August 3, 2020 Preprint Open Access

Kira Smith

DCAT Export

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        <foaf:name>Kira Smith</foaf:name>
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    <dct:title>Eradicate Coronavirus by blocking replication, counteracting its defense system</dct:title>
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    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2020</dct:issued>
    <dcat:keyword>Coronavirus</dcat:keyword>
    <dcat:keyword>Covid-19</dcat:keyword>
    <dcat:keyword>Covid</dcat:keyword>
    <dcat:keyword>Sars-Cov-2</dcat:keyword>
    <dcat:keyword>Coronavirus replication</dcat:keyword>
    <dcat:keyword>SIRT1 inhibitors</dcat:keyword>
    <dcat:keyword>SIRT1</dcat:keyword>
    <dcat:keyword>p53</dcat:keyword>
    <dcat:keyword>mTOR</dcat:keyword>
    <dcat:keyword>Autophagy</dcat:keyword>
    <dcat:keyword>Lysosomotropic</dcat:keyword>
    <dcat:keyword>Tenovin</dcat:keyword>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2020-08-03</dct:issued>
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    <dct:description>&lt;p&gt;SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.&lt;/p&gt;</dct:description>
    <dct:description>Created and uploaded on Academia.edu on March 2020.</dct:description>
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