{ "access": { "embargo": { "active": false, "reason": null }, "files": "public", "record": "public", "status": "open" }, "created": "2020-08-07T21:02:27.580371+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "files": { "count": 1, "enabled": true, "entries": { "Covid19Eradicate.pdf": { "checksum": "md5:5756da5d34b1b32981a122cedfb4ee7b", "ext": "pdf", "id": "7c0c9584-4cbb-4d0e-bf3b-5d80cb283303", "key": "Covid19Eradicate.pdf", "metadata": null, "mimetype": "application/pdf", "size": 232391 } }, "order": [], "total_bytes": 232391 }, "id": "3976104", "is_draft": false, "is_published": true, "links": { "access": "https://zenodo.org/api/records/3976104/access", "access_links": "https://zenodo.org/api/records/3976104/access/links", "access_request": "https://zenodo.org/api/records/3976104/access/request", "access_users": "https://zenodo.org/api/records/3976104/access/users", "archive": "https://zenodo.org/api/records/3976104/files-archive", "archive_media": "https://zenodo.org/api/records/3976104/media-files-archive", "communities": "https://zenodo.org/api/records/3976104/communities", "communities-suggestions": "https://zenodo.org/api/records/3976104/communities-suggestions", "doi": "https://doi.org/10.5281/zenodo.3976104", "draft": "https://zenodo.org/api/records/3976104/draft", "files": "https://zenodo.org/api/records/3976104/files", "latest": "https://zenodo.org/api/records/3976104/versions/latest", "latest_html": "https://zenodo.org/records/3976104/latest", "media_files": "https://zenodo.org/api/records/3976104/media-files", "parent": "https://zenodo.org/api/records/3971127", "parent_doi": "https://zenodo.org/doi/10.5281/zenodo.3971127", "parent_html": "https://zenodo.org/records/3971127", "requests": "https://zenodo.org/api/records/3976104/requests", "reserve_doi": "https://zenodo.org/api/records/3976104/draft/pids/doi", "self": "https://zenodo.org/api/records/3976104", "self_doi": "https://zenodo.org/doi/10.5281/zenodo.3976104", "self_html": "https://zenodo.org/records/3976104", "self_iiif_manifest": "https://zenodo.org/api/iiif/record:3976104/manifest", "self_iiif_sequence": "https://zenodo.org/api/iiif/record:3976104/sequence/default", "versions": "https://zenodo.org/api/records/3976104/versions" }, "media_files": { "count": 0, "enabled": false, "entries": {}, "order": [], "total_bytes": 0 }, "metadata": { "additional_descriptions": [ { "description": "Created and uploaded on Academia.edu on March 2020.", "type": { "id": "notes", "title": { "de": "Anmerkungen", "en": "Notes" } } } ], "creators": [ { "person_or_org": { "family_name": "Kira Smith", "identifiers": [ { "identifier": "0000-0003-4306-4365", "scheme": "orcid" } ], "name": "Kira Smith", "type": "personal" } } ], "description": "
SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.
", "languages": [ { "id": "eng", "title": { "en": "English" } } ], "publication_date": "2020-08-03", "publisher": "Zenodo", "resource_type": { "id": "publication-preprint", "title": { "de": "Preprint", "en": "Preprint" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "Coronavirus" }, { "subject": "Covid-19" }, { "subject": "Covid" }, { "subject": "Sars-Cov-2" }, { "subject": "Coronavirus replication" }, { "subject": "SIRT1 inhibitors" }, { "subject": "SIRT1" }, { "subject": "p53" }, { "subject": "mTOR" }, { "subject": "Autophagy" }, { "subject": "Lysosomotropic" }, { "subject": "Tenovin" } ], "title": "Eradicate Coronavirus by blocking replication, counteracting its defense system", "version": "3.0" }, "parent": { "access": { "owned_by": { "user": 118559 } }, "communities": { "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2020-03-16T11:40:44.487619+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "10f33f78-3f29-41b6-bb10-f757a8f03cb8", "links": {}, "metadata": { "curation_policy": "The Coronavirus Disease Research Community - COVID-19 is curated by a selected team of experts nominated by OpenAIRE* (see list below). Each time a Zenodo user wants to add a record into the community, an email is sent to the curators that will decide whether to include the record or not.
\r\n\r\nOnly records that may be relevant to the Corona Virus Disease (COVID-19) or the SARS-CoV-2 should be included in this community. The Community curators are not able to edit records, therefore they may ask the corresponding authors to modify the record metadata when necessary, to provide the readers/users with more detailed information according to the FAIR principle of Open Science.
\r\n\r\nIf after its acceptance, a record is subsequently found not to be compliant, we reserve the right to remove it from the community.
\r\n\r\nThe curation team is reachable through the following email address for further clarification or information: covid19@openaire.eu.
\r\n\r\nCurator List:
\r\n\r\n* OpenAIRE: open access and open science training and support since 2009. OpenAIRE is the largest aggregator of European Commission funded research outputs and beyond, also delivering on-demand services for research communities.
\r\n", "page": "This community collects research outputs that may be relevant to the Coronavirus Disease (COVID-19) or the SARS-CoV-2. Scientists are encouraged to upload their outcome in this collection to facilitate sharing and discovery of information. Although Open Access articles and datasets are recommended, also closed and restricted access material are accepted. All types of research outputs can be included in this Community (Publication, Poster, Presentation, Dataset, Image, Video/Audio, Software, Lesson, Other).
\r\n\r\nThe recent Corona Virus Disease (COVID-19) outbreak is requiring unseen efforts of collaboration of the scientific community that need to act fast and to share results in an unpredictable manner. In order to facilitate the Scientist efforts, this community was created to collect all research results that could be relevant for the scientific community working on the Corona Virus Disease (COVID-19) and SARS-CoV-2.
\r\n\r\nAlthough Open Access articles and datasets are recommended, also closed and restricted access material are accepted. All types of research outputs can be included in this Community (Publication, Poster, Presentation, Dataset, Image, Video/Audio, Software, Lesson, Other).
\r\n\r\nWhen depositing a resource that is linked to other resources (not limited to the records deposited in Zenodo but also in other repositories), please make sure that your record is linked to all the other related elements already available, in order to adhere to the FAIR principles of Open Science to maximise the reusability of research results.
\r\n\r\n", "title": "Coronavirus Disease Research Community - COVID-19" }, "revision_id": 0, "slug": "covid-19", "updated": "2021-02-23T14:39:53.029415+00:00" }, { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2020-06-23T17:45:07.984389+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "1bb60a30-a715-4f82-97c9-17bdf6cc940f", "links": {}, "metadata": { "curation_policy": "", "description": "A community-driven data repository and curation service for molecular structures, models, therapeutics, and simulations related to computational research related to therapeutic opportunities for COVID-19 (caused by the SARS-CoV-2 coronavirus).", "page": "
A community-driven data repository and curation service for molecular structures, models, therapeutics, and simulations related to computational research related to therapeutic opportunities for COVID-19 (caused by the SARS-CoV-2 coronavirus). For more info about the project, see the about page.
\r\n\r\nThe repository collects high-quality data related to:
\r\n\r\nWelcome to the new community against Coronavirus.
\r\n\r\nThe efforts of all researchers could permit to get the Key to fight Covid-19 and eradicate it.
\r\n\r\nAll researches concerning Covid and its biological action in the organism, mechanism of entry into the host, any potential treatments will be published here.
\r\n\r\nDiscussions, theses, hypotheses regarding vaccines are also being accepted.
\r\n\r\nClinical and Experimental Medicine, MD
\r\nSecurity Specialist for Special Operations in Unconventional Warfare UW