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Eradicate Coronavirus by blocking replication, counteracting its defense system

Kira Smith


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{
  "inLanguage": {
    "alternateName": "eng", 
    "@type": "Language", 
    "name": "English"
  }, 
  "description": "<p>SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "@id": "https://orcid.org/0000-0003-4306-4365", 
      "@type": "Person", 
      "name": "Kira Smith"
    }
  ], 
  "headline": "Eradicate Coronavirus by blocking replication, counteracting its defense system", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2020-08-03", 
  "url": "https://zenodo.org/record/3976104", 
  "version": "3.0", 
  "keywords": [
    "Coronavirus", 
    "Covid-19", 
    "Covid", 
    "Sars-Cov-2", 
    "Coronavirus replication", 
    "SIRT1 inhibitors", 
    "SIRT1", 
    "p53", 
    "mTOR", 
    "Autophagy", 
    "Lysosomotropic", 
    "Tenovin"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.3976104", 
  "@id": "https://doi.org/10.5281/zenodo.3976104", 
  "@type": "ScholarlyArticle", 
  "name": "Eradicate Coronavirus by blocking replication, counteracting its defense system"
}
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