August 3, 2020 Preprint Open Access

Kira Smith

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{
  "inLanguage": {
    "alternateName": "eng", 
    "@type": "Language", 
    "name": "English"
  }, 
  "description": "<p>How Treatment works: Coronaviruses reduce p53 protein as defese mechanism, by means an interaction between Sars-unique domain (SUD) and papain-like protease (PLPRO) via E3 ubiquitin ligase RCHY1. P53 is an important factor in downregulation of coronavirus replication, with reduction of Sirtuin 1 SIRT1. Tenovin-1 is a small molecule that inhibits SIRT1 and 2, and activates p53, protecting it against MDM-2 mediated degradation, which involves ubiquitination.</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "@id": "https://orcid.org/0000-0003-4306-4365", 
      "@type": "Person", 
      "name": "Kira Smith"
    }
  ], 
  "headline": "Coronavirus Treatment: eradicate Coronavirus by blocking replication, counteracting its defense system", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2020-08-03", 
  "url": "https://zenodo.org/record/3971128", 
  "keywords": [
    "Coronavirus", 
    "Covid-19", 
    "Covid", 
    "Sars-Cov-2", 
    "Coronavirus replication", 
    "Eradicate Coronavirus", 
    "SIRT1"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.3971128", 
  "@id": "https://doi.org/10.5281/zenodo.3971128", 
  "@type": "ScholarlyArticle", 
  "name": "Coronavirus Treatment: eradicate Coronavirus by blocking replication, counteracting its defense system"
}