4001718
doi
10.5281/zenodo.4001718
oai:zenodo.org:4001718
Boutros, Michael
Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg University, Heidelberg, Germany
Camp, J. Gray
Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland
Clarke, Laura
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
Clevers, Hans
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Oncode Institute and University Medical Center Utrecht, Utrecht, The Netherlands
Knoblich, Juergen A.
Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC), Vienna, Austria
Liberali, Prisca
Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland
Regev, Aviv
Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge
Rios, Anne C.
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands; Department of Cancer Research, Oncode Institute, Hubrecht Institute, KNAW Utrecht, Utrecht, The Netherlands; Cancer Genomics Center, Utrecht, The Netherlands
Stegle, Oliver
Divison of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany
Stunnenberg, Hendrik G.
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Teichmann, Sarah A.
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge UK; Cavendish Laboratory, University of Cambridge, Cambridge, UK
Treutlein, Barbara
Eidgenössische Technische Hochschule (ETH) Zurich, Department of Biosystems Science and Engineering, Basel, Switzerland
Vries, Robert G.J.
Foundation Hubrecht Organoid Technology, Utrecht, The Netherlands
The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy
Bock, Christoph
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Organoids
Single-cell profiling
High-throughput imaging
Multi-omics technology
Data resources
Bioinformatic tools
Integrative analysis
Biomedical applications
<p>Human organoids – three-dimensional structures of cells that recapitulate important aspects of organ development in vitro – hold tremendous potential for biomedical applications. To help deliver on the promises of combining human organoids with single-cell technology, we have launched an Organoid Cell Atlas pilot project, as a ‘Biological Network’ within the Human Cell Atlas (HCA), focusing on single-cell profiling of organoids and in vitro cell models (<a href="https://www.humancellatlas.org/coordinators/">https://www.humancellatlas.org/coordinators/</a>). The Organoid Cell Atlas will foster the production, quality control, dissemination, and utilization of single-cell and spatial genomics data for human organoids, and it will connect such datasets with the comprehensive profiles of primary tissue that are being generated within the HCA. A first step toward establishing the Organoid Cell Atlas has recently been funded by the European Union Horizon 2020 call for “Pilot actions to build the foundations of a human cell atlas” through the “HCA|Organoid” project (<a href="http://hca-organoid.eu/">http://hca-organoid.eu/</a>). This preprint outlines the rationale for combining human organoids with single-cell technology and the concrete plans for established the Organoid Cell Atlas as a Rosetta Stone for biomedical discovery and regenerative therapy.</p>
Zenodo
2020-08-30
info:eu-repo/semantics/article
4001717
1598749164.480133
1489206
md5:2b07ef2ef5ea7c5ff7b7416306d93c31
https://zenodo.org/records/4001718/files/The Organoid Cell Atlas - A Rosetta Stone for Biomedical Discovery and Regenerative Therapy (preprint).pdf
public
10.5281/zenodo.4001717
isVersionOf
doi