Preprint Open Access
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="041" ind1=" " ind2=" "> <subfield code="a">eng</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Coronavirus</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Covid-19</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Covid</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Sars-Cov-2</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Coronavirus replication</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">SIRT1 inhibitors</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">SIRT1</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">p53</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">mTOR</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Autophagy</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Lysosomotropic</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Tenovin</subfield> </datafield> <controlfield tag="005">20210322085949.0</controlfield> <datafield tag="500" ind1=" " ind2=" "> <subfield code="a">Created and uploaded on Academia.edu on March 2020.</subfield> </datafield> <controlfield tag="001">3976104</controlfield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="s">232391</subfield> <subfield code="z">md5:5756da5d34b1b32981a122cedfb4ee7b</subfield> <subfield code="u">https://zenodo.org/record/3976104/files/Covid19Eradicate.pdf</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2020-08-03</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="p">openaire</subfield> <subfield code="p">user-covid-19</subfield> <subfield code="p">user-covid19-structure-hub</subfield> <subfield code="p">user-eradicatecovid19</subfield> <subfield code="o">oai:zenodo.org:3976104</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="0">(orcid)0000-0003-4306-4365</subfield> <subfield code="a">Kira Smith</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Eradicate Coronavirus by blocking replication, counteracting its defense system</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-covid-19</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-covid19-structure-hub</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-eradicatecovid19</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">https://creativecommons.org/licenses/by/4.0/legalcode</subfield> <subfield code="a">Creative Commons Attribution 4.0 International</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="a">cc-by</subfield> <subfield code="2">opendefinition.org</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a"><p>SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.</p></subfield> </datafield> <datafield tag="773" ind1=" " ind2=" "> <subfield code="n">doi</subfield> <subfield code="i">isVersionOf</subfield> <subfield code="a">10.5281/zenodo.3971127</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.5281/zenodo.3976104</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">preprint</subfield> </datafield> </record>
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