Preprint Open Access
Eradicate Coronavirus by blocking replication, counteracting its defense system
Kira Smith
SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as HIF-1α with the target genes and cytokines. Autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.
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- Publication date:
- March 18, 2020
- DOI:
-
- Keyword(s):
- Coronavirus Covid-19 Covid Sars-Cov-2 Coronavirus replication SIRT1 inhibitors SIRT1 p53 mTOR Autophagy Lysosomotropic HIF-1α HIF Cytokines Cytokines Storm
- Communities:
- License (for files):
- Creative Commons Attribution 4.0 International