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Human Dosimetry of the NMDA Receptor Ligand [11C]GMOM.

van der Aart, Jasper; van der Doef, Thalia F; Horstman, Paul; Huisman, Marc C; Schuit, Robert C; van Lingen, Arthur; Windhorst, Albert D; van Berckel, Bart,NM; Lammerstma, Adriaan A

The methylguanadine derivative [11C]GMOM has been used successfully to quantify N-methyl-D-aspartate (NMDA) receptor binding in humans. The purpose of the present study was to estimate the [11C]GMOM radiation dose in healthy humans.

Methods: Following [11C]GMOM injection, three female and two male subjects underwent 10 consecutive whole body PET scans in approximately 77 minutes. 7 source organs were defined manually, scaled to a gender specific reference, and residence times were calculated for input into OLINDA/EXM software. Accepted tissue weighting factors (ICRP103) were used to calculate the effective dose.

Results: Absorbed radiation doses in source organs ranged from 7.7 µGy·MBq-1 in the brain to 12.7 µGy·MBq-1 in the spleen. The effective dose (±SD) was 4.5 ± 0.5 µSv·MBq-1

Conclusion: The effective dose of [11C]GMOM is at the lower end of the range seen for other C-11 labelled ligands, allowing for serial PET scanning in a single subject.

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