Kira Smith
2020-08-03
<p>How Treatment works: Coronaviruses reduce p53 protein as defese mechanism, by means an interaction between Sars-unique domain (SUD) and papain-like protease (PLPRO) via E3 ubiquitin ligase RCHY1. P53 is an important factor in downregulation of coronavirus replication, with reduction of Sirtuin 1 SIRT1. Tenovin-1 is a small molecule that inhibits SIRT1 and 2, and activates p53, protecting it against MDM-2 mediated degradation, which involves ubiquitination.</p>
Created and uploaded on Academia.edu on March 2020.
https://doi.org/10.5281/zenodo.3971128
oai:zenodo.org:3971128
eng
Zenodo
https://zenodo.org/communities/covid-19
https://zenodo.org/communities/covid19-structure-hub
https://zenodo.org/communities/eradicatecovid19
https://doi.org/10.5281/zenodo.3971127
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Coronavirus
Covid-19
Covid
Sars-Cov-2
Coronavirus replication
Eradicate Coronavirus
SIRT1
Coronavirus Treatment: eradicate Coronavirus by blocking replication, counteracting its defense system
info:eu-repo/semantics/preprint