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Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.

van der Aart, Jasper; van der Doef, Thalia F; Horstman, Paul; Huisman, Marc C; Schuit, Robert C; van Lingen, Arthur; Windhorst, Albert D; van Berckel, Bart,NM; Lammerstma, Adriaan A


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{
  "DOI": "10.2967/jnumed.116.188250", 
  "container_title": "Journal of Nuclear Medicine", 
  "title": "Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.", 
  "issued": {
    "date-parts": [
      [
        2017, 
        2, 
        9
      ]
    ]
  }, 
  "abstract": "<p>The methylguanadine derivative [<sup>11</sup>C]GMOM has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the [<sup>11</sup>C]GMOM radiation dose in healthy humans.</p>\n\n<p><strong>Methods:</strong> Following [<sup>11</sup>C]GMOM injection, three female and two male subjects underwent 10 consecutive whole body PET scans in approximately 77 minutes. 7 source organs were defined manually, scaled to a gender specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue weighting factors (ICRP103) were used to calculate the effective dose.</p>\n\n<p><strong>Results:</strong> Absorbed radiation doses in source organs ranged from 7.7 &micro;Gy&middot;MBq<sup>-1</sup> in the brain to 12.7 &micro;Gy&middot;MBq<sup>-1</sup> in the spleen. The effective dose (&plusmn;SD) was 4.5 &plusmn; 0.5 &micro;Sv&middot;MBq<sup>-1</sup></p>\n\n<p><strong>Conclusion:</strong> The effective dose of [<sup>11</sup>C]GMOM is at the lower end of the range seen for other C-11 labelled ligands, allowing for serial PET scanning in a single subject.</p>", 
  "author": [
    {
      "family": "van der Aart, Jasper"
    }, 
    {
      "family": "van der Doef, Thalia F"
    }, 
    {
      "family": "Horstman, Paul"
    }, 
    {
      "family": "Huisman, Marc C"
    }, 
    {
      "family": "Schuit, Robert C"
    }, 
    {
      "family": "van Lingen, Arthur"
    }, 
    {
      "family": "Windhorst, Albert D"
    }, 
    {
      "family": "van Berckel, Bart,NM"
    }, 
    {
      "family": "Lammerstma, Adriaan A"
    }
  ], 
  "page": "1330-1333", 
  "volume": "58", 
  "type": "article-journal", 
  "issue": "8", 
  "id": "400829"
}
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