Journal article Closed Access
van der Aart, Jasper; van der Doef, Thalia F; Horstman, Paul; Huisman, Marc C; Schuit, Robert C; van Lingen, Arthur; Windhorst, Albert D; van Berckel, Bart,NM; Lammerstma, Adriaan A
{ "DOI": "10.2967/jnumed.116.188250", "container_title": "Journal of Nuclear Medicine", "title": "Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.", "issued": { "date-parts": [ [ 2017, 2, 9 ] ] }, "abstract": "<p>The methylguanadine derivative [<sup>11</sup>C]GMOM has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the [<sup>11</sup>C]GMOM radiation dose in healthy humans.</p>\n\n<p><strong>Methods:</strong> Following [<sup>11</sup>C]GMOM injection, three female and two male subjects underwent 10 consecutive whole body PET scans in approximately 77 minutes. 7 source organs were defined manually, scaled to a gender specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue weighting factors (ICRP103) were used to calculate the effective dose.</p>\n\n<p><strong>Results:</strong> Absorbed radiation doses in source organs ranged from 7.7 µGy·MBq<sup>-1</sup> in the brain to 12.7 µGy·MBq<sup>-1</sup> in the spleen. The effective dose (±SD) was 4.5 ± 0.5 µSv·MBq<sup>-1</sup></p>\n\n<p><strong>Conclusion:</strong> The effective dose of [<sup>11</sup>C]GMOM is at the lower end of the range seen for other C-11 labelled ligands, allowing for serial PET scanning in a single subject.</p>", "author": [ { "family": "van der Aart, Jasper" }, { "family": "van der Doef, Thalia F" }, { "family": "Horstman, Paul" }, { "family": "Huisman, Marc C" }, { "family": "Schuit, Robert C" }, { "family": "van Lingen, Arthur" }, { "family": "Windhorst, Albert D" }, { "family": "van Berckel, Bart,NM" }, { "family": "Lammerstma, Adriaan A" } ], "page": "1330-1333", "volume": "58", "type": "article-journal", "issue": "8", "id": "400829" }
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