Journal article Open Access

The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy

Bock, Christoph; Boutros, Michael; Camp, J. Gray; Clarke, Laura; Clevers, Hans; Knoblich, Juergen A.; Liberali, Prisca; Regev, Aviv; Rios, Anne C.; Stegle, Oliver; Stunnenberg, Hendrik G.; Teichmann, Sarah A.; Treutlein, Barbara; Vries, Robert G.J.


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{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.4001718", 
  "language": "eng", 
  "title": "The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy", 
  "issued": {
    "date-parts": [
      [
        2020, 
        8, 
        30
      ]
    ]
  }, 
  "abstract": "<p>Human organoids &ndash; three-dimensional structures of cells that recapitulate important aspects of organ development in vitro &ndash; hold tremendous potential for biomedical applications. To help deliver on the promises of combining human organoids with single-cell technology, we have launched an Organoid Cell Atlas pilot project, as a &lsquo;Biological Network&rsquo; within the Human Cell Atlas (HCA), focusing on single-cell profiling of organoids and in vitro cell models (<a href=\"https://www.humancellatlas.org/coordinators/\">https://www.humancellatlas.org/coordinators/</a>). The Organoid Cell Atlas will foster the production, quality control, dissemination, and utilization of single-cell and spatial genomics data for human organoids, and it will connect such datasets with the comprehensive profiles of primary tissue that are being generated within the HCA. A first step toward establishing the Organoid Cell Atlas has recently been funded by the European Union Horizon 2020 call for &ldquo;Pilot actions to build the foundations of a human cell atlas&rdquo; through the &ldquo;HCA|Organoid&rdquo; project (<a href=\"http://hca-organoid.eu/\">http://hca-organoid.eu/</a>). This preprint outlines the rationale for combining human organoids with single-cell technology and the concrete plans for established the Organoid Cell Atlas as a Rosetta Stone for biomedical discovery and regenerative therapy.</p>", 
  "author": [
    {
      "family": "Bock, Christoph"
    }, 
    {
      "family": "Boutros, Michael"
    }, 
    {
      "family": "Camp, J. Gray"
    }, 
    {
      "family": "Clarke, Laura"
    }, 
    {
      "family": "Clevers, Hans"
    }, 
    {
      "family": "Knoblich, Juergen A."
    }, 
    {
      "family": "Liberali, Prisca"
    }, 
    {
      "family": "Regev, Aviv"
    }, 
    {
      "family": "Rios, Anne C."
    }, 
    {
      "family": "Stegle, Oliver"
    }, 
    {
      "family": "Stunnenberg, Hendrik G."
    }, 
    {
      "family": "Teichmann, Sarah A."
    }, 
    {
      "family": "Treutlein, Barbara"
    }, 
    {
      "family": "Vries, Robert G.J."
    }
  ], 
  "type": "article-journal", 
  "id": "4001718"
}
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