Preprint Open Access
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="041" ind1=" " ind2=" "> <subfield code="a">eng</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Coronavirus</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Covid-19</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Covid</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Sars-Cov-2</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Coronavirus replication</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">Eradicate Coronavirus</subfield> </datafield> <datafield tag="653" ind1=" " ind2=" "> <subfield code="a">SIRT1</subfield> </datafield> <controlfield tag="005">20210322085949.0</controlfield> <datafield tag="500" ind1=" " ind2=" "> <subfield code="a">Created and uploaded on Academia.edu on March 2020.</subfield> </datafield> <controlfield tag="001">3971128</controlfield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="s">5598735</subfield> <subfield code="z">md5:7b2db6f69b9000e25e41db759081a985</subfield> <subfield code="u">https://zenodo.org/record/3971128/files/HALT_CORONAVIRUS_REPLICATION_LITE.pdf</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2020-08-03</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="p">openaire</subfield> <subfield code="p">user-covid-19</subfield> <subfield code="p">user-covid19-structure-hub</subfield> <subfield code="p">user-eradicatecovid19</subfield> <subfield code="o">oai:zenodo.org:3971128</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="0">(orcid)0000-0003-4306-4365</subfield> <subfield code="a">Kira Smith</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Coronavirus Treatment: eradicate Coronavirus by blocking replication, counteracting its defense system</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-covid-19</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-covid19-structure-hub</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-eradicatecovid19</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">https://creativecommons.org/licenses/by/4.0/legalcode</subfield> <subfield code="a">Creative Commons Attribution 4.0 International</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="a">cc-by</subfield> <subfield code="2">opendefinition.org</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a"><p>How Treatment works: Coronaviruses reduce p53 protein as defese mechanism, by means an interaction between Sars-unique domain (SUD) and papain-like protease (PLPRO) via E3 ubiquitin ligase RCHY1. P53 is an important factor in downregulation of coronavirus replication, with reduction of Sirtuin 1 SIRT1. Tenovin-1 is a small molecule that inhibits SIRT1 and 2, and activates p53, protecting it against MDM-2 mediated degradation, which involves ubiquitination.</p></subfield> </datafield> <datafield tag="773" ind1=" " ind2=" "> <subfield code="n">doi</subfield> <subfield code="i">isVersionOf</subfield> <subfield code="a">10.5281/zenodo.3971127</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.5281/zenodo.3971128</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">preprint</subfield> </datafield> </record>
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