Journal article Open Access

The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy

Bock, Christoph; Boutros, Michael; Camp, J. Gray; Clarke, Laura; Clevers, Hans; Knoblich, Juergen A.; Liberali, Prisca; Regev, Aviv; Rios, Anne C.; Stegle, Oliver; Stunnenberg, Hendrik G.; Teichmann, Sarah A.; Treutlein, Barbara; Vries, Robert G.J.


DCAT Export

<?xml version='1.0' encoding='utf-8'?>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:adms="http://www.w3.org/ns/adms#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dct="http://purl.org/dc/terms/" xmlns:dctype="http://purl.org/dc/dcmitype/" xmlns:dcat="http://www.w3.org/ns/dcat#" xmlns:duv="http://www.w3.org/ns/duv#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:frapo="http://purl.org/cerif/frapo/" xmlns:geo="http://www.w3.org/2003/01/geo/wgs84_pos#" xmlns:gsp="http://www.opengis.net/ont/geosparql#" xmlns:locn="http://www.w3.org/ns/locn#" xmlns:org="http://www.w3.org/ns/org#" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:prov="http://www.w3.org/ns/prov#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:schema="http://schema.org/" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:vcard="http://www.w3.org/2006/vcard/ns#" xmlns:wdrs="http://www.w3.org/2007/05/powder-s#">
  <rdf:Description rdf:about="https://doi.org/10.5281/zenodo.4001718">
    <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://doi.org/10.5281/zenodo.4001718</dct:identifier>
    <foaf:page rdf:resource="https://doi.org/10.5281/zenodo.4001718"/>
    <dct:creator>
      <rdf:Description rdf:about="http://orcid.org/0000-0001-6091-3088">
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">0000-0001-6091-3088</dct:identifier>
        <foaf:name>Bock, Christoph</foaf:name>
        <foaf:givenName>Christoph</foaf:givenName>
        <foaf:familyName>Bock</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Boutros, Michael</foaf:name>
        <foaf:givenName>Michael</foaf:givenName>
        <foaf:familyName>Boutros</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Division Signaling and Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg University, Heidelberg, Germany</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Camp, J. Gray</foaf:name>
        <foaf:givenName>J. Gray</foaf:givenName>
        <foaf:familyName>Camp</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Clarke, Laura</foaf:name>
        <foaf:givenName>Laura</foaf:givenName>
        <foaf:familyName>Clarke</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Clevers, Hans</foaf:name>
        <foaf:givenName>Hans</foaf:givenName>
        <foaf:familyName>Clevers</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Oncode Institute and University Medical Center Utrecht, Utrecht, The Netherlands</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Knoblich, Juergen A.</foaf:name>
        <foaf:givenName>Juergen A.</foaf:givenName>
        <foaf:familyName>Knoblich</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC), Vienna, Austria</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Liberali, Prisca</foaf:name>
        <foaf:givenName>Prisca</foaf:givenName>
        <foaf:familyName>Liberali</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Regev, Aviv</foaf:name>
        <foaf:givenName>Aviv</foaf:givenName>
        <foaf:familyName>Regev</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Rios, Anne C.</foaf:name>
        <foaf:givenName>Anne C.</foaf:givenName>
        <foaf:familyName>Rios</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands; Department of Cancer Research, Oncode Institute, Hubrecht Institute, KNAW Utrecht, Utrecht, The Netherlands; Cancer Genomics Center, Utrecht, The Netherlands</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Stegle, Oliver</foaf:name>
        <foaf:givenName>Oliver</foaf:givenName>
        <foaf:familyName>Stegle</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Divison of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Stunnenberg, Hendrik G.</foaf:name>
        <foaf:givenName>Hendrik G.</foaf:givenName>
        <foaf:familyName>Stunnenberg</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Teichmann, Sarah A.</foaf:name>
        <foaf:givenName>Sarah A.</foaf:givenName>
        <foaf:familyName>Teichmann</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge UK; Cavendish Laboratory, University of Cambridge, Cambridge, UK</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Treutlein, Barbara</foaf:name>
        <foaf:givenName>Barbara</foaf:givenName>
        <foaf:familyName>Treutlein</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Eidgenössische Technische Hochschule (ETH) Zurich, Department of Biosystems Science and Engineering, Basel, Switzerland</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Vries, Robert G.J.</foaf:name>
        <foaf:givenName>Robert G.J.</foaf:givenName>
        <foaf:familyName>Vries</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Foundation Hubrecht Organoid Technology, Utrecht, The Netherlands</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:title>The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy</dct:title>
    <dct:publisher>
      <foaf:Agent>
        <foaf:name>Zenodo</foaf:name>
      </foaf:Agent>
    </dct:publisher>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2020</dct:issued>
    <dcat:keyword>Organoids</dcat:keyword>
    <dcat:keyword>Single-cell profiling</dcat:keyword>
    <dcat:keyword>High-throughput imaging</dcat:keyword>
    <dcat:keyword>Multi-omics technology</dcat:keyword>
    <dcat:keyword>Data resources</dcat:keyword>
    <dcat:keyword>Bioinformatic tools</dcat:keyword>
    <dcat:keyword>Integrative analysis</dcat:keyword>
    <dcat:keyword>Biomedical applications</dcat:keyword>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2020-08-30</dct:issued>
    <dct:language rdf:resource="http://publications.europa.eu/resource/authority/language/ENG"/>
    <owl:sameAs rdf:resource="https://zenodo.org/record/4001718"/>
    <adms:identifier>
      <adms:Identifier>
        <skos:notation rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/4001718</skos:notation>
        <adms:schemeAgency>url</adms:schemeAgency>
      </adms:Identifier>
    </adms:identifier>
    <dct:isVersionOf rdf:resource="https://doi.org/10.5281/zenodo.4001717"/>
    <dct:description>&lt;p&gt;Human organoids &amp;ndash; three-dimensional structures of cells that recapitulate important aspects of organ development in vitro &amp;ndash; hold tremendous potential for biomedical applications. To help deliver on the promises of combining human organoids with single-cell technology, we have launched an Organoid Cell Atlas pilot project, as a &amp;lsquo;Biological Network&amp;rsquo; within the Human Cell Atlas (HCA), focusing on single-cell profiling of organoids and in vitro cell models (&lt;a href="https://www.humancellatlas.org/coordinators/"&gt;https://www.humancellatlas.org/coordinators/&lt;/a&gt;). The Organoid Cell Atlas will foster the production, quality control, dissemination, and utilization of single-cell and spatial genomics data for human organoids, and it will connect such datasets with the comprehensive profiles of primary tissue that are being generated within the HCA. A first step toward establishing the Organoid Cell Atlas has recently been funded by the European Union Horizon 2020 call for &amp;ldquo;Pilot actions to build the foundations of a human cell atlas&amp;rdquo; through the &amp;ldquo;HCA|Organoid&amp;rdquo; project (&lt;a href="http://hca-organoid.eu/"&gt;http://hca-organoid.eu/&lt;/a&gt;). This preprint outlines the rationale for combining human organoids with single-cell technology and the concrete plans for established the Organoid Cell Atlas as a Rosetta Stone for biomedical discovery and regenerative therapy.&lt;/p&gt;</dct:description>
    <dct:accessRights rdf:resource="http://publications.europa.eu/resource/authority/access-right/PUBLIC"/>
    <dct:accessRights>
      <dct:RightsStatement rdf:about="info:eu-repo/semantics/openAccess">
        <rdfs:label>Open Access</rdfs:label>
      </dct:RightsStatement>
    </dct:accessRights>
    <dct:license rdf:resource="https://creativecommons.org/licenses/by/4.0/legalcode"/>
    <dcat:distribution>
      <dcat:Distribution>
        <dcat:accessURL rdf:resource="https://doi.org/10.5281/zenodo.4001718"/>
        <dcat:byteSize>1489206</dcat:byteSize>
        <dcat:downloadURL rdf:resource="https://zenodo.org/record/4001718/files/The Organoid Cell Atlas - A Rosetta Stone for Biomedical Discovery and Regenerative Therapy (preprint).pdf"/>
        <dcat:mediaType>application/pdf</dcat:mediaType>
      </dcat:Distribution>
    </dcat:distribution>
  </rdf:Description>
</rdf:RDF>
1,450
1,046
views
downloads
All versions This version
Views 1,4501,450
Downloads 1,0461,046
Data volume 1.6 GB1.6 GB
Unique views 1,2581,258
Unique downloads 955955

Share

Cite as