August 3, 2020 Preprint Open Access

Kira Smith

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  <identifier identifierType="DOI">10.5281/zenodo.3976104</identifier>
  <creators>
    <creator>
      <creatorName>Kira Smith</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-4306-4365</nameIdentifier>
    </creator>
  </creators>
  <titles>
    <title>Eradicate Coronavirus by blocking replication, counteracting its defense system</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2020</publicationYear>
  <subjects>
    <subject>Coronavirus</subject>
    <subject>Covid-19</subject>
    <subject>Covid</subject>
    <subject>Sars-Cov-2</subject>
    <subject>Coronavirus replication</subject>
    <subject>SIRT1 inhibitors</subject>
    <subject>SIRT1</subject>
    <subject>p53</subject>
    <subject>mTOR</subject>
    <subject>Autophagy</subject>
    <subject>Lysosomotropic</subject>
    <subject>Tenovin</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2020-08-03</date>
  </dates>
  <language>en</language>
  <resourceType resourceTypeGeneral="Preprint"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/3976104</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.3971127</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/covid-19</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/covid19-structure-hub</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/eradicatecovid19</relatedIdentifier>
  </relatedIdentifiers>
  <version>3.0</version>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.&lt;/p&gt;</description>
    <description descriptionType="Other">Created and uploaded on Academia.edu on March 2020.</description>
  </descriptions>
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