Journal article Open Access

The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy

Bock, Christoph; Boutros, Michael; Camp, J. Gray; Clarke, Laura; Clevers, Hans; Knoblich, Juergen A.; Liberali, Prisca; Regev, Aviv; Rios, Anne C.; Stegle, Oliver; Stunnenberg, Hendrik G.; Teichmann, Sarah A.; Treutlein, Barbara; Vries, Robert G.J.


MARC21 XML Export

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="942" ind1=" " ind2=" ">
    <subfield code="a">2020-08-30</subfield>
  </datafield>
  <datafield tag="041" ind1=" " ind2=" ">
    <subfield code="a">eng</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">Organoids</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">Single-cell profiling</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">High-throughput imaging</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">Multi-omics technology</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">Data resources</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">Bioinformatic tools</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">Integrative analysis</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">Biomedical applications</subfield>
  </datafield>
  <controlfield tag="005">20200830005924.0</controlfield>
  <controlfield tag="001">4001718</controlfield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg University, Heidelberg, Germany</subfield>
    <subfield code="a">Boutros, Michael</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland</subfield>
    <subfield code="a">Camp, J. Gray</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK</subfield>
    <subfield code="a">Clarke, Laura</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Oncode Institute and University Medical Center Utrecht, Utrecht, The Netherlands</subfield>
    <subfield code="a">Clevers, Hans</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC), Vienna, Austria</subfield>
    <subfield code="a">Knoblich, Juergen A.</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland</subfield>
    <subfield code="a">Liberali, Prisca</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge</subfield>
    <subfield code="a">Regev, Aviv</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands; Department of Cancer Research, Oncode Institute, Hubrecht Institute, KNAW Utrecht, Utrecht, The Netherlands; Cancer Genomics Center, Utrecht, The Netherlands</subfield>
    <subfield code="a">Rios, Anne C.</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Divison of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany</subfield>
    <subfield code="a">Stegle, Oliver</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands</subfield>
    <subfield code="a">Stunnenberg, Hendrik G.</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge UK; Cavendish Laboratory, University of Cambridge, Cambridge, UK</subfield>
    <subfield code="a">Teichmann, Sarah A.</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Eidgenössische Technische Hochschule (ETH) Zurich, Department of Biosystems Science and Engineering, Basel, Switzerland</subfield>
    <subfield code="a">Treutlein, Barbara</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Foundation Hubrecht Organoid Technology, Utrecht, The Netherlands</subfield>
    <subfield code="a">Vries, Robert G.J.</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">1489206</subfield>
    <subfield code="z">md5:2b07ef2ef5ea7c5ff7b7416306d93c31</subfield>
    <subfield code="u">https://zenodo.org/record/4001718/files/The Organoid Cell Atlas - A Rosetta Stone for Biomedical Discovery and Regenerative Therapy (preprint).pdf</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2020-08-30</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">openaire</subfield>
    <subfield code="o">oai:zenodo.org:4001718</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="u">CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria</subfield>
    <subfield code="0">(orcid)0000-0001-6091-3088</subfield>
    <subfield code="a">Bock, Christoph</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">https://creativecommons.org/licenses/by/4.0/legalcode</subfield>
    <subfield code="a">Creative Commons Attribution 4.0 International</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;Human organoids &amp;ndash; three-dimensional structures of cells that recapitulate important aspects of organ development in vitro &amp;ndash; hold tremendous potential for biomedical applications. To help deliver on the promises of combining human organoids with single-cell technology, we have launched an Organoid Cell Atlas pilot project, as a &amp;lsquo;Biological Network&amp;rsquo; within the Human Cell Atlas (HCA), focusing on single-cell profiling of organoids and in vitro cell models (&lt;a href="https://www.humancellatlas.org/coordinators/"&gt;https://www.humancellatlas.org/coordinators/&lt;/a&gt;). The Organoid Cell Atlas will foster the production, quality control, dissemination, and utilization of single-cell and spatial genomics data for human organoids, and it will connect such datasets with the comprehensive profiles of primary tissue that are being generated within the HCA. A first step toward establishing the Organoid Cell Atlas has recently been funded by the European Union Horizon 2020 call for &amp;ldquo;Pilot actions to build the foundations of a human cell atlas&amp;rdquo; through the &amp;ldquo;HCA|Organoid&amp;rdquo; project (&lt;a href="http://hca-organoid.eu/"&gt;http://hca-organoid.eu/&lt;/a&gt;). This preprint outlines the rationale for combining human organoids with single-cell technology and the concrete plans for established the Organoid Cell Atlas as a Rosetta Stone for biomedical discovery and regenerative therapy.&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="773" ind1=" " ind2=" ">
    <subfield code="n">doi</subfield>
    <subfield code="i">isVersionOf</subfield>
    <subfield code="a">10.5281/zenodo.4001717</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.5281/zenodo.4001718</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
</record>
1,446
1,042
views
downloads
All versions This version
Views 1,4461,446
Downloads 1,0421,042
Data volume 1.6 GB1.6 GB
Unique views 1,2541,254
Unique downloads 952952

Share

Cite as