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Statistical study of the relationship between hyperuricemia, dyslipidemia and type 2 diabetes in rural population of Tizi-Ouzou, Algeria

Lefsih, Khalef; Dahmani, Dalila; Cherrad, Rabah; Lalaoui, Souad; Amrara, Sarah


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  <identifier identifierType="DOI">10.5281/zenodo.3970038</identifier>
  <creators>
    <creator>
      <creatorName>Lefsih, Khalef</creatorName>
      <givenName>Khalef</givenName>
      <familyName>Lefsih</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0002-7661-2121</nameIdentifier>
      <affiliation>Biochemistry and microbiology department, FSBSA, University of Tizi-Ouzou, Algeria</affiliation>
    </creator>
    <creator>
      <creatorName>Dahmani, Dalila</creatorName>
      <givenName>Dalila</givenName>
      <familyName>Dahmani</familyName>
      <affiliation>Biochemistry laboratory, CHU Tizi-Ouzou, Algeria</affiliation>
    </creator>
    <creator>
      <creatorName>Cherrad, Rabah</creatorName>
      <givenName>Rabah</givenName>
      <familyName>Cherrad</familyName>
      <affiliation>Epidemiology and preventive medicine department, CHU Tizi-Ouzou, Algeria</affiliation>
    </creator>
    <creator>
      <creatorName>Lalaoui, Souad</creatorName>
      <givenName>Souad</givenName>
      <familyName>Lalaoui</familyName>
      <affiliation>Biochemistry and microbiology department, FSBSA, University of Tizi-Ouzou, Algeria</affiliation>
    </creator>
    <creator>
      <creatorName>Amrara, Sarah</creatorName>
      <givenName>Sarah</givenName>
      <familyName>Amrara</familyName>
      <affiliation>Biochemistry and microbiology department, FSBSA, University of Tizi-Ouzou, Algeria</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Statistical study of the relationship between hyperuricemia, dyslipidemia and type 2 diabetes in rural population of Tizi-Ouzou, Algeria</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2020</publicationYear>
  <subjects>
    <subject>hyperuricemia</subject>
    <subject>diabetes type 2</subject>
    <subject>dyslipidemia</subject>
    <subject>lipoproteins</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2020-08-08</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/3970038</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.5281/zenodo.3970037</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;&lt;strong&gt;Aim : &lt;/strong&gt;The main objective of our work was to assess the relationship between type 2 diabetes, hyperuricemia and dyslipidemia in the population of Tizi-Ouzou. By evaluating the relationship between hyperuricemia and some blood lipid parameters, we thus establish, in type 2 diabetes, the correlation between uremia and these lipid parameters. &lt;strong&gt;Subjects and methods&lt;/strong&gt;: &amp;nbsp;The survey was carried out by means of an individual questionnaire. We excluded from our study pregnant women, patients with cancer, patients with end-stage renal disease and subjects who did not respond to the questionnaire. &lt;strong&gt;Results&lt;/strong&gt;: &amp;nbsp;Serum uric acid level increased with age (p = 0.025). Hyperuricemia was associated with heart disease (p = 0.0007). All patients with gout presented an elevated serum uric acid (p = 0.000001). Dyslipidemia was more common in patients with elevated serum uric acid levels (p = 0.0008). Triglyceridemia was significantly associated with hyperuricemia (p = 0.025). The relationship between type 2 diabetes and glomerular filtration rate&amp;nbsp; was not significant, while the latter was decreased in patients with elevated serum uric acid levels (p = 0.0001). In, stratified analysis, age was effect modifier, the age-dependent results make us understand that resistance to insulin constitutes a significant factor of hyperuricemia. &lt;strong&gt;Conclusion:&lt;/strong&gt; The association between hyperuricemia and dyslipidemia in type 2 diabetes emphasizes that insulin resistance acts on both lipid parameters and uricemia. A diet correcting dyslipidemia may also correct the uricemia.&lt;/p&gt;</description>
  </descriptions>
</resource>
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