5 &amp;plusmn; 0.5 &amp;micro;Sv&amp;middot;MBq&lt;sup&gt;-1&lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; The effective dose of [&lt;sup&gt;11&lt;/sup&gt;C]GMOM is at the lower end of the range seen for other C-11 labelled ligands, allowing for serial PET scanning in a single subject.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/FP7/278850/">278850</awardNumber>
      <awardTitle>Imaging of Neuroinflammation in Neurodegenerative Diseases</awardTitle>
    </fundingReference>
  </fundingReferences>
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