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Coronavirus Treatment: eradicate Coronavirus by blocking replication, counteracting its defense system

Kira Smith


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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Kira Smith</dc:creator>
  <dc:date>2020-08-03</dc:date>
  <dc:description>How Treatment works: Coronaviruses reduce p53 protein as defese mechanism, by means an interaction between Sars-unique domain (SUD) and papain-like protease (PLPRO) via E3 ubiquitin ligase RCHY1. P53 is an important factor in downregulation of coronavirus replication, with reduction of Sirtuin 1 SIRT1. Tenovin-1 is a small molecule that inhibits SIRT1 and 2, and activates p53, protecting it against MDM-2 mediated degradation, which involves ubiquitination.</dc:description>
  <dc:description>Created and uploaded on Academia.edu on March 2020.</dc:description>
  <dc:identifier>https://zenodo.org/record/3971128</dc:identifier>
  <dc:identifier>10.5281/zenodo.3971128</dc:identifier>
  <dc:identifier>oai:zenodo.org:3971128</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>doi:10.5281/zenodo.3971127</dc:relation>
  <dc:relation>url:https://zenodo.org/communities/covid-19</dc:relation>
  <dc:relation>url:https://zenodo.org/communities/covid19-structure-hub</dc:relation>
  <dc:relation>url:https://zenodo.org/communities/eradicatecovid19</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>https://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
  <dc:subject>Coronavirus</dc:subject>
  <dc:subject>Covid-19</dc:subject>
  <dc:subject>Covid</dc:subject>
  <dc:subject>Sars-Cov-2</dc:subject>
  <dc:subject>Coronavirus replication</dc:subject>
  <dc:subject>Eradicate Coronavirus</dc:subject>
  <dc:subject>SIRT1</dc:subject>
  <dc:title>Coronavirus Treatment: eradicate Coronavirus by blocking replication, counteracting its defense system</dc:title>
  <dc:type>info:eu-repo/semantics/preprint</dc:type>
  <dc:type>publication-preprint</dc:type>
</oai_dc:dc>
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