Journal article Open Access

First in vivo MRI study on theranostic dendrimersomes.

Filippi, Miriam; Catanzaro, Valeria; Patrucco, Deyssy; Botta, Mauro; Tei, Lorenzo; Terreno, Enzo


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  <identifier identifierType="URL">https://zenodo.org/record/398791</identifier>
  <creators>
    <creator>
      <creatorName>Filippi, Miriam</creatorName>
      <givenName>Miriam</givenName>
      <familyName>Filippi</familyName>
      <affiliation>Centro di Imaging Molecolare e Preclinico, Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Università di Torino, Via Nizza 52, 10126 Torino, Italia.</affiliation>
    </creator>
    <creator>
      <creatorName>Catanzaro, Valeria</creatorName>
      <givenName>Valeria</givenName>
      <familyName>Catanzaro</familyName>
      <affiliation>Centro di Imaging Molecolare e Preclinico, Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Università di Torino, Via Nizza 52, 10126 Torino, Italia.</affiliation>
    </creator>
    <creator>
      <creatorName>Patrucco, Deyssy</creatorName>
      <givenName>Deyssy</givenName>
      <familyName>Patrucco</familyName>
      <affiliation>Centro di Imaging Molecolare e Preclinico, Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Università di Torino, Via Nizza 52, 10126 Torino, Italia.</affiliation>
    </creator>
    <creator>
      <creatorName>Botta, Mauro</creatorName>
      <givenName>Mauro</givenName>
      <familyName>Botta</familyName>
      <affiliation>Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, 15121 Alessandria, Italia.</affiliation>
    </creator>
    <creator>
      <creatorName>Tei, Lorenzo</creatorName>
      <givenName>Lorenzo</givenName>
      <familyName>Tei</familyName>
      <affiliation>Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, 15121 Alessandria, Italia.</affiliation>
    </creator>
    <creator>
      <creatorName>Terreno, Enzo</creatorName>
      <givenName>Enzo</givenName>
      <familyName>Terreno</familyName>
      <affiliation>Centro di Imaging Molecolare e Preclinico, Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Università di Torino, Via Nizza 52, 10126 Torino, Italia.</affiliation>
    </creator>
  </creators>
  <titles>
    <title>First in vivo MRI study on theranostic dendrimersomes.</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2017</publicationYear>
  <subjects>
    <subject>Dendrimersomes</subject>
    <subject>prednisolone phosphate</subject>
    <subject>melanoma</subject>
    <subject>theranostic,</subject>
    <subject>magnetic resonance imaging</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2017-02-28</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/398791</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.jconrel.2017.01.010</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/ecfunded</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/inmind</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Amphiphilic Janus-dendrimers are able to self-assemble into nanosized vesicles named dendrimersomes. We recently synthesized the 3,5-C&lt;sub&gt;12&lt;/sub&gt;-EG-(OH)&lt;sub&gt;4&lt;/sub&gt; dendrimer that generates dendrimersomes with very promising safety and stability profiles, that can be loaded with different contrast agents for in vivo imaging. In this contribution, nanovesicles were loaded with both the Magnetic Resonance Imaging (MRI) reporter GdDOTAGA(C&lt;sub&gt;18&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt; and the glucocorticoid drug Prednisolone Phosphate (PLP), in order to test their effective potential as theranostic nanocarriers on murine melanoma tumour models. The incorporation of GdDOTAGA(C&lt;sub&gt;18&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt; into the membrane resulted in dendrimersomes with a high longitudinal relaxivity (r&lt;sub&gt;1&lt;/sub&gt;=39.1mM&lt;sup&gt;-1&lt;/sup&gt;s&lt;sup&gt;-1&lt;/sup&gt;, at 310K and 40MHz) so that, after intravenous administration, T&lt;sub&gt;1&lt;/sub&gt;-weighted MRI showed a consistent contrast enhancement in the tumour area. Furthermore, the nanovesicles encapsulated PLP with good efficiency and displayed anti-tumour activity both in vitro and in vivo, thus enabling their practical use for biomedical theranostic applications.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/FP7/278850/">278850</awardNumber>
      <awardTitle>Imaging of Neuroinflammation in Neurodegenerative Diseases</awardTitle>
    </fundingReference>
  </fundingReferences>
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