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Statistical study of the relationship between hyperuricemia, dyslipidemia and type 2 diabetes in rural population of Tizi-Ouzou, Algeria

Lefsih, Khalef; Dahmani, Dalila; Cherrad, Rabah; Lalaoui, Souad; Amrara, Sarah


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{
  "description": "<p><strong>Aim : </strong>The main objective of our work was to assess the relationship between type 2 diabetes, hyperuricemia and dyslipidemia in the population of Tizi-Ouzou. By evaluating the relationship between hyperuricemia and some blood lipid parameters, we thus establish, in type 2 diabetes, the correlation between uremia and these lipid parameters. <strong>Subjects and methods</strong>: &nbsp;The survey was carried out by means of an individual questionnaire. We excluded from our study pregnant women, patients with cancer, patients with end-stage renal disease and subjects who did not respond to the questionnaire. <strong>Results</strong>: &nbsp;Serum uric acid level increased with age (p = 0.025). Hyperuricemia was associated with heart disease (p = 0.0007). All patients with gout presented an elevated serum uric acid (p = 0.000001). Dyslipidemia was more common in patients with elevated serum uric acid levels (p = 0.0008). Triglyceridemia was significantly associated with hyperuricemia (p = 0.025). The relationship between type 2 diabetes and glomerular filtration rate&nbsp; was not significant, while the latter was decreased in patients with elevated serum uric acid levels (p = 0.0001). In, stratified analysis, age was effect modifier, the age-dependent results make us understand that resistance to insulin constitutes a significant factor of hyperuricemia. <strong>Conclusion:</strong> The association between hyperuricemia and dyslipidemia in type 2 diabetes emphasizes that insulin resistance acts on both lipid parameters and uricemia. A diet correcting dyslipidemia may also correct the uricemia.</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Biochemistry and microbiology department, FSBSA, University of Tizi-Ouzou, Algeria", 
      "@id": "https://orcid.org/0000-0002-7661-2121", 
      "@type": "Person", 
      "name": "Lefsih, Khalef"
    }, 
    {
      "affiliation": "Biochemistry laboratory, CHU Tizi-Ouzou, Algeria", 
      "@type": "Person", 
      "name": "Dahmani, Dalila"
    }, 
    {
      "affiliation": "Epidemiology and preventive medicine department, CHU Tizi-Ouzou, Algeria", 
      "@type": "Person", 
      "name": "Cherrad, Rabah"
    }, 
    {
      "affiliation": "Biochemistry and microbiology department, FSBSA, University of Tizi-Ouzou, Algeria", 
      "@type": "Person", 
      "name": "Lalaoui, Souad"
    }, 
    {
      "affiliation": "Biochemistry and microbiology department, FSBSA, University of Tizi-Ouzou, Algeria", 
      "@type": "Person", 
      "name": "Amrara, Sarah"
    }
  ], 
  "headline": "Statistical study of the relationship between hyperuricemia, dyslipidemia and type 2 diabetes in rural population of Tizi-Ouzou, Algeria", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2020-08-08", 
  "url": "https://zenodo.org/record/3970038", 
  "keywords": [
    "hyperuricemia", 
    "diabetes type 2", 
    "dyslipidemia", 
    "lipoproteins"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.3970038", 
  "@id": "https://doi.org/10.5281/zenodo.3970038", 
  "@type": "ScholarlyArticle", 
  "name": "Statistical study of the relationship between hyperuricemia, dyslipidemia and type 2 diabetes in rural population of Tizi-Ouzou, Algeria"
}
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