Journal article Open Access

First in vivo MRI study on theranostic dendrimersomes.

Filippi, Miriam; Catanzaro, Valeria; Patrucco, Deyssy; Botta, Mauro; Tei, Lorenzo; Terreno, Enzo


DCAT Export

<?xml version='1.0' encoding='utf-8'?>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:adms="http://www.w3.org/ns/adms#" xmlns:cnt="http://www.w3.org/2011/content#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dct="http://purl.org/dc/terms/" xmlns:dctype="http://purl.org/dc/dcmitype/" xmlns:dcat="http://www.w3.org/ns/dcat#" xmlns:duv="http://www.w3.org/ns/duv#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:frapo="http://purl.org/cerif/frapo/" xmlns:geo="http://www.w3.org/2003/01/geo/wgs84_pos#" xmlns:gsp="http://www.opengis.net/ont/geosparql#" xmlns:locn="http://www.w3.org/ns/locn#" xmlns:org="http://www.w3.org/ns/org#" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:prov="http://www.w3.org/ns/prov#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:schema="http://schema.org/" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:vcard="http://www.w3.org/2006/vcard/ns#" xmlns:wdrs="http://www.w3.org/2007/05/powder-s#">
  <rdf:Description rdf:about="https://zenodo.org/record/398791">
    <rdf:type rdf:resource="http://www.w3.org/ns/dcat#Dataset"/>
    <dct:type rdf:resource="http://purl.org/dc/dcmitype/Text"/>
    <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/398791</dct:identifier>
    <foaf:page rdf:resource="https://zenodo.org/record/398791"/>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Filippi, Miriam</foaf:name>
        <foaf:givenName>Miriam</foaf:givenName>
        <foaf:familyName>Filippi</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Centro di Imaging Molecolare e Preclinico, Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Università di Torino, Via Nizza 52, 10126 Torino, Italia.</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Catanzaro, Valeria</foaf:name>
        <foaf:givenName>Valeria</foaf:givenName>
        <foaf:familyName>Catanzaro</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Centro di Imaging Molecolare e Preclinico, Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Università di Torino, Via Nizza 52, 10126 Torino, Italia.</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Patrucco, Deyssy</foaf:name>
        <foaf:givenName>Deyssy</foaf:givenName>
        <foaf:familyName>Patrucco</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Centro di Imaging Molecolare e Preclinico, Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Università di Torino, Via Nizza 52, 10126 Torino, Italia.</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Botta, Mauro</foaf:name>
        <foaf:givenName>Mauro</foaf:givenName>
        <foaf:familyName>Botta</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, 15121 Alessandria, Italia.</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Tei, Lorenzo</foaf:name>
        <foaf:givenName>Lorenzo</foaf:givenName>
        <foaf:familyName>Tei</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale "Amedeo Avogadro", Viale T. Michel 11, 15121 Alessandria, Italia.</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:creator>
      <rdf:Description>
        <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/>
        <foaf:name>Terreno, Enzo</foaf:name>
        <foaf:givenName>Enzo</foaf:givenName>
        <foaf:familyName>Terreno</foaf:familyName>
        <org:memberOf>
          <foaf:Organization>
            <foaf:name>Centro di Imaging Molecolare e Preclinico, Dipartimento di Biotecnologie Molecolari e Scienze della Salute, Università di Torino, Via Nizza 52, 10126 Torino, Italia.</foaf:name>
          </foaf:Organization>
        </org:memberOf>
      </rdf:Description>
    </dct:creator>
    <dct:title>First in vivo MRI study on theranostic dendrimersomes.</dct:title>
    <dct:publisher>
      <foaf:Agent>
        <foaf:name>Zenodo</foaf:name>
      </foaf:Agent>
    </dct:publisher>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2017</dct:issued>
    <dcat:keyword>Dendrimersomes</dcat:keyword>
    <dcat:keyword>prednisolone phosphate</dcat:keyword>
    <dcat:keyword>melanoma</dcat:keyword>
    <dcat:keyword>theranostic,</dcat:keyword>
    <dcat:keyword>magnetic resonance imaging</dcat:keyword>
    <frapo:isFundedBy rdf:resource="info:eu-repo/grantAgreement/EC/FP7/278850/"/>
    <schema:funder>
      <foaf:Organization>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.13039/501100000780</dct:identifier>
        <foaf:name>European Commission</foaf:name>
      </foaf:Organization>
    </schema:funder>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2017-02-28</dct:issued>
    <owl:sameAs rdf:resource="https://zenodo.org/record/398791"/>
    <adms:identifier>
      <adms:Identifier>
        <skos:notation rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/398791</skos:notation>
      </adms:Identifier>
    </adms:identifier>
    <owl:sameAs rdf:resource="https://doi.org/10.1016/j.jconrel.2017.01.010"/>
    <dct:isPartOf rdf:resource="https://zenodo.org/communities/ecfunded"/>
    <dct:isPartOf rdf:resource="https://zenodo.org/communities/inmind"/>
    <dct:description>&lt;p&gt;Amphiphilic Janus-dendrimers are able to self-assemble into nanosized vesicles named dendrimersomes. We recently synthesized the 3,5-C&lt;sub&gt;12&lt;/sub&gt;-EG-(OH)&lt;sub&gt;4&lt;/sub&gt; dendrimer that generates dendrimersomes with very promising safety and stability profiles, that can be loaded with different contrast agents for in vivo imaging. In this contribution, nanovesicles were loaded with both the Magnetic Resonance Imaging (MRI) reporter GdDOTAGA(C&lt;sub&gt;18&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt; and the glucocorticoid drug Prednisolone Phosphate (PLP), in order to test their effective potential as theranostic nanocarriers on murine melanoma tumour models. The incorporation of GdDOTAGA(C&lt;sub&gt;18&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt; into the membrane resulted in dendrimersomes with a high longitudinal relaxivity (r&lt;sub&gt;1&lt;/sub&gt;=39.1mM&lt;sup&gt;-1&lt;/sup&gt;s&lt;sup&gt;-1&lt;/sup&gt;, at 310K and 40MHz) so that, after intravenous administration, T&lt;sub&gt;1&lt;/sub&gt;-weighted MRI showed a consistent contrast enhancement in the tumour area. Furthermore, the nanovesicles encapsulated PLP with good efficiency and displayed anti-tumour activity both in vitro and in vivo, thus enabling their practical use for biomedical theranostic applications.&lt;/p&gt;</dct:description>
    <dct:accessRights rdf:resource="http://publications.europa.eu/resource/authority/access-right/PUBLIC"/>
    <dct:accessRights>
      <dct:RightsStatement rdf:about="info:eu-repo/semantics/openAccess">
        <rdfs:label>Open Access</rdfs:label>
      </dct:RightsStatement>
    </dct:accessRights>
    <dcat:distribution>
      <dcat:Distribution>
        <dct:license rdf:resource="http://creativecommons.org/licenses/by/4.0/legalcode"/>
        <dcat:accessURL rdf:resource="https://zenodo.org/record/398791"/>
      </dcat:Distribution>
    </dcat:distribution>
  </rdf:Description>
  <foaf:Project rdf:about="info:eu-repo/grantAgreement/EC/FP7/278850/">
    <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">278850</dct:identifier>
    <dct:title>Imaging of Neuroinflammation in Neurodegenerative Diseases</dct:title>
    <frapo:isAwardedBy>
      <foaf:Organization>
        <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.13039/501100000780</dct:identifier>
        <foaf:name>European Commission</foaf:name>
      </foaf:Organization>
    </frapo:isAwardedBy>
  </foaf:Project>
</rdf:RDF>
16
25
views
downloads
Views 16
Downloads 25
Data volume 19.3 MB
Unique views 15
Unique downloads 25

Share

Cite as