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Preprint Open Access

Eradicate Coronavirus by blocking replication, counteracting its defense system

Kira Smith


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{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.3976104", 
  "language": "eng", 
  "title": "Eradicate Coronavirus by blocking replication, counteracting its defense system", 
  "issued": {
    "date-parts": [
      [
        2020, 
        8, 
        3
      ]
    ]
  }, 
  "abstract": "<p>SIRT1 inhibitors can reduce replication of many viruses with certain similar characteristics to those of Coronaviruses, while p53 protein is another important factor in down-regulation of growth. There are some molecules that inhibit Sirtuin 1 and 2, in addition to activate p53 protein, by means of regulation of the interactions used by Coronaviruses as self-defense mechanism, degradating it. Even mTOR signal will be regulate, as well as autophagy will be inhibited, being this compound like a lysosomotropic agent. By blocking virus growth and continuous replication, associating the already tested Antiviral medicines, Covid-19 could be eradicated.</p>", 
  "author": [
    {
      "family": "Kira Smith"
    }
  ], 
  "note": "Created and uploaded on Academia.edu on March 2020.", 
  "version": "3.0", 
  "type": "article", 
  "id": "3976104"
}
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